Results 91 to 100 of about 191,094 (249)

Mechanically Tunable DNA Hydrogels as Prospective Biosensing Modules

Macromolecular Rapid Communications, EarlyView.
Sequence‐programmable and thermally responsive DNA hydrogels enable highly sensitive mechanical biosensing through the exchange of linker strands using a toehold strand displacement mechanism. This new type of mechanical biosensor has in‐built sequence‐specificity and dose‐sensitivity, obviating the need for elaborate DNA sequencing and enabling rapid ...
Asya E. Can, Abdul W. U. Ali, Claude Oelschlaeger, Norbert Willenbacher, Iliya D. Stoev   +4 more
wiley   +1 more source

Peptide Nucleic Acids Containing Cationic/Amino-Alkyl Modified Bases Promote Enhanced Hybridization Kinetics and Thermodynamics with Single-Strand DNA

, 2023
Frank Podlaski, Stephen Cornwell, Kenny K. Wong, Brian A. McKittrick, Jae‐Hun Kim, Daram Jung, Yeasel Jeon, Kwang‐Bok Jung, Peter Tolias, William T. Windsor   +9 more
openalex   +1 more source

Progress in Aptamer Research and Future Applications

ChemistryOpen, EarlyView.
This paper mainly describes the screening method of aptamer, the screening difficulties and improvement methods of small molecule aptamer, and the application and treatment of aptamer. It explores the latest progress and application of aptamers, and summarises them, thus indicating some problems that still exist in this field.
Song Liu, Xiaolu Li, Huyang Gao, Jing Chen, Hongfeng Jiang   +4 more
wiley   +1 more source

NIR‐Induced Photoswitching Hybrid DNA Nanoconstruct‐Based Drug Delivery System for Spatiotemporal Control of Stem Cell Fate

Small, EarlyView.
NIR‐mediated photo‐switching drug delivery system for the remote‐control differentiation of NSCs. Left: NIR‐mediated curcumin release is induced by NIR‐to‐UV photon upconversion in a photo‐controllable manner. Curcumin is bound in the minor groove of the synthesized DNA construct containing AAP photo‐switchers. Right: The rational design of several AAP
Thanapat Pongkulapa, Ji Hye Yum, Callan D. McLoughlin, Brandon Conklin, Tomotaka Kumagai, Li Ling Goldston, Hiroshi Sugiyama, Soyoung Park, Ki‐Bum Lee   +8 more
wiley   +1 more source

Thermodynamics of the interactions ofm-AMSA ando-AMSA with nucleic acids: influence of ionic strength and DNA base composition [PDF]

, 1989
Randy M. Wadkins, David E. Graves
openalex   +1 more source

Design Principles of Nanosensors for Multiplex Detection of Contaminants in Food

Small, EarlyView.
This review discusses recent advancements in nanoparticle‐based nanosensors for multiplex detection of food contaminants, focusing on toxins and pathogens. It highlights the design principles, sensitivity, and selectivity of these sensors, offering insights into their practical applications for food safety monitoring and inspiring future innovations ...
Yang Zhang, Shipeng Gao, Haoran Li, Tianxi Yang, Kaiyi Zheng, Zhing Ming Guo, Jiyong Shi, Xiaowei Huang, Xiaobo Zou, Pierre Picchetti, Frank Biedermann   +10 more
wiley   +1 more source

Functional and Structural Analyses of Diverse G‐Quadruplex and Non‐G‐Quadruplex Structures Formed by Guanine‐Rich Nucleic Acids: A Study on the Insulin Aptamer

Small, EarlyView.
IGA3, a guanine‐rich insulin aptamer, adopts different structures depending on environmental conditions. Under low cation concentrations, IGA3 forms a non‐G‐quadruplex structure that interacts with insulin. This finding highlights that guanine‐rich nucleic acids, in structures other than G‐quadruplex, can also bind to proteins, revealing valuable ...
Naoya Iwano, Taiji Oyama, Mizuki Tomizawa, Shintaro Inaba, Ryuma Mori, Yasumoto Nakazawa, Koji Sode, Kaori Tsukakoshi, Takayuki Nakano, Kazunori Ikebukuro   +9 more
wiley   +1 more source

Surface Localized Coacervation Controlled by Bioactive Nanoarchitectonic Polyelectrolyte Multilayers

Small, EarlyView.
Using enzymatically active nanoarchitectured polyelectrolyte multilayers (PEMs), localized liquid–liquid phase separation can be directed from a so‐modified surface. In the presence of urea, PEM‐containing urease layers generate a pH gradient near the surface resulting in the self‐coacervation of a model peptide‐based coacervator.
Jean‐Yves Runser, Shahaji H. More, Robin Weiss, Christophe Contal, Alexis Bigo‐Simon, Maximilien Masquelier, Vincent Ball, Bernard Senger, Caroline Bertagnolli, Pierre Schaaf, Loïc Jierry   +10 more
wiley   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Polyethylene Glycol Nanofiller for Robust Lyophilization of Graphically Encoded Hydrogel Microparticles

Small, EarlyView.
The polyethylene glycol (PEG) nanofiller exerts a superior stabilization effect on the geometries and porous structures of the graphically encoded hydrogel microparticles in a lyophilization process. The as‐lyophilized microparticles can exert robust immunoassay performances (limit of detection: 6.48 pg mL−1) after thermal aging treatment, which ...
Wookyoung Jang, Ji Won Byun, Jun Hee Choi, Bolam Kim, Ki Wan Bong   +4 more
wiley   +1 more source