Results 131 to 140 of about 221,973 (265)

Surface‐Driven Protocell Formation in Geologically Relevant Early Earth Environment

ChemSystemsChem, Volume 8, Issue 2, March 2026.
Illustration of a prebiotic early‐Earth environment showing cell‐like protocells (blue spheres) and other complex organic molecules (pink and green spheres) distributed across terrestrial surfaces and within subsurface niches. Volcanic landscapes and mineral‐rich substrates provide diverse geochemical settings for the assembly and evolution of ...
Pamela Knoll, Silvia Holler
wiley   +1 more source

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

Molecular Crowding‐Driven RNA Condensates Enable Förster Resonance Energy Transfer‐Enhanced Small‐Molecule Sensing

Aggregate, Volume 7, Issue 2, February 2026.
This study presents a dynamic‐responsive sensing system composed of RNA aptamers and polymers for adaptive histamine sensing. Programmable RNA self‐assembly via PEG8K enables phase‐separated condensates with enhanced stability and affinity. A label‐free FRET system (ThT→HBC dyes) achieves high‐sensitive detection (15.36 nM) in complex matrices ...
Yifan Wu, Xuan Ma, Yanger Liu, Zhaoxuan Zhang, Yangzi Zhang, Wenqiang Zhang, Longjiao Zhu, Wentao Xu   +7 more
wiley   +1 more source

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar, Sepideh Ahmadi, Nikzad Abbariki, Navid Rabiee, Sidi A. Bencherif   +4 more
wiley   +1 more source

Microarray based real-time analysis of nucleic acid hybridization kinetics and thermodynamics

, 2011
Siegfried Krainer
openalex   +1 more source

Preferential Solvation by Trifluoroethanol Drives α‐Helical Folding in the Disordered S2 Region of the Escargot Protein

ChemPhysChem, Volume 27, Issue 3, February 2026.
A disordered S2 region of the Escargot protein forms helices which are stabilized by TFE and are correlated with molecular recognition. The N‐terminal domain of the Drosophila melanogaster Escargot transcription factor (Esg) is an intrinsically disordered region (IDR) that complements the DNA‐binding activity of its C‐terminal zinc fingers. Within this
Vinicius Piccoli, Ander F. Pereira, Lina Rivillas‐Acevedo, Nina Pastor, Ángel E. Peláez‐Aguilar, Leandro Martínez   +5 more
wiley   +1 more source

Transient Cyclic Structured Oligonucleotide Designs for Therapeutic Applications

Current Protocols, Volume 6, Issue 2, February 2026.
Abstract Oligonucleotide‐based therapeutics are now widely used in clinical settings. From the late 1980s to the mid‐1990s, efforts to improve therapeutic efficacy focused on imparting drug‐like properties to oligonucleotides, emphasizing nuclease stability and target sequence affinity.
Sudhir Agrawal
wiley   +1 more source

Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods

MedComm, Volume 7, Issue 2, February 2026.
This review explores the recent advancements in applying computational methods to optimize mRNA vaccines, with a primary focus on improvements in sequence design and delivery systems. ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells.
Ruichu Gu, Duanmiao Si, Dingwei Lei, Xiaoxue Xie, Yongge Li, Han Wen   +5 more
wiley   +1 more source

Hydrogels for Cancer Immunotherapy: Strategies From Construction to Application

MedComm, Volume 7, Issue 2, February 2026.
Hydrogels offer an innovative platform for cancer immunotherapy. Through tailorable crosslinking strategies, they form customizable drug delivery platforms that address diverse therapeutic requirements by loading specific immunotherapeutic agents. These systems demonstrate significant clinical potential for precise tumor immunotherapy.
Xiaohua Chen, Shan Wu, Yueyang Zhang, Lilu Feng, Yang Chen, Xuzhao Yang, Ke Men, Jiuqun Zhu, Ming Li   +8 more
wiley   +1 more source

Concentration‐dependent mutational scanning probes the cellular folding landscape of α‐synuclein in yeast

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The misfolding and aggregation of α‐synuclein is a central molecular event in the etiology of Parkinson's disease and related disorders. α‐synuclein misfolding and pathology are both concentration‐dependent, but it is not clear precisely how changes in concentration alter the folding landscape within cells. Whereas most conventional structural
Daeun Noh, Robert W. Newberry
wiley   +1 more source