Results 111 to 120 of about 55,484 (212)

Rapid Amplification and Detection of Single‐Stranded Nucleic Acids for Point‐of‐Care Diagnosis

Small Methods, EarlyView.
A rapid, point‐of‐care nucleic acid test can greatly benefit healthcare system by providing timely diagnosis for effective treatment and patient management, as well as supporting diseases surveillance for emerging pandemic diseases. Recent advancements in nucleic acids technology have led to rapid assays for single‐stranded nucleic acids that can be ...
Jinglin Fu, Qiaochu Zhang, Shiming Liu, Derek Puyat, Akshay Shah, Alireza Ebrahimimojarad, Sung Won Oh   +6 more
wiley   +1 more source

Molecular characterization and structural basis of a promiscuous glycosyltransferase for β‐(1,6) oligoglucoside chain glycosides biosynthesis

Plant Biotechnology Journal, EarlyView.
We highlight a novel multi‐step O‐glycosyltransferase, UGT94BY1, which exhibits high promiscuity toward triterpene saponins and flavonoid glycosides for the formation of β‐(1,6) oligoglucoside chains. Through crystal structure analysis and theoretical calculations, we uncovered the mechanisms underlying substrate promiscuity and sugar chain extension ...
Zhennan Jiang, Nianhang Chen, Hao‐Tian Wang, Yungang Tian, Xiaoyu Du, Ruibo Wu, Luqi Huang, Zi‐Long Wang, Yuan Yuan   +8 more
wiley   +1 more source

Spatiotemporal Control Over Circadian Rhythms With Light

Medicinal Research Reviews, Volume 45, Issue 3, Page 968-984, May 2025.
ABSTRACT Circadian rhythms are endogenous biological oscillators that synchronize internal physiological processes and behaviors with external environmental changes, sustaining homeostasis and health. Disruption of circadian rhythms leads to numerous diseases, including cardiovascular and metabolic diseases, cancer, diabetes, and neurological disorders.
Dušan Kolarski, Wiktor Szymanski, Ben L. Feringa   +2 more
wiley   +1 more source

Metabolism‐inspired chemical reaction networks for chemically driven dissipative oligoesterification

Angewandte Chemie, Volume 137, Issue 14, April 1, 2025.
Behind the seemingly simple process of dissipative oligoesterification is a complex network of chemical reactions. Within this network, oligoesters undergo parasitic exchanges, consuming one another to sustain the system's dynamic state—an emergent behavior reminiscent of the self‐sustaining processes observed in natural metabolism. Abstract Metabolism
Yeonsoo Lim, Gyunam Park, Hojin An, Jonghwa Han, Joonhyun Bae, Ji‐Hyun Kim, Yan Lee, Kyungtae Kang, Jaeyoung Sung, Sunbum Kwon   +9 more
wiley   +2 more sources

Tunable G‐Quadruplex Ligands: Azobenzene Derivatives for Light‐Controlled DNA Modulation

Chemistry – A European Journal, Volume 31, Issue 23, April 22, 2025.
Azobenzene (AB) is a promising light‐responsive motif for targeting G‐quadruplexes (G4 s) and enabling their light‐controlled modulation. We synthesized a series of novel AB derivatives with diverse structural variations, demonstrating that the interaction mode influences its ability to modulate G4 properties bidirectionally.
Aleksandra Matusiak, Mateusz Drąg, Marco Deiana, Mikołaj J. Janicki, Marta Dudek   +4 more
wiley   +1 more source

Unraveling the Molecular Basis for G‐Quadruplex‐Binders to ALS/FTD‐Associated G4C2 Repeats of the C9orf72 Gene

ChemBioChem, Volume 26, Issue 8, April 14, 2025.
Some neurodegenerative disorders can be driven by recurrent mutations in the C9orf72 gene. These sequences can fold into G‐quadruplex secondary structures. Here, by performing in silico investigations coupled with FRET DNA melting assays, we unraveled the molecular basis for the selectivity of a series of organic and organometallic C9orf72 G4‐binders ...
Luisa D'Anna, Darren Wragg, Daniela Mauro, Simona Rubino, Alessio Terenzi, Giampaolo Barone, Sophie R. Thomas, Angela Casini, Riccardo Bonsignore, Angelo Spinello   +9 more
wiley   +1 more source

On the thermodynamics and kinetics of the cooperative binding of bacteriophage T4-coded gene 32 (helix destabilizing) protein to nucleic acid lattices

, 1980
S C Kowalczykowski, Nils Lönberg, John W. Newport, Leland S. Paul, Peter H. von Hippel   +4 more
openalex   +1 more source

Assembly and Functionality of 2D Protein Arrays

Advanced Science, Volume 12, Issue 15, April 17, 2025.
2D protein arrays‐based outstanding properties, including their remarkable structural stability, exceptional physiochemical properties, and tunable electronic and mechanical attributes, have become a key functional platform for developing advanced functional materials.
Mingming Du, Fanmeng Zeng, YueFei Wang, Ying Li, Guangcun Chen, Jiang Jiang, Qiangbin Wang   +6 more
wiley   +1 more source

Exploring the relationship between aptamer binding thermodynamics, affinity, and specificity. [PDF]

Nucleic Acids Res
Alkhamis O, Byrd C, Canoura J, Bacon A, Hill R, Xiao Y.   +5 more
europepmc   +1 more source

Fundamentals and Applications of Dual‐Frequency Magnetic Particle Spectroscopy: Review for Biomedicine and Materials Characterization

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Superparamagnetic nanoparticles show non‐linear magnetization behavior. Thus, they respond with magnetic intermodulation frequencies upon dual‐frequency magnetic excitation. These uniquely characterize their hydrodynamic and core sizes as well as binding states.
Hans‐Joachim Krause, Ulrich M. Engelmann   +1 more
wiley   +1 more source