Results 101 to 110 of about 23,431 (250)
New Insight into Photophysics of DNA Nucleobases
, 2016 Using broadband deep-UV transient absorption and electronic 2D spectroscopies we found that in all DNA nucleobases the photodeactivation of excited-state population occurs in two steps via a “dark” state which presumably is a nπ ...
R.J. Dwayne Miller +5 more
core +1 more source
Site‐Specific Enzymatic Syntheses of DNA Bearing Several Modifications From RNA or DNA Templates
Chemistry – A European Journal, EarlyView.A single‐tube protocol for enzymatic synthesis of DNA containing 1–3 site‐specific nucleobase modifications was developed based on repeated single nucleotide extension, primer extension, and exchange of template. ABSTRACT Two approaches for the enzymatic synthesis of DNA oligonucleotides (ONs) bearing multiple site‐specific modifications were explored.
Lukáš Kaiser +2 more
wiley +1 more source
Citation: 'nucleobase' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09710 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
European Journal of Inorganic Chemistry, EarlyView.This work explores the influence of 6‐trifluoromethyluracil versus chloride counterions on the antibacterial and antitumoral activities of bis‐(1,10‐phenanthroline)chloridecopper(II) motif. The counterion modulates antibacterial potency and the identity of the dominant reactive species, while leaving DNA recognition by the shared cation essentially ...
Francisco Mastrobuono‐Cordeiro +14 more
wiley +1 more source
6-Methyluracil: a redetermination of polymorph (II)
IUCrData, 2019 6-Methyluracil, C5H6N2O2, exists in two crystalline phases: form (I), monoclinic, space group P21/c [Reck et al. (1988). Acta Cryst. A44, 417–421] and form (II), monoclinic, space group C2/c [Leonidov et al. (1993). Russ. J. Phys. Chem.
Gustavo Portalone
doaj +1 more source
Insights into the electrochemical behaviour of brominated RNA nucleobases at microband screen-printed graphite electrodes [PDF]
Nucleobases are nitrogenous compounds that form nucleotides, the building blocks of DNA and RNA. Modification of DNA and RNA through various epigenetic mechanisms can occur at different levels and plays a fundamental role in several biological processes;
Gomis-Berenguer, A +7 more
core +2 more sources
Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li +7 more
wiley +1 more source
DERA-Catalyzed Chemoenzymatic Access to Nucleobase-Substituted Candidate Statin Precursors
BiomoleculesAldolases are powerful biocatalysts for the stereoselective formation of carbon–carbon bonds and are widely used in the synthesis of chiral intermediates for pharmaceutical applications.
Romina Fernández Varela +9 more
doaj +1 more source
Molecules, 2015 A reliable ultra-high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry (UHPLC–ESI–MS/MS) method for the fast simultaneous determination of 13 nucleosides and nucleobases in Cordyceps sinensis (C.
Shi-Yu Zong +6 more
doaj +1 more source
Proton Transfer in Nucleobases is Mediated by Water
, 2016 Water plays a central role in chemistry and biology by mediating the interactions between molecules, altering energy levels of solvated species, modifying potential energy profiles along reaction coordinates, and facilitating efficient proton transport ...
Kirill Khistyaev (1927258) +5 more
core +1 more source