Results 31 to 40 of about 34,496 (157)

Probing Hybridization parameters from microarray experiments: nearest neighbor model and beyond [PDF]

, 2012
In this article it is shown how optimized and dedicated microarray experiments can be used to study the thermodynamics of DNA hybridization for a large number of different conformations in a highly parallel fashion.
Carlon, Enrico, Hadiwikarta, Wahyu W., Hooyberghs, Jef, Walter, Jean-Charles   +3 more
core   +3 more sources

Thermodynamic database for protein-nucleic acid interactions

Seibutsu Butsuri, 2000
Protein-nucleic acid interaction plays an essential role in the regulation of gene expression. Structural and binding information provides insight into the mechanism of protein-nucleic acid recognition. Although there are structural databases for protein-nucleic acid complexes, there exists no database for protein-nucleic acid binding.
Ponraj Prabakaran, J. An, M.Michael Gromiha, Samuel Selvaraj, H. Uedaira, H. Kono, A. Sarai   +6 more
openaire   +2 more sources

Improving model predictions for RNA interference activities that use support vector machine regression by combining and filtering features

BMC Bioinformatics, 2007
Background RNA interference (RNAi) is a naturally occurring phenomenon that results in the suppression of a target RNA sequence utilizing a variety of possible methods and pathways.
Peek Andrew S
doaj   +1 more source

Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot [PDF]

, 2017
The functions of RNA pseudoknots (PKs), which are minimal tertiary structural motifs and an integral part of several ribozymes and ribonucleoprotein complexes, are determined by their structure, stability and dynamics.
Ansari, Anjum, Baral, Saroj, Hori, Naoto, Narayanan, Prasanth, Narayanan, Ranjani, Roca, Jorjethe, Thirumalai, D., Velmurugu, Yogambigai   +7 more
core   +3 more sources

Modified RNA triplexes: Thermodynamics, structure and biological potential

Scientific Reports, 2018
The occurrence of triplexes in vivo has been well documented and is determined by the presence of long homopurine-homopyrimidine tracts. The formation of these structures is the result of conformational changes that occur in the duplex, which allow the ...
Marta Szabat, Elzbieta Kierzek, Ryszard Kierzek   +2 more
doaj   +1 more source

Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides [PDF]

Nucleic Acids Research, 2010
Thermodynamics provides insights into the influence of modified nucleotide residues on stability of nucleic acids and is crucial for designing duplexes with given properties. In this article, we introduce detailed thermodynamic analysis of RNA duplexes modified with unlocked nucleic acid (UNA) nucleotide residues.
Pasternak, Anna, Wengel, Jesper
openaire   +4 more sources

Force-induced misfolding in RNA [PDF]

, 2009
RNA folding is a kinetic process governed by the competition of a large number of structures stabilized by the transient formation of base pairs that may induce complex folding pathways and the formation of misfolded structures. Despite of its importance
D. Herschlag, F. Ritort, I. Junier, I. Tinoco, Jr., M. Manosas, P. J. Flory   +5 more
core   +3 more sources

Changes in Thermodynamic Parameters Induced by Pyrimidine Nucleic Bases Forming Complexes with Amino Acids and Peptides in a Buffer Solution at pH = 7.4

Liquids
This article presents a mini-review of the available data on the thermodynamics of the complexation of amino acids and peptides with some nucleic bases in a buffer medium.
Elena Yu. Tyunina, Vladimir P. Barannikov, Igor N. Mezhevoi   +2 more
doaj   +1 more source

Twist versus Nonlinear Stacking in Short DNA Molecules

, 2014
The denaturation of the double helix is a template for fundamental biological functions such as replication and transcription involving the formation of local fluctuational openings.
Zoli, Marco
core   +1 more source

Paradigms for computational nucleic acid design [PDF]

, 2004
The design of DNA and RNA sequences is critical for many endeavors, from DNA nanotechnology, to PCR‐based applications, to DNA hybridization arrays.
Dirks, Robert M., Lin, Milo, Pierce, Niles A., Winfree, Erik   +3 more
core   +5 more sources