Results 171 to 180 of about 84,247 (263)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, Volume 7, Issue 5, October 2026.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Analysis of Virologic and Clinical Predictors for Hospitalization, Supported by Machine Learning, in a Phase 3 Molnupiravir COVID‐19 Treatment Trial

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Machine learning (ML) is increasingly being used in clinical medicine. The objective of this study was to identify factors predictive of hospitalization, with the support of ML, in outpatients with mild‐to‐moderate COVID‐19. Unvaccinated adults with mild‐to‐moderate COVID‐19 were randomized 1:1 to molnupiravir or placebo in MOVe‐OUT ...
Matthew G. Johnson, Jessica M. Conway, Laura E. Liao, David W. Hilbert, Erin Jensen, Dorothy McCoy, Yanfen Guan, Ying Zhang, Michelle L. Brown, Dana D. Byrne, Carisa De Anda   +10 more
wiley   +1 more source

Characterisation of HIV‐1 Gag Cytotoxic T‐Lymphocyte Epitopes in the Southern African Region—A Systematic Review

Immunology, Volume 179, Issue 2, Page 165-184, October 2026.
Distribution of studies on HIV‐1 Gag cytotoxic T‐lymphocyte epitopes in the southern African region showing that the majority of studies (58.44%) were conducted in South Africa, followed by Botswana (15.58%), Zambia (10.39%), Malawi (7.79%), Zimbabwe (6.49%), and Angola (1.30%).
Tumelo L. Fortuin, Paballo Nkone, Shayne Loubser, Caroline T. Tiemessen, Simnikiwe H. Mayaphi   +4 more
wiley   +1 more source

PARP3 Promotes SARS-CoV-2 Replication via Interaction with the Viral Nucleocapsid Protein. [PDF]

Kobe J Med Sci
Adyaksa DNM, Rhamadianti AF, Deng L, Abe T, Matsui C, Shoji I.   +5 more
europepmc   +1 more source

Turnip mosaic virus utilizes the lipid droplet biogenesis machinery to facilitate its propagation in plants

New Phytologist, Volume 252, Issue 2, Page 797-816, October 2026.
Potyvirus turnip mosaic virus induces neutral lipid accumulation and lipid droplet biogenesis in infected leaves for its own benefit. See also the Commentary on this article by May & Nagy, 252: 525–527. Summary Lipid droplets (LDs), which are dedicated to storing neutral lipids (NLs), are dynamic organelles involved in numerous other functions ...
Léna Jambou, Nathalie Arvy, Marguerite Batsale, Luc Sofer, Sara Shakir, Marielle Cochet, Vincent Simon, Charlotte Quinteau, Thomas Scotti, Nathan M. Doner, Satinder K. Gidda, Robert T. Mullen, Sabine D'Andréa, Jean‐Luc Gallois, Denis Coulon, Claire Bréhélin, Sylvie German‐Retana   +16 more
wiley   +1 more source

Hepatitis B virus infection with high HBsAg and undetectable DNA levels in untreated blood donors: Viral mechanisms and transfusion safety implications

Transfusion, Volume 66, Issue 10, Page 1993-2006, October 2026.
Abstract Background Blood donor screening occasionally identifies individuals with high HBV surface antigen (HBsAg) levels despite undetectable or extremely low HBV DNA. Molecular basis and transfusion risk of this discordant profile remain unclear. Study Design and Methods Seventy‐five blood donors with HBsAg >100 IU/mL and undetectable or very low ...
Maelenn Païline Delcourt, Marion Vermeulen, Aneta Kopacz, Manuela Miletic, Andrew Saville, Christoph Niederhauser, Jean‐Michel Pawlotsky, Syria Laperche, Daniel Candotti   +8 more
wiley   +1 more source

The Innate Antiviral Factors APOBEC3G and APOBEC3H Interact with the Nucleocapsids of Human Coronaviruses in an RNA-Dependent Manner. [PDF]

Viruses
Exposito Trivino J, Decloux A, Renier M, Massart T, Petit J, Collard M, Willemart K, Sellier A, Tesse R, Kindylides S, Twizere JC, Nicaise C, Tafforeau L, Gillet NA.   +13 more
europepmc   +1 more source

Affinity Selection of MS2 VLPs as SARS-CoV-2 Vaccine Candidates Targeting Nucleocapsid Protein. [PDF]

Viruses
Peabody J, Ye C, Bradfute S, Chackerian B, Peabody DS.   +4 more
europepmc   +1 more source

Computational Analysis of Immunohistochemistry Enables Quantitative Assessment of SARS-CoV-2 Nucleocapsid Immunolabeling in Experimentally Infected Mice. [PDF]

Viruses
Kozarac N, Botos M, Burgener L, de Brot S, Brito F, Berenguer Veiga I, Taddeo A, Devisme C, Bagatella S, Ebert N, Barut GT, Moreira ÉA, Leborgne NGF, Brügger M, Thiel V, Benarafa C, Grau-Roma L.   +16 more
europepmc   +1 more source

Linear antibody epitope prediction using AlphaFold2. [PDF]

Elife
DeRoo J, Terry JS, Zhao N, Stasevich TJ, Snow C, Geiss BJ.   +5 more
europepmc   +1 more source