Results 71 to 80 of about 516,976 (317)

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber, Troiber, Christina, Wagner, Ernst, Ernst Wagner   +3 more
core   +1 more source

Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

Nature Communications, 2017
Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a ...
Susan E. Tsutakawa, Mark J. Thompson, Andrew S. Arvai, Alexander J. Neil, Steven J. Shaw, Sana I. Algasaier, Jane C. Kim, L. David Finger, Emma Jardine, Victoria J.B. Gotham, Altaf H. Sarker, Mai Z. Her, Fahad Rashid, Samir M. Hamdan, Sergei M. Mirkin, Jane A. Grasby, John A. Tainer   +16 more
doaj   +1 more source

Design of interacting multi-stable nucleic acids for molecular information processing

, 2011
Despite an exponential increase in computing power over the past decades, present information technology falls far short of expectations in areas such as cognitive systems and micro robotics.
Zauner, Klaus-Peter, Klaus-Peter Zauner, Ramlan, Effirul I., Ramlan, E.I., Effirul I. Ramlan, Zauner, K.P.   +5 more
core   +1 more source

New strategies in Bioconjugation : chemical modification of nucleic acids and peptides [PDF]

, 2015
One of the open challenges in chemical biology is to identify reactions that proceed with large rate constants in water at neutral pH values. Once assembled, these conjugates may be used for a broad variety of applications (e.g., therapeutics, imaging ...
Schmidt, Pascal Jarno
core   +1 more source

A High-Throughput Workflow for Mass Spectrometry Analysis of Nucleic Acids by Nanoflow Desalting

, 2023
Broad interest in nucleic acids – both their therapeutic capabilities and understanding the nuances of their structure and resulting function – has increased in recent years.
Jennifer, Brodbelt, Michael, Lanzillotti
core   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Exploring RNA modifications in infectious non-coding circular RNAs

RNA Biology
Viroids, small circular non-coding RNAs, act as infectious pathogens in higher plants, demonstrating high stability despite consisting solely of naked RNA.
Pavel Vopalensky, Anton Škríba, Michela Chiumenti, Lucia Ďuričeková, Anna Šimonová, Ondřej Lukšan, Francesco Di Serio, Beatriz Navarro, Hana Cahova   +8 more
doaj   +1 more source

Modulation and Recognition of Nucleic Acid Structures

, 2012
The fidelity of an organism’s genome is central to biology. DNA, however, is constantly being damaged and modified by a variety of sources. As a result of these changes, repair enzymes, polymerases, and other interrogating biomolecules must be able to ...
Spring, Alexander M
core   +1 more source

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response

Cell Reports, 2016
Through an RNAi-based screen for previously uncharacterized regulators of genome stability, we have identified the human protein C5orf45 as an important factor in preventing the accumulation of DNA damage in human cells.
Christopher J. Staples, Giancarlo Barone, Katie N. Myers, Anil Ganesh, Ian Gibbs-Seymour, Abhijit A. Patil, Ryan D. Beveridge, Caroline Daye, Richard Beniston, Sarah Maslen, Ivan Ahel, J. Mark Skehel, Spencer J. Collis   +12 more
doaj   +1 more source