MeltR software provides facile determination of nucleic acid thermodynamics [PDF]
Biophysical Reports, 2023 Thermodenaturation (melting) curves of macromolecules are used to determine folding thermodynamic parameters. Notably, this insight into RNA and DNA stability underlies nearest neighbor theory and diverse structure prediction tools.
Jacob P. Sieg +3 more
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Nucleic Acid Thermodynamics Derived from Mechanical Unzipping Experiments [PDF]
Life, 2022 Force-spectroscopy techniques have led to significant progress in studying the physicochemical properties of biomolecules that are not accessible in bulk assays. The application of piconewton forces with laser optical tweezers to single nucleic acids has
Paolo Rissone, Felix Ritort
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Novel isoguanine derivative of unlocked nucleic acid-Investigations of thermodynamics and biological potential of modified thrombin binding aptamer. [PDF]
PLoS ONE, 2018 Thrombin binding aptamer (TBA), is a short DNA 15-mer that forms G-quadruplex structure and possesses anticoagulant properties. Some chemical modifications, including unlocked nucleic acids (UNA), 2'-deoxy-isoguanosine and 2'-deoxy-4-thiouridine were ...
Weronika Kotkowiak +2 more
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Native characterization of nucleic acid motif thermodynamics via non-covalent catalysis [PDF]
Nature Communications, 2016 DNA hybridisation thermodynamics parameters underlie rational design of oligonucleotides for diagnostics and nanotechnology. Here, the authors present an accurate method to measure the free energy of a given DNA structure at specific temperature and ...
Chunyan Wang, Jin H. Bae, David Yu Zhang
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Optical melting measurements of nucleic acid thermodynamics. [PDF]
Methods Enzymol, 2009 Schroeder SJ, Turner DH.
europepmc +3 more sources
Theoretical Modeling of the Redox Thermodynamics of Nucleic Acid Building Blocks in the Condensed Phase. [PDF]
J Phys Chem BOlivieri A, Nardi AN, D'Abramo M.
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Monovalent metal ion binding promotes the first transesterification reaction in the spliceosome
Nature Communications, 2023 Cleavage and formation of phosphodiester bonds in nucleic acids is accomplished by large cellular machineries composed of both protein and RNA. Long thought to rely on a two-metal-ion mechanism for catalysis, structure comparisons revealed many contain ...
Jana Aupič +4 more
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Thermodynamic framework to assess low abundance DNA mutation detection by hybridization. [PDF]
PLoS ONE, 2017 The knowledge of genomic DNA variations in patient samples has a high and increasing value for human diagnostics in its broadest sense. Although many methods and sensors to detect or quantify these variations are available or under development, the ...
Hanny Willems +7 more
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Theory on the mechanism of DNA renaturation: Stochastic nucleation and zipping [PDF]
, 2015 Renaturation of complementary single strands of DNA is one of the important processes that requires better understanding in the view of molecular biology and biological physics.
Murugan, Rajamanickam +1 more
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On binding mechanism exploration of organic amphoteric dye Rhodamine B with natural polymeric DNA
Discover Materials, 2023 Nucleic acids, like DNA and RNA, are molecules that are present in any life form. Their most notable function is to encode biological information.
Senchumbeni Yanthan +1 more
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