Results 51 to 60 of about 34,496 (157)
Expanding the Functions of KHSRP Protein: Insights into DNA G‐Quadruplex Binding
Advanced ScienceKHSRP (KH‐type splicing regulatory protein) is a multifunctional nucleic acid‐binding protein that regulates various cellular processes, with critical roles in controlling gene expression.
Pasquale Russomanno +9 more
doaj +1 more source
Encapsulation of a polymer by an icosahedral virus
, 2010 The coat proteins of many viruses spontaneously form icosahedral capsids around nucleic acids or other polymers. Elucidating the role of the packaged polymer in capsid formation could promote biomedical efforts to block viral replication and enable use ...
Elrad, Oren M., Hagan, Michael F.
core +1 more source
Counting the ions surrounding nucleic acids. [PDF]
, 2016 Nucleic acids are strongly negatively charged, and thus electrostatic interactions-screened by ions in solution-play an important role in governing their ability to fold and participate in biomolecular interactions.
Jacobson, David R, Saleh, Omar A
core +1 more source
Large scale analysis of protein stability in OMIM disease related human protein variants [PDF]
, 2016 Modern genomic techniques allow to associate several Mendelian human diseases to single residue variations in different proteins. Molecular mechanisms explaining the relationship among genotype and phenotype are still under debate.
Aggazio, Francesco +5 more
core +3 more sources
ProTherm and ProNIT: thermodynamic databases for proteins and protein-nucleic acid interactions [PDF]
Nucleic Acids Research, 2006 ProTherm and ProNIT are two thermodynamic databases that contain experimentally determined thermodynamic parameters of protein stability and protein-nucleic acid interactions, respectively. The current versions of both the databases have considerably increased the total number of entries and enhanced search interface with added new fields, improved ...
Kumar, M. D. Shaji +6 more
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Dynamics of Bacteriophage Genome Ejection In Vitro and In Vivo
, 2010 Bacteriophages, phages for short, are viruses of bacteria. The majority of phages contain a double-stranded DNA genome packaged in a capsid at a density of ~500 mg/ml. This high density requires substantial compression of the normal B form helix, leading
Molineux, Ian J., Panja, Debabrata
core +1 more source
A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code
, 2009 Of the twenty amino acids used in proteins, ten were formed in Miller's atmospheric discharge experiments. The two other major proposed sources of prebiotic amino acid synthesis include formation in hydrothermal vents and delivery to Earth via meteorites.
Chakrabarti S. +2 more
core +1 more source
The protein cost of metabolic fluxes: prediction from enzymatic rate laws and cost minimization
, 2016 Bacterial growth depends crucially on metabolic fluxes, which are limited by the cell's capacity to maintain metabolic enzymes. The necessary enzyme amount per unit flux is a major determinant of metabolic strategies both in evolution and bioengineering.
Bar-Even, Arren +5 more
core +3 more sources
Thermodynamics and Kinetics of Nucleic Acids Folding
, 2023 [spa] En este trabajo doctoral se han investigado las propiedades termodinámicas y cinéticas de los ácidos nucleicos. El principal objetivo era el estudio de los mecanismos de plegamiento que se llevan a cabo en la hibridación de moléculas de ADN y ARN y su caracterización energética. La tesis está organizada en cuatro partes principales. En la Parte I,
openaire +2 more sources