Results 131 to 140 of about 34,544 (276)

Thermodynamic factors in the synthesis of two-stranded nucleic acids. [PDF]

Proceedings of the National Academy of Sciences, 1966
openaire   +3 more sources

Peptide nucleic acid biosensors: Structure–interface interactions, electrochemical signal strategies, and diagnostic applications

VIEW, EarlyView.
This review discusses the structural and functional properties of peptide nucleic acid (PNA)‐based biosensors, emphasizing their sensitivity, enzymatic resistance, and diagnostic potential. It presents a comparative analysis of detection limits across sensor designs, focusing on probe immobilization, electrode composition, and signal amplification. The
Younghwan Kim, Swomitra Kumar Mohanty
wiley   +1 more source

ASOG: AntiSense Oligonucleotide Generator. [PDF]

Comput Struct Biotechnol J
Kimi J, Korczak P, Vialet B, Roubin E, Barthélémy P, Campagne S, Malard F.   +6 more
europepmc   +1 more source

On the thermodynamics and kinetics of the cooperative binding of bacteriophage T4-coded gene 32 (helix destabilizing) protein to nucleic acid lattices

, 1980
S C Kowalczykowski, Nils Lönberg, John W. Newport, Leland S. Paul, Peter H. von Hippel   +4 more
openalex   +1 more source

DNA Encoding Optimisation Based on Thermodynamics

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Due to their exceptional programmability, DNA molecules are widely employed in the design of molecular circuits for applications such as DNA computing, DNA storage and cancer diagnosis and treatment. The quality of DNA sequences directly determines the reliability of these molecular circuits.
Xianhang Luo, Kai Zhang, Enqiang Zhu, Jin Xu   +3 more
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Temperature-dependent funnel-like DNA folding landscapes. [PDF]

Nucleic Acids Res
Rico-Pasto M, Ribezzi-Crivellari M, Ritort F.   +2 more
europepmc   +1 more source

Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression

The FEBS Journal, EarlyView.
Genes repressed by the Polycomb system display greater chromatin folding compared to ‘regular’ inactive genes. The associated chromatin compaction, driven by PRC1‐H3K27me3 interactions, is modest and dynamic. This questions traditional models where Polycomb proteins repress transcription by sheltering genes from transcriptional activators.
Ludvig Lizana, Yuri B. Schwartz
wiley   +1 more source

Fitness landscapes and thermodynamic approaches to development of nucleic acids enzymes: from classical methods to AI integration. [PDF]

RSC Chem Biol
Takahashi S, Hamada M, Tateishi-Karimata H, Sugimoto N.   +3 more
europepmc   +1 more source