Results 81 to 90 of about 191,094 (249)
Chemistry – A European Journal, EarlyView.The insertion of a fluorescent coumarin unit by using a lysine‐based linker on deferoxamine leads to a chelating agent (DFOKC), whose Cu(II) and Zr(IV) complexes can be used for both optical imaging and positron emission tomography. DFOKC shows increased binding ability for Cu(II) and Zr(II) and improved tumor cell internalization via pinocytosis ...
Yschtar Tecla Simonini Steiner +8 more
wiley +1 more source
Chemistry – A European Journal, Accepted Article.The stability of pairwise tryptophan (Trp) edge‐to‐face aromatic interactions has been exploited in the design of small tryptophan zipper (Trpzip) peptides. Herein, we report a systematic study of the regiospecific impact of four constitutional isomers of non‐natural fluoro‐Trp, regarding their incorporation at either edge‐ or face‐position.
David Reiter +6 more
wiley +1 more source
Dual Excitation and Dual Emission in a 1,4‐Diazepine Bearing an Extended π‐System
Chemistry – A European Journal, Accepted Article.We present the synthesis of a benzo[b]benzo[11,12]tetracene[5,6‐ef][1,4]diazepine ( ClBBTDZ ) and a benzo[g]phenanthro[9,10,1‐cde]indazolium ( ClBPIZ ), two novel N‐heterocyclic nanographenes. Both molecules were independently isolated from 2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ)‐mediated cyclodehydrogenation reaction of the previously reported
Lars Killian +6 more
wiley +1 more source
Light‐Activated Molecules Targeting G‐Quadruplex Nucleic Acids
Chemistry – A European Journal, EarlyView.We shine a spotlight on the molecular recognition mechanisms and phototherapeutic potential of light‑activated compounds targeting G‑quadruplex nucleic acids, critically evaluating recent breakthroughs and charting the key challenges that must be overcome to drive this promising field forward.
Marta Dudek +2 more
wiley +1 more source
What can be learned from the electrostatic environments within nitrogenase enzymes?
Chemistry – A European Journal, Accepted Article.Nitrogen fixation is a fundamental, and yet challenging, chemical transformation due to the intrinsic inertness of dinitrogen. Whereas industrial ammonia synthesis relies on the energy‐intensive Haber–Bosch process, nitrogenase enzymes achieve this transformation under ambient conditions—yet at the expense of a remarkably high ATP demand. Understanding
Thijs Stuyver +3 more
wiley +1 more source
Tailored Watson–Crick Pairing Partners for Xanthosine in RNA
Chemistry – A European Journal, Accepted Article.The deamination of guanosine nucleobases results in the formation of xanthosine (X)‐containing RNA. This process formally resembles adenine deamination (A‐to‐I editing). The biological significance and basic chemical consequences of X‐modified RNA are poorly understood.
Ronald Micura +5 more
wiley +1 more source
Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy
ChemPlusChem, EarlyView.Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber +3 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT The increasing development and application of metal‐based materials in biomedical and environmental fields raise important concerns regarding their potential cytotoxic and genotoxic effects. Metal tungstates (MxWO4) and molybdates (MxMoO4) offer promising functional properties in health and environmental solutions but require safety validation
Marcelo Assis +6 more
wiley +1 more source
Thiol‐X Chemistry: A Skeleton Key Unlocking Advanced Polymers in Additive Manufacturing
Macromolecular Materials and Engineering, EarlyView.Additive manufacturing and thiol‐X chemistry form a powerful combination for fabricating a diverse array of advanced polymers to address contemporary engineering applications. Thiol‐X reactions offer versatile polymerization mechanisms, “click” reactivity, functional group tolerance, desirable properties, and compatibility over a broad range of 3D ...
James Anthony Dicks, Chris Woolard
wiley +1 more source