Results 61 to 70 of about 414,760 (197)

Prebiotic Soup Components Trapped in Montmorillonite Nanoclay Form New Molecules: Car-Parrinello Ab Initio Simulations

Life, 2019
The catalytic effects of complex minerals or meteorites are often mentioned as important factors for the origins of life. To assess the possible role of nanoconfinement within a catalyst consisting of montmorillonite (MMT) and the impact of local ...
Juan Francisco Carrascoza Mayén, Jakub Rydzewski, Natalia Szostak, Jacek Blazewicz, Wieslaw Nowak   +4 more
doaj   +1 more source

The Alanine World Model for the Development of the Amino Acid Repertoire in Protein Biosynthesis [PDF]

, 2019
A central question in the evolution of the modern translation machinery is the origin and chemical ethology of the amino acids prescribed by the genetic code.
Budisa, Nediljko, Kubyshkin, Vladimir
core   +1 more source

Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells

Frontiers in Pharmacology, 2018
Antifolates are a class of drugs effective for treating malignant pleural mesothelioma (MPM). The majority of antifolates inhibit enzymes involved in purine and pyrimidine synthesis such as dihydrofolate reductase (DHFR), thymidylate synthase (TYMS), and
Yuzo Sato, Yuzo Sato, Yuzo Sato, Yuzo Sato, Shiori Matsuda, Shiori Matsuda, Shiori Matsuda, Ami Maruyama, Ami Maruyama, Joji Nakayama, Joji Nakayama, Joji Nakayama, Tomoyuki Miyashita, Tomoyuki Miyashita, Tomoyuki Miyashita, Hibiki Udagawa, Shigeki Umemura, Kazuyoshi Yanagihara, Atsushi Ochiai, Masaru Tomita, Masaru Tomita, Tomoyoshi Soga, Tomoyoshi Soga, Katsuya Tsuchihara, Hideki Makinoshima, Hideki Makinoshima   +25 more
doaj   +1 more source

Partial (13)C isotopic enrichment of nucleoside monophosphates: useful reporters for NMR structural studies [PDF]

, 2005
Analysis of the (13)C isotopic labeling patterns of nucleoside monophosphates (NMPs) extracted from Escherichia coli grown in a mixture of C-1 and C-2 glucose is presented. By comparing our results to previous observations on amino acids grown in similar
Kishore, Anita I., Mayer, Michael R., Prestegard, James H.   +2 more
core   +2 more sources

Co-infection of Sweet Orange with Severe and Mild Strains of Citrus tristeza virus Is Overwhelmingly Dominated by the Severe Strain on Both the Transcriptional and Biological Levels

Frontiers in Plant Science, 2017
Citrus tristeza is one of the most destructive citrus diseases and is caused by the phloem-restricted Closterovirus, Citrus tristeza virus. Mild strain CTV-B2 does not cause obvious symptoms on indicators whereas severe strain CTV-B6 causes symptoms ...
Shimin Fu, Shimin Fu, Jonathan Shao, Changyong Zhou, John S. Hartung   +4 more
doaj   +1 more source

Studies on the relation between heme and nucleic acid syntheses in erythroid cell. 3. Nucleolus of erythroblast, changes in relation with cell specialization [PDF]

, 1969
The disappearance of nucleolus has been traced in the rat erythroid cells in relation with the cell specialization under varying conditions, i. e. in anemia with or without treatment by bromouracil and aminopterin.
Shigehisa, Morio
core   +1 more source

Determination of nucleosides in Cordyceps sinensis and Ganoderma lucidum by high performance liquid chromatography method

Journal of Pharmacy and Bioallied Sciences, 2015
Background: Nucleosides are supportive in the regulation and modulation of various physiological processes in body, they acts as precursors in nucleic acid synthesis, enhance immune response, help in absorption of iron and influence the metabolism of ...
Masood Shah Khan, Rabea Parveen, Kshipra Mishra, Rajkumar Tulsawani, Sayeed Ahmad   +4 more
doaj   +1 more source

Cell-Free Synthesis of the Mitochondrial ADP/ATP Carrier Protein of Neurospora crassa [PDF]

, 1979
ADP/ATP carrier protein was synthesized in heterologous cell-free systems programmed with Neurospora poly(A)-containing RNA and homologous cell-free systems from Neurospora.
Allen E. H., Aviv H., Blomback B., Cassio D., Dubnoff J. S., Fraser T. H., Hackenberg H., Hallermayer G., Harmey M. A., Inouye S., Klingenberg M., Korb H., Laemmli U. K., Leaver C. J., Lodish H. F., Maccechini M.-L., Marahiel M. A., Michel R., Palmiter R. D., Pelham H. R. B., Roberts B. E., Scheele G., Sebald W., Stewart J. W., Vignais P. V., Zitomer R. S.   +25 more
core   +1 more source

Severe anaemia is not associated with HIV-1 env gene characteristics in Malawian children

BMC Infectious Diseases, 2008
Background Anaemia is the most common haematological complication of HIV and associated with a high morbidity and a poor prognosis. The pathogenesis of HIV-associated anaemia is poorly understood and may include a direct effect of HIV on erythropoiesis ...
Kachala David, Zorgdrager Fokla, van der Kuyl Antoinette C, Rotteveel Hellen P, Calis Job CJ, van Hensbroek Michaël, Cornelissen Marion   +6 more
doaj   +1 more source

The Origin and Evolution of Viruses as Molecular Organisms [PDF]

, 2009
Viruses are the most abundant life forms and the repertoire of viral genes is greater than that of cellular genes. It is also evident that viruses have played a major role in driving cellular evolution, and yet, viruses are not part of mainstream biology,
Claudiu I. Bandea
core   +2 more sources