Results 81 to 90 of about 34,544 (276)

A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code

, 2009
Of the twenty amino acids used in proteins, ten were formed in Miller's atmospheric discharge experiments. The two other major proposed sources of prebiotic amino acid synthesis include formation in hydrothermal vents and delivery to Earth via meteorites.
Chakrabarti S., Paul G. Higgs, Ralph E. Pudritz   +2 more
core   +1 more source

The Limitation of the Combination of Transition State Theory and Thermodynamics for the Reactions of Proteins and Nucleic Acids [PDF]

, 2021
Nobuo Shimamoto
openalex   +1 more source

Marginal Stability of the YB1 Cold‐Shock Domain in Cells Enables Binding of Multiple Nucleic Acids

Advanced Science, EarlyView.
This study suggests that the marginal stability of the YB1 Cold‐Shock Domain (CSDex) allows for a balance between multifunctionality and conformational changes under physiological conditions. This balance is driven by the dynamic equilibrium between the unfolded ensemble (UE) and the native ensemble (NE) of CSDex (PDB:6LMR).
Puja Shrestha, Sara S. Ribeiro, Janne Aurich, Christian Herrmann, Simon Ebbinghaus   +4 more
wiley   +1 more source

Phenylboronic Acid‐Modified Copper Nanozymes as Nanoscavengers of Bacterial Polysaccharides Causing Acute Lung Injury

Advanced Science, EarlyView.
A novel copper nanocluster coated with 4‐mercaptobenzeneboronic acid (CuMPBA) is developed to target bacterial polysaccharides for addressing complicated acute lung injury (ALI) caused by severe burns and early pulmonary infections. CuMPBA exhibits dual anti‐inflammatory and antibacterial mechanisms by: (a) binding and degrading toxic bacterial ...
Haojie Ge, Min Wang, Haijiao Xie, Xu‐Lin Chen, Xianwen Wang   +4 more
wiley   +1 more source

Dynamics of Bacteriophage Genome Ejection In Vitro and In Vivo

, 2010
Bacteriophages, phages for short, are viruses of bacteria. The majority of phages contain a double-stranded DNA genome packaged in a capsid at a density of ~500 mg/ml. This high density requires substantial compression of the normal B form helix, leading
Molineux, Ian J., Panja, Debabrata
core   +1 more source

Pushing Biomolecule Detection Limit With Graphene Field‐effect Transistor Biosensors

Advanced Electronic Materials, EarlyView.
Graphene knows your health! This work presents a comprehensive overview of recent advances in graphene field‐effect transistor (GFET) biosensors for ultrasensitive biomolecule detection. How device engineering, high‐mobility graphene synthesis, and tailored surface chemistry push detection limits is highlighted, while discussing emerging strategies ...
Co Dang Pham, Quang Thang Trinh, Jun Zhang, Nam‐Trung Nguyen, Tuan‐Khoa Nguyen   +4 more
wiley   +1 more source

Photoactivatable Synthetic Exosomes for RNA‐Based Communication Between Artificial Cells and Living Cells

Angewandte Chemie, EarlyView.
This article describes a modular strategy to construct artificial cells able to regulate mammalian cell protein expression via vesicle‐based RNA communication. Considering the important role of extracellular vesicles in genetic information transfer, this artificial exosome design is a significant advance toward mimicking nucleic acid communication ...
Alexander B. Cook, Siwen Sun, Yudong Li, Jari Scheerstra, Jan C.M. van Hest   +4 more
wiley   +2 more sources

Green Synthesis of Silver Nanoparticles: A Review of Polymer and Antimicrobial Drug Combinations for Enhanced Antimicrobial Applications

Advanced NanoBiomed Research, EarlyView.
Silver nanoparticles (AgNPs) synthesized using eco‐friendly green synthesis approaches exhibit remarkable antimicrobial activity and enhanced drug delivery potential. Polymer‐AgNPs conjugates further improve drug stability and targeted delivery, offering a multifunctional platform for biomedical applications.
Mukil Madhusudanan, Jian Zhang, Santosh Pandit, Priyanka Singh, Geum‐Jae Jeong, Fazlurrahman Khan, Ivan Mijakovic   +6 more
wiley   +1 more source

The protein cost of metabolic fluxes: prediction from enzymatic rate laws and cost minimization

, 2016
Bacterial growth depends crucially on metabolic fluxes, which are limited by the cell's capacity to maintain metabolic enzymes. The necessary enzyme amount per unit flux is a major determinant of metabolic strategies both in evolution and bioengineering.
Bar-Even, Arren, Davidi, Dan, Flamholz, Avi, Liebermeister, Wolfram, Milo, Ron, Noor, Elad   +5 more
core   +3 more sources

Nucleic Acid‐Based Molecular Machines for Biological Applications

Advanced NanoBiomed Research, EarlyView.
Molecular machines are devices assembled from molecules with specific functions. In this review, the development of DNA nanostructures, which are then assembled into molecular machines, is summarized. Their classification and biological applications, such as biosensing, targeted therapy, and molecular circuits are introduced.
Yirong Guo, Xiaolei Zuo, Fangfei Yin
wiley   +1 more source