Physico-chemical foundations underpinning microarray and next-generation sequencing experiments [PDF]
, 2013 Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next-generation sequencing (NGS).
A. Buhot +70 more
core +3 more sources
Study of E. coli Hfq's RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents [PDF]
, 2012 Folding of RNA molecules into their functional three-dimensional structures is often supported by RNA chaperones, some of which can catalyse the two elementary reactions helix disruption and helix formation.
Beich-Frandsen, Mads +6 more
core +1 more source
Viral genome structures are optimal for capsid assembly
eLife, 2013 Understanding how virus capsids assemble around their nucleic acid (NA) genomes could promote efforts to block viral propagation or to reengineer capsids for gene therapy applications.
Jason D Perlmutter +2 more
doaj +1 more source
Binding of threading intercalator to nucleic acids: Thermodynamic analyses [PDF]
Nucleic Acids Symposium Series, 2002 The constant melting temperature upon the change in the oligonucleotide concentration showed that the oligonucleotide d(CGCTTTGCG) formed a intramolecular hairpin rather than a duplex with an internal loop. We examined the thermodynamic properties of the interaction between the threading intercalator, naphthalene diimides designated as NDI, and a ...
Hidetaka, Torigoe +5 more
openaire +2 more sources
Nucleic acid-lipid membrane interactions studied by DSC
Journal of Pharmacy and Bioallied Sciences, 2011 The interactions of nucleic acids with lipid membranes are of great importance for biological mechanisms as well as for biotechnological applications in gene delivery and drug carriers. The optimization of liposomal vectors for clinical use is absolutely
Sarantis Giatrellis, George Nounesis
doaj +1 more source
Dynamics of Ionic Interactions at Protein–Nucleic Acid Interfaces
Accounts of Chemical Research, 2020 Conspectus Molecular association of proteins with nucleic acids is required for many biological processes essential to life. Electrostatic interactions via ion pairs (salt bridges) of nucleic acid phosphates and protein side chains are crucial for ...
Binhan Yu, B. Pettitt, J. Iwahara
semanticscholar +1 more source
The thermodynamic landscape of carbon redox biochemistry [PDF]
, 2018 Redox biochemistry plays a key role in the transduction of chemical energy in all living systems. Observed redox reactions in metabolic networks represent only a minuscule fraction of the space of all possible redox reactions.
Aspuru-Guzik, Alán +7 more
core +1 more source
Theory on the mechanism of DNA renaturation: Stochastic nucleation and zipping [PDF]
, 2015 Renaturation of complementary single strands of DNA is one of the important processes that requires better understanding in the view of molecular biology and biological physics.
Murugan, Rajamanickam +1 more
core +8 more sources
Robustness and modularity properties of a non-covalent DNA catalytic reaction [PDF]
, 2009 The biophysics of nucleic acid hybridization and strand displacement have been used for the rational design of a number of nanoscale structures and functions. Recently, molecular amplification methods have been developed in the form of non-covalent DNA
Aldaye +20 more
core +4 more sources
The origins and physical roots of life’s dual – metabolic and genetic – nature [PDF]
, 2017 This review paper aims at a better understanding of the origin and physical foundation of life’s dual – metabolic and genetic – nature. First, I give a concise ‘top-down’ survey of the origin of life, i.e., backwards in time from extant DNA/RNA/protein ...
De Tiège, Alexis
core +2 more sources