Results 91 to 100 of about 34,544 (276)

Capturing the essence of folding and functions of biomolecules using Coarse-Grained Models

, 2011
The distances over which biological molecules and their complexes can function range from a few nanometres, in the case of folded structures, to millimetres, for example during chromosome organization. Describing phenomena that cover such diverse length,
A Dhar, A Elcock, A Elcock, A Grosberg, A Grosberg, A Minton, A Pisliakov, A Podtelezhnikov, A Rychkova, A Savelyev, A Vologodskii, AA Podtelezhnikov, B Messer, BJ Alder, C Bustamante, C Clementi, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, D Thirumalai, D Thirumalai, D Thirumalai, D Thirumalai, D Thirumalai, E Koculi, E Lieberman-Aiden, E O'Brien, E Shakhnovich, EP O'Brien, F Valle, G Lorimer, G Papoian, G Ziv, H Liu, H Ma, HX Zhou, I Tinoco Jr., J Chen, J Harms, J Karanicolas, J Straub, JD Honeycutt, JM Fernandez, JN Onuchic, KA Dill, M Levitt, M Mickler, M Strajbl, M Takano, ME Fisher, MJ Todd, MS Cheung, N Hirokawa, N Koga, N Toan, OK Dudko, P Weinkam, PB Moore, PC Whitford, Q Du, R Russell, R Tehver, R Tehver, RD Vale, RD Vale, RI Dima, RW Pastor, S Jun, S Jun, S Jun, S Kamerlin, S Kirkpatrick, S Moghaddam, SB Smith, SJ Chen, SJ Marrink, T Cloutier, T Cremer, T Kirkpatrick, T Veitshans, V Lubchenko, Z Liu, Z Xu   +89 more
core   +1 more source

Contributions of the Histidine Side Chain and the N-Terminal α-Amino Group to the Binding Thermodynamics of Oligopeptides to Nucleic Acids as a Function of pH [PDF]

, 2010
Jeff D. Ballin, James P. Prevas, Christina R. Ross, Eric A. Toth, Gerald M. Wilson, M. Thomas Record   +5 more
openalex   +1 more source

Primordial RNA Replication and Applications in PCR Technology [PDF]

, 2013
The emergence of self-replication and information transmission in life's origin remains unexplained despite extensive research on the topic. A hypothesis explaining the transition from a simple organic world to a complex RNA world is offered here based ...
Palasek, Stan
core  

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials

BMEMat, EarlyView.
Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang, Yefei Dai, Yujun Hou, Joshua Stein, Shichen Steven Lin, Chaochen Zhou, Yannan Hou, Rongrong Zhu, Ki‐Bum Lee, Letao Yang   +9 more
wiley   +1 more source

Experimental Measurement of the Thermodynamics Underlying the Surface-Induced Structural Changes of Nucleic Acids and Proteins [PDF]

, 2016
Martin Kurnik, Netzahualcóyotl Arroyo, Hui Li, Di Kang, Kevin W. Plaxco   +4 more
openalex   +1 more source

Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications

ChemBioChem, EarlyView.
Glycosaminoglycans (GAGs) are linear, anionic biopolymers with their functions tightly linked to their charge. This review approaches GAGs from a polyelectrolyte perspective, shedding light on how the distribution of sulfate groups and, thus, negative charges, governs their interactions with other biomolecules.
Gergo Peter Szekeres, Eunjin Moon, Johanna K. Elter, Bryce Roper, Jayachandran Narayanan Nair Kizhakkedathu, Matthias Ballauff, Rainer Haag, Kevin Pagel   +7 more
wiley   +1 more source

Aldehyde or Hydrate? Investigation into the Oxidation of 5‐Formylcytosine Derivatives Using a Computational and Experimental Approach

ChemBioChem, EarlyView.
Hydrate‐mediated oxidation of 5‐formyl nucleobases by the iron(IV)‐oxido complex proceeds via geminal diol intermediates, accelerating hydrogen‐atom transfer and revealing aza‐dependent kinetic and mechanistic pathways. This study investigates the oxidation of 5‐hydroxymethyl and 5‐formyl nucleobases using an iron(IV)‐oxido complex that mimics the ...
Kuangjie Liu, Annika Menke, Fabian L. Zott, Domenic Mayer, Lena J. Daumann, Hendrik Zipse   +5 more
wiley   +1 more source

Model‐Based Optimization of Fed‐Batch In Vitro Transcription

ChemBioChem, EarlyView.
Using a mathematical model for the enzyme kinetics and solution thermodynamics of the in vitro transcription reaction, new optimized strategies are developed for fed‐batch transcription that can decrease the resource costs of mRNA synthesis while maintaining critical quality attributes for efficacy in vivo.
Nathan Merica Stover, Soroush Ahmadi, Jacob Rosenfeld, Francesco Destro, Allan S. Myerson, Richard D. Braatz   +5 more
wiley   +1 more source

Gold‐Mediated Base Pairs in Nucleic Acids: Selective Coordination to Natural and Thiocarbonyl‐Modified Cytosines Dependent upon the Oxidation State of Gold

ChemBioChem, EarlyView.
Selective coordination of gold ions to mismatched cytosines in nucleic acid duplexes is achieved via oxidation‐state‐dependent interactions. While Au(I) binds to natural cytosine–cytosine pairs, cytosine thiolation promotes square‐planar coordination with Au(III), offering a structure‐guided approach to redox‐tunable nucleic acid architectures.
Kai Kosugi, Ayano Sugawara, Erika Iwase, HeeJu Park, Shoji Fujiwara, Hiroki Kanazawa, Akira Ono, Jiro Kondo   +7 more
wiley   +1 more source