Results 41 to 50 of about 6,062,195 (387)
Molecules, 2021 RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently ...
Yaroslav Staroseletz +7 more
doaj +1 more source
Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core +1 more source
Nature Materials, 2016 Nucleic acid memory has a retention time far exceeding electronic memory. As an alternative storage media, DNA surpasses the information density and energy of operation offered by flash memory.
Zhirnov, Victor +4 more
openaire +4 more sources
Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model
Frontiers in Pharmacology, 2019 Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases ...
Olga A. Patutina +7 more
doaj +1 more source
Atomic Structures of Molecules Based on Additivity of Atomic and/or Ionic Radii [PDF]
, 2009 The authors have shown in recent years that interatomic and interionic distances are sums of the radii of the adjacent atoms and/or ions. Many examples will be provided and it will be shown how the experimental bond lengths agree with the radii sums. The
Raji Heyrovska, Sara Narayan
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Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos
Frontiers in Bioengineering and Biotechnology, 2020 The translational therapies to promote interaction between cell and signal come with stringent eligibility criteria. The chemically defined, hierarchically organized, and simpler yet blessed with robust intermolecular association, the peptides, are ...
Seema Gupta +4 more
doaj +1 more source
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. [PDF]
, 2008 Mammalian Toll-like receptors (TLRs) 3, 7, 8 and 9 initiate immune responses to infection by recognizing microbial nucleic acids; however, these responses come at the cost of potential autoimmunity owing to inappropriate recognition of self nucleic acids.
Barton, Gregory M +6 more
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The Nucleic Acid Database: A Resource for Nucleic Acid Science [PDF]
Acta Crystallographica Section D Biological Crystallography, 1998 The Nucleic Acid Database (NDB) distributes information about nucleic acid-containing structures. Here the information content of the database as well as the query capabilities are described. A summary of how the technology developed by this project has been used to develop other macromolecular databases is given.
John D. Westbrook +2 more
openaire +3 more sources
Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. [PDF]
, 2015 Aicardi-Goutières syndrome (AGS) is a severe childhood inflammatory disorder that shows clinical and genetic overlap with systemic lupus erythematosus (SLE).
Chédin, Frédéric +4 more
core +2 more sources
Insights into DNA platination within unusual structural settings [PDF]
, 2011 2D [1H, 15N] HSQC NMR spectroscopy has been used to monitor reaction and product formation between [Pt(15NH3)2I2] and nucleic acids possessing irregular topologies and containing site specific phosphorothioate substitution in the phosphodiester backbone.
Harvie, Stephanie +2 more
core +2 more sources