Results 61 to 70 of about 492,866 (322)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

miRNAs link metabolic reprogramming to oncogenesis [PDF]

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M, Iliopoulos, D, Polytarchou, C   +2 more
core   +1 more source

Selective and Precise Editing of Digital Polymers Through Parallel or Series Toehold‐Mediated Strand Displacement

Advanced Functional Materials, EarlyView.
A sequence‐encoded supramolecular construct containing two accessible toeholds is developed herein for enabling multiple editing operations. By introducing specific input strands, it is possible to selectively erase or rewrite digital content through parallel or series toehold‐mediated strand displacement (PTMSD or STMSD).
Jakub Ossowski, Cyril Antheaume, Jean‐François Lutz, Maria Nerantzaki   +3 more
wiley   +1 more source

Glutamine and glutamate as vital metabolites

Brazilian Journal of Medical and Biological Research, 2003
Glucose is widely accepted as the primary nutrient for the maintenance and promotion of cell function. This metabolite leads to production of ATP, NADPH and precursors for the synthesis of macromolecules such as nucleic acids and phospholipids.
Newsholme P., Lima M.M.R., Procopio J., Pithon-Curi T.C., Doi S.Q., Bazotte R.B., Curi R.   +6 more
doaj  

Promotion of embryonic cortico-cerebral neuronogenesis by miR-124

Neural Development, 2009
Background Glutamatergic neurons of the murine cerebral cortex are generated within periventricular proliferative layers of the embryonic pallium, directly from apical precursors or indirectly via their basal progenies.
Mallamaci Antonello, Maiorano Nicola
doaj   +1 more source

Molecular analysis of the early interaction between the grapevine flower and Botrytis cinerea reveals that prompt activation of specific host pathways leads to fungus quiescence [PDF]

, 2017
Grape quality and yield can be impaired by bunch rot, caused by the necrotrophic fungus Botrytis cinerea. Infection often occurs at flowering, and the pathogen stays quiescent until fruit maturity.
Agudelo-Romero, Alkan, Amselem, Asselbergh, Bhuiyan, Birkenbihl, Blanco-Ulate, Boller, Bradley, Brutus, Caffall, Cantu, Choquer, Coertze, Conesa, Costa, Dadakova, Dalmais, De Cremer, Deytieux-Belleau, Du, Eichorn, Elmer, Espino, Favaron, Giannakis, Gilbert, Godfrey, Goetz, Grimplet, Guetsky, Hammerbacher, Hellemans, Höll, Jaillon, Jarvis, Jarvis, Jeandet, Jersch, Kan, Kan, Kan, Keller, Kelloniemi, Kemmerling, Kretschmer, Langcake, Law, Lebel, Lee, Leroch, Leroch, Liao, Liao, Lijavetzky, Liu, Malacarne, Marrs, Martin, McClellan, McNicol, Merz, Mlikota-Gabler, Mohnen, Monteiro, Moretto, Mullins, Nagpala, Nair, Naoumkina, Noda, Padgett, Pezet, Pezet, Prusky, Prusky, Prusky, Puhl, Rieu, Rolke, Rossi, Ruijter, Schouten, Schouten, Schumacher, Schumacher, Shaw, Smith, Smyth, Thimm, Vandesompele, Vannozzi, Velasco, Volodarsky, Vrhovsek, Waite, Weng, Wiermer, Williamson, Williamson, Zhang, Zhang, Zhao   +102 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

The Origin and Evolution of Viruses as Molecular Organisms [PDF]

, 2009
Viruses are the most abundant life forms and the repertoire of viral genes is greater than that of cellular genes. It is also evident that viruses have played a major role in driving cellular evolution, and yet, viruses are not part of mainstream biology,
Claudiu I. Bandea
core   +2 more sources

Chemoselective Sequential Polymerization: An Approach Toward Mixed Plastic Waste Recycling

Advanced Functional Materials, EarlyView.
Inspired by biological protein metabolism, this study demonstrates the closed‐loop recycling of mixed synthetic polymers via ring‐closing depolymerization followed by a chemoselective sequential polymerizations process. The approach recovers pure polymers from mixed feedstocks, even in multilayer formats, highlighting a promising strategy to overcome a
Gadi Slor, Youwei Ma, Hyunwoo Park, Tae‐Lim Choi, Damien Guironnet, Francesco Stellacci   +5 more
wiley   +1 more source

Prebiotic Soup Components Trapped in Montmorillonite Nanoclay Form New Molecules: Car-Parrinello Ab Initio Simulations

Life, 2019
The catalytic effects of complex minerals or meteorites are often mentioned as important factors for the origins of life. To assess the possible role of nanoconfinement within a catalyst consisting of montmorillonite (MMT) and the impact of local ...
Juan Francisco Carrascoza Mayén, Jakub Rydzewski, Natalia Szostak, Jacek Blazewicz, Wieslaw Nowak   +4 more
doaj   +1 more source