Results 61 to 70 of about 7,473,748 (355)
An Extended Dot-Bracket-Notation for Functional Nucleic Acids
, 2008 Functional nucleic acids are an attractive substrate for molecular computing. A nucleic acid molecule is a linear chain of covalently bound building blocks assembled in arbitrary order from a set of typically four nucleotides.
Zauner, Klaus-Peter, Ramlan, Effirul I.
core +1 more source
Understanding biochemistry: structure and function of nucleic acids
Essays in Biochemistry, 2019 Nucleic acids, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), carry genetic information which is read in cells to make the RNA and proteins by which living things function. The well-known structure of the DNA double helix allows this information
S. Minchin, J. Lodge
semanticscholar +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Nucleic acids in sediment core 54301-019
, 2009 Nucleic acids in sediment core 54301 ...
Danovaro, Roberto +3 more
core +1 more source
Metal carcinogens and cancer: integrating genetic and epigenetic perspectives
Frontiers in OncologyPeople around the globe are affected by extensive environmental and occupational exposure to heavy metals, which poses a significant threat to various health hazards, with cancer being a major concern.
Shipra Singh +6 more
doaj +1 more source
Journal of Nucleic Acids, 2011 Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains. The effects of these side-chains on the conformations
Matthew J. Crawford +4 more
doaj +1 more source
Signal Transduction and Targeted TherapyThe ability of small nucleic acids to modulate gene expression via a range of processes has been widely explored. Compared with conventional treatments, small nucleic acid therapeutics have the potential to achieve long-lasting or even curative effects ...
Mo-Han Liu +6 more
semanticscholar +1 more source
Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids.
Annual Review of Microbiology, 2018 Microbial infections are recognized by the innate immune system through germline-encoded pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or RNA during their life cycle, nucleic acid sensing has evolved as an essential ...
Xiao-Jun Tan +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Nucleic acids in sediment core 54301-002
, 2009 Nucleic acids in sediment core 54301 ...
Danovaro, Roberto +3 more
core +1 more source