Results 81 to 90 of about 7,473,748 (355)

Structural insights into a DNA polymerase reading the xeno nucleic acid HNA [PDF]

Xeno nucleic acids (XNAs) are unnatural analogues of the natural nucleic acids in which the canonical ribose or deoxyribose rings are replaced with alternative sugars, congener structures or even open-ring configurations. The expanding repertoire of XNAs
Marx, Andreas (author), Herdewijn, Piet, Coosemans, Frédérick, Herdewijn, Piet (author), Gutfreund, Cedric, Marx, Andreas, Holliger, Phillipp (author), Abramov, Mikhail, Holliger, Phillipp, Gutfreund, Cédric (author), Betz, Karin (author), Abramov, Mikhail (author), Betz, Karin, Coosemans, Frédérick (author)   +13 more
core   +1 more source

Probing three-dimensional cyclooctatetraene for nucleobase modification in aptamer selection

Communications Chemistry
Decoration of aptamers with chemical modifications at the level of nucleobases grants access to alternative binding modes, which often result in improved binding properties.
Greta Charlotte Dahm, Usman Akhtar, Alix Bouvier-Müller, Laura Lim, Fabienne Levi-Acobas, Pierre Nicolas Bizat, Germain Niogret, Julian A. Tanner, Frédéric Ducongé, Marcel Hollenstein   +9 more
doaj   +1 more source

Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids.

Annual Review of Cell and Developmental Biology, 2018
Microbial nucleic acids are major signatures of invading pathogens, and their recognition by various host pattern recognition receptors (PRRs) represents the first step toward an efficient innate immune response to clear the pathogens.
Ming-Ming Hu, H. Shu
semanticscholar   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin

, 2016
The nuclear immunophilin FKBP25 interacts with chromatin-related proteins and transcription factors and is suggested to interact with nucleic acids. Currently the structural basis of nucleic acid binding by FKBP25 is unknown.
Yoon, Ho Sup, Shin, Joon, Rajan, Sreekanth, Prakash, Ajit   +3 more
core   +1 more source

Nucleic acids and analogs for bone regeneration

Bone Research, 2018
With the incidence of different bone diseases increasing, effective therapies are needed that coordinate a combination of various technologies and biological materials.
Yu-Xin Zhang, Wenjuan Ma, Yuxi Zhan, Chenchen Mao, X. Shao, Xueping Xie, Xia-Wei Wei, Yun-Feng Lin   +7 more
semanticscholar   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cytoplasmic circular dsDNA is a key constituent of stress granules

eLife
Stress granules are large cytoplasmic bodies formed in response to environmental insults by eukaryotic cells. Stress granule formation is key for post-stress recovery, and many diseases and infections are characterized by dysregulation of these ...
Natalia A Demeshkina, Adrian R Ferré-D'Amaré   +1 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Quadruplex nucleic acids as targets for anticancer therapeutics

, 2017
Quadruplex nucleic acids — helical four-stranded structures known to form from guanine-rich nucleic acid sequences through Hoogsteen-type hydrogen bonding — were once just laboratory curiosities.
S. Neidle
semanticscholar   +1 more source