Results 11 to 20 of about 35,141 (270)

Thermodynamics of Nucleic Acid Structural Modifications for Biotechnology Applications

, 2011
The repertoire of chemistry available to native nucleotides in DNA and RNA is limited to the purine and pyrimidine functional groups, along with the special role of the 2’-hydroxyl of RNA. The nucleobases have exocyclic amino groups and imines, neither of which is highly reactive or a good candidate for catalytic function.
Stefan Franzen
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Theoretical Modeling of the Redox Thermodynamics of Nucleic Acid Building Blocks in the Condensed Phase. [PDF]

J Phys Chem B
Olivieri A, Nardi AN, D'Abramo M.
europepmc   +3 more sources

Thermodynamic analysis of Zα domain-nucleic acid interactions [PDF]

Biochemical Journal, 2022
AbstractDNA/RNA molecules adopting the left-handed conformation (Z-form) have been attributed with immunogenic properties. However, their biological role and importance has been a topic of debate for many years. The discovery of Z-DNA/RNA binding domains (Zα domains) in varied proteins that are involved in the innate immune response, such as the ...
Bharath Srinivasan, Krzysztof Kuś, Alekos Athanasiadis   +2 more
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Molecular modeling and thermodynamics simulation of nucleic acids

, 2016
Nucleic acids participate in many cellular processes. DNA is responsible for gene heredity and its structure is mainly in double helix, whereas RNA has wide functions in gene transcription and regulation so its structures are varied among species.
You Xu
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Thermodynamic Analysis of Nylon Nucleic Acids [PDF]

ChemBioChem, 2008
AbstractThe stability and structure of nylon nucleic acid duplexes with complementary DNA and RNA strands was examined. Thermal denaturing studies of a series of oligonucleotides that contained nylon nucleic acids (1–5 amide linkages) revealed that the amide linkage significantly enhanced the binding affinity of nylon nucleic acids towards both ...
Yu, Liu, Risheng, Wang, Liang, Ding, Ruojie, Sha, Philip S, Lukeman, James W, Canary, Nadrian C, Seeman   +6 more
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NTDB: Thermodynamic Database for Nucleic Acids [PDF]

Nucleic Acids Research, 2001
A new thermodynamic database for normal and modified nucleic acids has been developed. This Thermodynamic Database for Nucleic Acids (NTDB) includes sequence, structure and thermodynamic information as well as experimental methods and conditions. In this release, there are 1851 sequences containing both normal and modified nucleic acids.
W L, Chiu, C N, Sze, L N, Ip, S K, Chan, S C, Au-Yeung   +4 more
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Monovalent metal ion binding promotes the first transesterification reaction in the spliceosome

Nature Communications, 2023
Cleavage and formation of phosphodiester bonds in nucleic acids is accomplished by large cellular machineries composed of both protein and RNA. Long thought to rely on a two-metal-ion mechanism for catalysis, structure comparisons revealed many contain ...
Jana Aupič, Jure Borišek, Sebastian M. Fica, Wojciech P. Galej, Alessandra Magistrato   +4 more
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NTDB: Thermodynamic Database for Nucleic Acids, Version 2.0 [PDF]

Nucleic Acids Research, 2003
The second release of Thermodynamic Database for Nucleic Acids, NTDB 2.0, includes more than 4600 entries (250% increase over release 1.0). It contains sequence types and details of several thermodynamic parameters (enthalpy, DeltaH; entropy, DeltaS; Gibbs free energy, DeltaG; melting temperature, T(m)), experimental models and methods for extracting ...
Wing Lok Abe Kurtz, Chiu, Chun Ngai, Sze, Nap Tak, Ma, Lai Fan, Chiu, Chung Wai, Leung, Steve Chik Fun, Au-Yeung   +5 more
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Thermodynamic database for protein–nucleic acid interactions (ProNIT) [PDF]

Bioinformatics, 2001
Abstract Motivation: Protein–nucleic acid interactions are fundamental to the regulation of gene expression. In order to elucidate the molecular mechanism of protein–nucleic acid recognition and analyze the gene regulation network, not only structural data but also quantitative binding data are necessary.
P, Prabakaran, J, An, M M, Gromiha, S, Selvaraj, H, Uedaira, H, Kono, A, Sarai   +6 more
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Thermodynamic framework to assess low abundance DNA mutation detection by hybridization. [PDF]

PLoS ONE, 2017
The knowledge of genomic DNA variations in patient samples has a high and increasing value for human diagnostics in its broadest sense. Although many methods and sensors to detect or quantify these variations are available or under development, the ...
Hanny Willems, An Jacobs, Wahyu Wijaya Hadiwikarta, Tom Venken, Dirk Valkenborg, Nadine Van Roy, Jo Vandesompele, Jef Hooyberghs   +7 more
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