Results 131 to 140 of about 34,496 (157)
Some of the next articles are maybe not open access.
Thermodynamic Studies of Amsacrine Antitumor Agents with Nucleic Acids
1990The equilibrium binding of several anilinoacridine analogs are compared over a wide range of ionic strengths and temperatures. Although o-AMSA binds DNA with a higher affinity than m-AMSA it is not effective as an antitumor agent. Both m-AMSA and o-AMSA bind DNA in an intercalative manner.
D. E. Graves, R. M. Wadkins
openaire +1 more source
Statistical thermodynamics of nucleic acid melting transitions with coupled binding equilibria
Biopolymers, 1971AbstractEquations are developed to describe the shift in the temperature of the helix–coil transition when small molecules bind to nucleic acids. Included are high polymers, oligonucleotides, and oligomer–polymer interactions. The equations prescribe simple ways of plotting experimental data to evaluate transition and binding parameters.
openaire +2 more sources
[Thermodynamic characteristics of nucleic acid complexes with silver ions].
Biofizika, 1981By means of mixing reaction calorimetry the enthalpy of the complexes formation between Ag+ ions and DNA and dsRNA was measured. It was shown that Ag+ ions are able to form two types of complexes (I and II) with dsRNA. Using the method of the competitive reaction with chloride ions the stability constants of complex formation were obtained for dsRNA-Ag+
K A, Minasian +2 more
openaire +1 more source
Thermodynamics and Kinetics‐Directed Regulation of Nucleic Acid‐Based Molecular Recognition
Small MethodsAbstractNucleic acid‐based molecular recognition plays crucial roles in various fields like biosensing and disease diagnostics. To achieve optimal detection and analysis, it is essential to regulate the response performance of nucleic acid probes or switches to match specific application requirements by regulating thermodynamics and kinetics properties.
Yihao Liu +5 more
openaire +2 more sources
Tumour fatty acid metabolism in the context of therapy resistance and obesity
Nature Reviews Cancer, 2021Andrew J Hoy +2 more
exaly
Molecular modeling and thermodynamics simulation of nucleic acids
2016Nucleic acids participate in many cellular processes. DNA is responsible for gene heredity and its structure is mainly in double helix, whereas RNA has wide functions in gene transcription and regulation so its structures are varied among species.
openaire +1 more source
Mechanisms of retinoic acid signalling and its roles in organ and limb development
Nature Reviews Molecular Cell Biology, 2015Thomas J Cunningham, Gregg Duester
exaly
Pharmacological modulation of nucleic acid sensors — therapeutic potential and persisting obstacles
Nature Reviews Drug Discovery, 2019Claire Vanpouille-Box, Lorenzo Galluzzi
exaly
Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria
Nature Reviews Microbiology, 2008Jerry M Wells, Annick Mercenier
exaly