Results 91 to 100 of about 192,096 (245)

Peptide Nucleic Acids Containing Cationic/Amino-Alkyl Modified Bases Promote Enhanced Hybridization Kinetics and Thermodynamics with Single-Strand DNA

, 2023
Frank Podlaski, Stephen Cornwell, Kenny K. Wong, Brian A. McKittrick, Jae‐Hun Kim, Daram Jung, Yeasel Jeon, Kwang‐Bok Jung, Peter Tolias, William T. Windsor   +9 more
openalex   +1 more source

Deciphering the Toxicity of Metal Tungstates and Molybdates: Effects on L929 Cell Metabolic Activity, Oxidative Stress, and Genotoxicity

Journal of Applied Toxicology, EarlyView.
ABSTRACT The increasing development and application of metal‐based materials in biomedical and environmental fields raise important concerns regarding their potential cytotoxic and genotoxic effects. Metal tungstates (MxWO4) and molybdates (MxMoO4) offer promising functional properties in health and environmental solutions but require safety validation
Marcelo Assis, Amanda de Souza, Karolyne dos Santos Jorge Sousa, Diana Gabriela Nina Nina, Mirian Bonfacio, Renata Neves Granito, Ana Claudia Muniz Rennó   +6 more
wiley   +1 more source

Mechanically Tunable DNA Hydrogels as Prospective Biosensing Modules

Macromolecular Rapid Communications, EarlyView.
Sequence‐programmable and thermally responsive DNA hydrogels enable highly sensitive mechanical biosensing through the exchange of linker strands using a toehold strand displacement mechanism. This new type of mechanical biosensor has in‐built sequence‐specificity and dose‐sensitivity, obviating the need for elaborate DNA sequencing and enabling rapid ...
Asya E. Can, Abdul W. U. Ali, Claude Oelschlaeger, Norbert Willenbacher, Iliya D. Stoev   +4 more
wiley   +1 more source

Thermodynamics of the interactions ofm-AMSA ando-AMSA with nucleic acids: influence of ionic strength and DNA base composition [PDF]

, 1989
Randy M. Wadkins, David E. Graves
openalex   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Polyethylene Glycol‐Functionalized Graphene Oxide Nanocomposites: Advances in Biomedical Applications

Nano Select, EarlyView.
Polyethylene glycol‐functionalized graphene oxide (PEG‐GO) nanocomposites revolutionize nanomedicine with their high surface area and tunable properties. This review explores their synthesis, characterization, and applications in drug delivery, gene therapy, biosensing, and photothermal therapy.
Oluwasegun Chijioke Adekoya, Gbolahan Joseph Adekoya, Williams Kehinde Kupolati, Yskandar Hamam, Rotimi Emmanuel Sadiku   +4 more
wiley   +1 more source

Voltammmetric Assessment and Examination of the Interactions between Levetiracetam and DNA: Experimental Research, Molecular Docking, and Modeling Studies

ChemistryOpen, EarlyView.
This research introduces, for the first time, a novel, efficient, cost‐effective, and highly sensitive approach for the quantification of levetiracetam (LEV) through a differential pulse voltammetry technique based on its interaction with DNA. The method capitalizes on the changes observed in the oxidation current peak of the deoxyguanosine base, which
Abdullah Al Faysal, Pelin Şenel, Taner Erdoğan, Ayşegül Gölcü   +3 more
wiley   +1 more source

Synergies in Self‐Assembly—From Supramolecular Polymers to Defined Hierarchical Superstructures

Journal of Polymer Science, EarlyView.
Shaping supramolecular polymers built from molecular building blocks into superstructures with defined dimensions. Synergies within supramolecular architectures such as chirality or an additional second orthogonal driving force that does not interfere with the central supramolecular motif facilitate the confinement of the growth of these ...
Klaus Kreger, Florian Behrendt, Johannes C. Brendel   +2 more
wiley   +1 more source

Cyclodextrin‐Based Pseudocopolymers and Their Biomedical Applications for Drug and Gene Delivery

Small, EarlyView.
Host–guest interactions between cyclodextrin (CD) and compatible guest molecules enable the formation of diverse architectures, such as multiblock and linear–star copolymers as well as advanced systems like redox‐responsive nanoparticles. This structural versatility facilitates precise system design, conferring multifunctionality for controlled drug ...
Wilson Wee Mia Soh, Jun Li
wiley   +1 more source

Functional and Structural Analyses of Diverse G‐Quadruplex and Non‐G‐Quadruplex Structures Formed by Guanine‐Rich Nucleic Acids: A Study on the Insulin Aptamer

Small, EarlyView.
IGA3, a guanine‐rich insulin aptamer, adopts different structures depending on environmental conditions. Under low cation concentrations, IGA3 forms a non‐G‐quadruplex structure that interacts with insulin. This finding highlights that guanine‐rich nucleic acids, in structures other than G‐quadruplex, can also bind to proteins, revealing valuable ...
Naoya Iwano, Taiji Oyama, Mizuki Tomizawa, Shintaro Inaba, Ryuma Mori, Yasumoto Nakazawa, Koji Sode, Kaori Tsukakoshi, Takayuki Nakano, Kazunori Ikebukuro   +9 more
wiley   +1 more source