Results 71 to 80 of about 23,431 (250)

Syntheses of 15N-labeled pre-queuosine nucleobase derivatives

Beilstein Journal of Organic Chemistry, 2014
Pre-queuosine or queuine (preQ1) is a guanine derivative that is involved in the biosynthetic pathway of the hypermodified tRNA nucleoside queuosine (Que). The core structure of preQ1 is represented by 7-(aminomethyl)-7-deazaguanine (preQ1 base).
Jasmin Levic, Ronald Micura
doaj   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

Stability and Reactivity of Alternative Nucleobases in Concentrated Sulfuric Acid

Molecules
Recent findings demonstrate that concentrated sulfuric acid supports rich organic chemistry, including the stability of the canonical DNA bases adenine, thymine, guanine and cytosine.
Jingcheng Huang, Sara Seager, Maxwell D. Seager, Janusz J. Petkowski   +3 more
doaj   +1 more source

Dual-tip-enhanced ultrafast CARS nanoscopy

New Journal of Physics, 2014
Coherent anti-Stokes Raman scattering (CARS) and, in particular, femtosecond adaptive spectroscopic techniques (FAST CARS) have been successfully used for molecular spectroscopy and microscopic imaging.
Charles W Ballmann, Bin Cao, Alexander M Sinyukov, Alexei V Sokolov, Dmitri V Voronine   +4 more
doaj   +1 more source

Potential use of LIAD time-of-flight mass spectrometry for the detection of biomolecules: An example of detecting nucleobases in DNA

AIP Advances, 2023
Deoxyribonucleic acid (DNA) carries the genetic information necessary for the synthesis of RNA and proteins; it is a biological macromolecule essential for the development and proper functioning of living organisms and is composed of nucleobases ...
Qiaolin Wang, Lihe Xu, Zhengbo Qin, Xinyan Yang, Xianfeng Zheng   +4 more
doaj   +1 more source

Complex structures synthesized in shock processing of nucleobases – implications to the origins of life

, 2021
Nucleobases are nitrogenous bases composed of monomers that are a major constituent of RNA and DNA, which are an essential part of any cellular life on the Earth.
Jayaram, V., Samarth, P., Bhardwaj, Anil, Surendra, V. S., Sivaraman, B., Muruganantham, M., Vijay, T., Vijayan, S., Mason, N. J., Hill, H.   +9 more
core   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

Nucleobases and corresponding nucleosides display potent antiviral activities against dengue virus possibly through viral lethal mutagenesis. [PDF]

PLoS Neglected Tropical Diseases, 2018
Dengue virus affects millions of people worldwide each year. To date, there is no drug for the treatment of dengue-associated disease. Nucleosides are effective antivirals and work by inhibiting the accurate replication of the viral genome.
Li Qiu, Steven E Patterson, Laurent F Bonnac, Robert J Geraghty   +3 more
doaj   +1 more source

Biocatalysed halogenation of nucleobase analogues

Biotechnology Letters, 2011
The synthesis of halogenated nucleosides and nucleobases is of interest due to their chemical and pharmacological applications. Herein, the enzymatic halogenation of nucleobases and analogues catalysed by microorganisms and by chloroperoxidase from Caldariomyces fumago has been studied.
Médici, Rosario, Garaycoechea, Juan Ignacio, Dettorre, Lucas Andrés, Iribarren, Adolfo Marcelo, Lewkowicz, Elizabeth Sandra   +4 more
openaire   +3 more sources

Modeling the vibrational couplings of nucleobases

The Journal of Chemical Physics, 2020
Vibrational spectroscopy, in particular infrared spectroscopy, has been widely used to probe the three-dimensional structures and conformational dynamics of nucleic acids. As commonly used chromophores, the C=O and C=C stretch modes in the nucleobases exhibit distinct spectral features for different base pairing and stacking configurations.
Yaoyukun Jiang, Lu Wang
openaire   +5 more sources