Results 11 to 20 of about 34,544 (276)
Thermodynamic Analysis of Interacting Nucleic Acid Strands [PDF]
SIAM Review, 2007 Motivated by the analysis of natural and engineered DNA and RNA systems, we present the first algorithm for calculating the partition function of an unpseudoknotted complex of multiple interacting nucleic acid strands. This dynamic program is based on a rigorous extension of secondary structure models to the multistranded case, addressing ...
Dirks, Robert M. +4 more
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Theoretical Modeling of the Redox Thermodynamics of Nucleic Acid Building Blocks in the Condensed Phase. [PDF]
J Phys Chem BOlivieri A, Nardi AN, D'Abramo M.
europepmc +2 more sources
Editorial: Thermodynamics and structure of nucleic acids with modified bases [PDF]
Biopolymers, 2002 Luis A. Marky
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Thermodynamic analysis of Zα domain-nucleic acid interactions [PDF]
Biochemical Journal, 2022 AbstractDNA/RNA molecules adopting the left-handed conformation (Z-form) have been attributed with immunogenic properties. However, their biological role and importance has been a topic of debate for many years. The discovery of Z-DNA/RNA binding domains (Zα domains) in varied proteins that are involved in the innate immune response, such as the ...
Bharath Srinivasan +2 more
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Thermodynamic Analysis of Nylon Nucleic Acids [PDF]
ChemBioChem, 2008 AbstractThe stability and structure of nylon nucleic acid duplexes with complementary DNA and RNA strands was examined. Thermal denaturing studies of a series of oligonucleotides that contained nylon nucleic acids (1–5 amide linkages) revealed that the amide linkage significantly enhanced the binding affinity of nylon nucleic acids towards both ...
James W. Canary +8 more
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NTDB: Thermodynamic Database for Nucleic Acids [PDF]
Nucleic Acids Research, 2001 A new thermodynamic database for normal and modified nucleic acids has been developed. This Thermodynamic Database for Nucleic Acids (NTDB) includes sequence, structure and thermodynamic information as well as experimental methods and conditions. In this release, there are 1851 sequences containing both normal and modified nucleic acids.
Steve C. F. Au-Yeung +4 more
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Monovalent metal ion binding promotes the first transesterification reaction in the spliceosome
Nature Communications, 2023 Cleavage and formation of phosphodiester bonds in nucleic acids is accomplished by large cellular machineries composed of both protein and RNA. Long thought to rely on a two-metal-ion mechanism for catalysis, structure comparisons revealed many contain ...
Jana Aupič +4 more
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Thermodynamic framework to assess low abundance DNA mutation detection by hybridization. [PDF]
PLoS ONE, 2017 The knowledge of genomic DNA variations in patient samples has a high and increasing value for human diagnostics in its broadest sense. Although many methods and sensors to detect or quantify these variations are available or under development, the ...
Hanny Willems +7 more
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Thermodynamic database for protein–nucleic acid interactions (ProNIT) [PDF]
Bioinformatics, 2001 Abstract Motivation: Protein–nucleic acid interactions are fundamental to the regulation of gene expression. In order to elucidate the molecular mechanism of protein–nucleic acid recognition and analyze the gene regulation network, not only structural data but also quantitative binding data are necessary.
M. Michael Gromiha +6 more
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