Results 211 to 220 of about 1,094,037 (343)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Antibacterial activities of novel peptide nucleic acids targeting <i>Salmonella</i> penicillin-binding proteins. [PDF]

Mol Ther Nucleic Acids
El-Fateh M, Viau C, Ahmed N, Xia J, Zhao X.   +4 more
europepmc   +1 more source

THE IDENTIFICATION OF THREE MONONUCLEOTIDES FROM TOBACCO MOSAIC VIRUS NUCLEIC ACID

, 1947
C. E. Schwerdt, Hubert S. Loring
openalex   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Opening new frontiers with catalytic nucleic acids in miRNA inhibition. [PDF]

Front Pharmacol
Patutina O, Miroshnichenko S, Chiglintseva D, Zenkova M.   +3 more
europepmc   +1 more source

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source

Aptamer-mediated liver-targeted curcumin delivery system based on tetrahedral framework nucleic acids for NAFLD. [PDF]

Drug Deliv
Chen S, Liu Y, Ma S, Chen L, Zhou L, Wang J, Huang Y, Yu Z, Dou X.   +8 more
europepmc   +1 more source

Nucleic Acid Encoding A Lectin-Derived Progenitor Cell Preservation Factor

, 2023
M Gabriella Colucci, Maarten J. Chrispeels, Jeffrey G. Moore   +2 more
openalex   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Homogenization of cartilage tumors to extract total RNA to microarray and sequencing analysis using Precellys bead-beating technology

BioTechniques, 2012
Guillaume Banneau, Mira Ayadi, Lucile Armenoult, Esmeralda Carvalho   +3 more
doaj   +1 more source