DNA‐binding properties of non‐intercalating water‐soluble organometallic Ir(III) luminophores
Chemistry – A European Journal, Accepted Article.A series of Ir(III) complexes, [Ir(C^N)2(en)]+ (where C^N = 2‐phenyl‐benzo[d]thiazolyl cyclometalating ligand; en = ethylene diamine), are reported with structural variation via a substituent (H, Me, OMe, Cl, OCF3) at the coordinated phenyl ring.
Ibrahim Alkhaibari +4 more
wiley +1 more source
The importance of thermodynamics for molecular systems, and the importance of molecular systems for thermodynamics [PDF]
arXiv, 2017 Improved understanding of molecular systems has only emphasised the sophistication of networks within the cell. Simultaneously, the advance of nucleic acid nanotechnology, a platform within which reactions can be exquisitely controlled, has made the development of artificial architectures and devices possible.
arxiv
Experimental Measurement of the Thermodynamics Underlying the Surface-Induced Structural Changes of Nucleic Acids and Proteins [PDF]
, 2016 Martin Kurnik +4 more
openalex +1 more source
Click Conjugates of Artificial Ribonucleases: Sequence Specific Cleavage with Multiple Turnover
Chemistry – A European Journal, Accepted Article.The azido modified RNA cleaving catalyst 2 has been attached to oligonucleotides containing alkyne linkers in a central position. The resulting conjugates hybridize specifically with complementary RNA strands and cleave them with multiple substrate turnover. RNA half‐lives are in the range of 6‐7 h (pH 8, 37 °C).
Sandra Weber +4 more
wiley +1 more source
Mechanism of thermal renaturation and hybridization of nucleic acids: Kramers process and universality in Watson-Crick base pairing [PDF]
arXiv, 2008 Renaturation and hybridization reactions lead to the pairing of complementary single-stranded nucleic acids. We present here a theoretical investigation of the mechanism of these reactions in vitro under thermal conditions (dilute solutions of single-stranded chains, in the presence of molar concentrations of monovalent salts and at elevated ...
arxiv
Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides [PDF]
, 2010 Anna Pasternak, Jesper Wengel
openalex +1 more source
Chemistry – A European Journal, Accepted Article.Telomeric DNA forms G‐quadruplex (G4) structures. These G4s structures are crucial for genomic stability and therapeutic targeting. Using time‐resolved NMR and CD spectroscopies, we investigated how the ligand Phen‐DC3 modulates the folding of the human telomeric repeat 23TAG DNA.
Ines Burkhart +3 more
wiley +1 more source
Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy
ChemPlusChem, Accepted Article.The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber +3 more
wiley +1 more source
A more unified picture for the thermodynamics of nucleic acid duplex melting: A characterization by calorimetric and volumetric techniques [PDF]
, 1999 Tigran V. Chalikian +3 more
openalex +1 more source