Results 81 to 90 of about 437,756 (347)

Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells

Frontiers in Pharmacology, 2018
Antifolates are a class of drugs effective for treating malignant pleural mesothelioma (MPM). The majority of antifolates inhibit enzymes involved in purine and pyrimidine synthesis such as dihydrofolate reductase (DHFR), thymidylate synthase (TYMS), and
Yuzo Sato, Yuzo Sato, Yuzo Sato, Yuzo Sato, Shiori Matsuda, Shiori Matsuda, Shiori Matsuda, Ami Maruyama, Ami Maruyama, Joji Nakayama, Joji Nakayama, Joji Nakayama, Tomoyuki Miyashita, Tomoyuki Miyashita, Tomoyuki Miyashita, Hibiki Udagawa, Shigeki Umemura, Kazuyoshi Yanagihara, Atsushi Ochiai, Masaru Tomita, Masaru Tomita, Tomoyoshi Soga, Tomoyoshi Soga, Katsuya Tsuchihara, Hideki Makinoshima, Hideki Makinoshima   +25 more
doaj   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Co-infection of Sweet Orange with Severe and Mild Strains of Citrus tristeza virus Is Overwhelmingly Dominated by the Severe Strain on Both the Transcriptional and Biological Levels

Frontiers in Plant Science, 2017
Citrus tristeza is one of the most destructive citrus diseases and is caused by the phloem-restricted Closterovirus, Citrus tristeza virus. Mild strain CTV-B2 does not cause obvious symptoms on indicators whereas severe strain CTV-B6 causes symptoms ...
Shimin Fu, Shimin Fu, Jonathan Shao, Changyong Zhou, John S. Hartung   +4 more
doaj   +1 more source

Bio‐Inspired Molecular Events in Poly(Ionic Liquids)

Advanced Functional Materials, EarlyView.
Originating from dipolar and polar inter‐ and intra‐chain interactions of the building blocks, the topologies and morphologies of poly(ionic liquids) (PIL) govern their nano‐ and micro‐processibility. Modulating the interactions of cation‐anion pairs with aliphatic dipolar components enables the tunability of properties, facilitated by “bottom‐up ...
Jiahui Liu, Marek W. Urban
wiley   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Novel Fmoc-Polyamino Acids for Solid-Phase Synthesis of Defined Polyamidoamines [PDF]

, 2011
A versatile solid-phase approach to sequence-defined polyamidoamines was developed. Four different Fmoc-polyamino acid building blocks were synthesized by selective protection of symmetrical oligoethylenimine precursors followed by introduction of a ...
Badgujar, Naresh, Schaffert, David, Wagner, Ernst   +2 more
core   +1 more source

Metallofullerenol Sc3N@C80(OH)18: A New Generation Radioprotector Protecting Human Erythrocytes Against Multiple Biochemical Damage Modes Upon Gamma Irradiation, Identifying It as a Scavenger of Short‐ and Long‐Lived Radicals

Advanced Healthcare Materials, EarlyView.
Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski, Maciej Studzian, Szymon Lekki‐Porebski, Anna Konarska, Marian Wolszczak, Grzegorz Litwinienko, Lukasz Pulaski   +6 more
wiley   +1 more source

Alignment of the amino terminal amino acid sequence of human cytochrome c oxidase subunits I and II with the sequence of their putative mRNAs [PDF]

, 1981
Thirteen of the first fifteen amino acids from the NH2-terminus of the primary sequence of human cytochrome c oxidase subunit I and eleven of the first twelve amino acids of subunit II have been identified by microsequencing procedures.
Attardi, Giuseppe, Chomyn, Anne, Hunkapiller, Michael W.   +2 more
core   +2 more sources

Customizable Fabrication of 2D and Conformal Multielectrode Arrays for 3D Printed Organotypic Bioelectronic Interfaces

Advanced Healthcare Materials, EarlyView.
Aerosol jet printing enables rapid, customizable fabrication of flexible, fully gold multi‐electrode arrays (MEAs) for organotypic bioelectronic interfaces. The printed MEAs exhibit stable electrochemical performance, cytocompatibility, and functionality in recording and stimulation, including integration with 3D‐printed constructs.
Ernest Cheah, Xinchao Gao, Wei Qi Jaw, Guo Liang Goh, Jia Min Lee, Chongquan Huang, Sing Yian Chew, Wai Yee Yeong   +7 more
wiley   +1 more source

The processing peptidase of yeast mitochondria [PDF]

, 1988
Two proteins co-operate in the proteolytic cleavage of mitochondrial precursor proteins: the mitochondrial processing peptidase (MPP) and the processing enhancing protein (PEP).
Cheng, Ming Yuan, Hartl, Franz-Ulrich, Horwich, Arthur, Neupert, Walter, Ostermann, Joachim, Pollock, Robert A.   +5 more
core