Results 1 to 10 of about 10,704 (260)
Nucleic Acid Thermodynamics Derived from Mechanical Unzipping Experiments [PDF]
Life, 2022 Force-spectroscopy techniques have led to significant progress in studying the physicochemical properties of biomolecules that are not accessible in bulk assays. The application of piconewton forces with laser optical tweezers to single nucleic acids has
Paolo Rissone, Felix Ritort
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MeltR software provides facile determination of nucleic acid thermodynamics [PDF]
Biophysical Reports, 2023 Thermodenaturation (melting) curves of macromolecules are used to determine folding thermodynamic parameters. Notably, this insight into RNA and DNA stability underlies nearest neighbor theory and diverse structure prediction tools.
Jacob P. Sieg +3 more
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Computer Methods and Programs in Biomedicine, 2013 Proper design of nucleic acid sequences is crucial for many applications. We have previously established a thermodynamics-based quantitative model to help design aptamer-based nucleic acid probes by predicting equilibrium concentrations of all ...
Zou, Jiaqi, Li, Na
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Optical melting measurements of nucleic acid thermodynamics. [PDF]
Methods Enzymol, 2009 Optical melting experiments provide measurements of thermodynamic parameters for nucleic acids. These thermodynamic parameters are widely used in RNA structure prediction programs and DNA primer design software. This review briefly summarizes the theory and underlying assumptions of the method and provides practical details for instrument calibration ...
Schroeder SJ, Turner DH.
europepmc +4 more sources
Thermodynamics of Nucleic Acid “Shape Readout” by an Aminosugar [PDF]
Biochemistry, 2011 Recognition of nucleic acids is important for our understanding of nucleic acid structure as well as for our understanding of nucleic acid-protein interactions. In addition to the direct readout mechanisms of nucleic acids such as H-bonding, shape recognition of nucleic acids is being increasingly recognized as playing an equally important role in DNA ...
Nihar Ranjan, , Dev P Arya
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Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides [PDF]
Nucleic Acids Research, 2010 Thermodynamics provides insights into the influ-ence of modified nucleotide residues on stability of nucleic acids and is crucial for designing duplexes with given properties.
Jesper Wengel +3 more
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Nucleic acid-lipid membrane interactions studied by DSC
Journal of Pharmacy and Bioallied Sciences, 2011 The interactions of nucleic acids with lipid membranes are of great importance for biological mechanisms as well as for biotechnological applications in gene delivery and drug carriers. The optimization of liposomal vectors for clinical use is absolutely
Sarantis Giatrellis, George Nounesis
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Journal of Physical Chemistry B, 2009 Thermodynamic studies of nucleic acids serve not only to widen our understanding on the nature and strength of forces that stabilize nucleic acids in a myriad of structural states they assume but also to facilitate the development of databases that could
Vaijayanti A Kumar, Souvik Maiti
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Nucleic Acid Binding Thermodynamics and Functions of DNA Polymerases
, 2013 This study examines several different linkages between the nucleic acid binding thermodynamics and the functions of three different DNA polymerases. The focuses are correlation of the DNA binding thermodynamics and the functional behavior of Klenow and ...
Brown, Hiromi Shimasaki
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Thermodynamic analysis of Zα domain-nucleic acid interactions [PDF]
Biochemical Journal, 2022 Abstract DNA/RNA molecules adopting the left-handed conformation (Z-form) have been attributed with immunogenic properties. However, their biological role and importance has been a topic of debate for many years. The discovery of Z-DNA/RNA binding domains (Zα domains) in varied proteins that are involved in the innate
Bharath Srinivasan +2 more
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