Results 11 to 20 of about 191,094 (249)

A more unified picture for the thermodynamics of nucleic acid duplex melting: A characterization by calorimetric and volumetric techniques [PDF]

open access: greenProceedings of the National Academy of Sciences of the United States of America, 1999
We use a combination of calorimetric and volumetric techniques to detect and to characterize the thermodynamic changes that accompany helix-to-coil transitions for five polymeric nucleic acid duplexes. Our calorimetric measurements reveal that melting of
Tigran V. Chalikian   +3 more
openalex   +2 more sources

What Controls the Hybridization Thermodynamics of Spherical Nucleic Acids? [PDF]

open access: greenJournal of the American Chemical Society, 2015
The hybridization of free oligonucleotides to densely packed, oriented arrays of DNA modifying the surfaces of spherical nucleic acid (SNA)-gold nanoparticle conjugates occurs with negative cooperativity; i.e., each binding event destabilizes subsequent ...
Pratik S. Randeria   +6 more
openalex   +2 more sources

Use of Differential Scanning Calorimetry (DSC) to Study the Thermodynamics of DNA-Based Interactions and Nucleic Acid-Based Therapeutics

open access: hybrid, 2016
In the 1950’s, the research findings of James Watson, Francis Crick, Rosalind Franklin, and Maurice Wilkins led to the discovery of the deoxyribonucleic acid (DNA) double-helix conformation [1,2].
Fidelis Manyanga
openalex   +2 more sources

Nucleic Acid Binding Thermodynamics and Functions of DNA Polymerases

open access: bronze, 2013
................................................................................................................................... iv CHAPTER 1. GENERAL INTRODUCTION ...............................................................................1 1.1 ...
Hiromi Brown
openalex   +3 more sources

Thermodynamics of Nucleic Acid Structural Modifications for Biotechnology Applications

open access: hybrid, 2011
The repertoire of chemistry available to native nucleotides in DNA and RNA is limited to the purine and pyrimidine functional groups, along with the special role of the 2’-hydroxyl of RNA. The nucleobases have exocyclic amino groups and imines, neither of which is highly reactive or a good candidate for catalytic function.
Stefan Franzen
openalex   +5 more sources

Expanding the Functions of KHSRP Protein: Insights into DNA G‐Quadruplex Binding [PDF]

open access: yesAdvanced Science
KHSRP (KH‐type splicing regulatory protein) is a multifunctional nucleic acid‐binding protein that regulates various cellular processes, with critical roles in controlling gene expression.
Pasquale Russomanno   +9 more
doaj   +2 more sources

Thermodynamic analysis of Zα domain-nucleic acid interactions [PDF]

open access: yesBiochemical Journal, 2022
AbstractDNA/RNA molecules adopting the left-handed conformation (Z-form) have been attributed with immunogenic properties. However, their biological role and importance has been a topic of debate for many years. The discovery of Z-DNA/RNA binding domains (Zα domains) in varied proteins that are involved in the innate immune response, such as the ...
Bharath Srinivasan   +2 more
openaire   +2 more sources

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