Results 151 to 160 of about 79,219 (253)

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, Volume 73, Issue 8, August 2026.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Deep Mutational Scanning for the Study and Engineering of Protein Assemblies

Chemistry–Methods, Volume 6, Issue 8, August 2026.
This review explores how deep mutational scanning (DMS) can be used to improve understanding and accelerate engineering of protein assemblies, from natural fibers to engineered nanocages. We discuss various types of protein assemblies and their characterization, provide an introduction to the DMS technique, and then highlight examples in which DMS has ...
Jenna B. Wolfanger, Shoili Banerjee, Carolyn E. Mills   +2 more
wiley   +1 more source

Impact of ABO Blood System on Immunogenicity and Vaccine Efficacy of COVID‐19 Booster Vaccination—A Population‐Based Study of 3066 Individuals

Influenza and Other Respiratory Viruses, Volume 20, Issue 8, August 2026.
ABSTRACT Background ABO blood group has been associated with SARS‐CoV‐2 susceptibility. Little data exist regarding the impact of ABO and Rhesus (Rh[D]) type on breakthrough infections and antibody responses following SARS‐CoV‐2 booster vaccination. Methods This multicenter, population‐based cohort study includes individuals ≥ 18 years who received a ...
Daniela Sieghart, Galateja Jordakieva, Caroline Dürrschmid, Claudia A. Hana, Lan Vi Tran, Leonhard X. Heinz, Helmuth Haslacher, Markus Zlesak, Valentin Marzoner, Philip Nasztl, Giulia Piccini, Alessandro Manenti, Emanuele Montomoli, Anselm Jorda, Clemens Fedrizzi, Timothy Hasenoehrl, Andrej Zdravkovic, Karolina Anderle, Ursula Wiedermann, Susanne Drapalik, Helmut Steinbrecher, Felix Bergmann, Christa Firbas, Barbara Wagner, Margherita Leonardi, Giulio Pierleoni, Matilde Ballini, Linda Benincasa, Serena Marchi, Claudia Maria Trombetta, Thomas Perkmann, Richard Crevenna, Markus Zeitlinger, Michael Bonelli, Daniel Aletaha, Helga Radner   +35 more
wiley   +1 more source

Characterization of SARS-CoV-2 nucleocapsid protein oligomers [PDF]

Oligomers of the SARS-CoV-2 nucleocapsid (N) protein are characterized by pronounced instability resulting in fast degradation. This property likely relates to two contrasting behaviors of the N protein: genome stabilization through a compact ...
Farci, Domenica,, Kereïche, Sami,, Hall, Michael, Schröder, Wolfgang P, Haniewicz, Patrycja,, Faull, Peter,, Schröder, Wolfgang P.,, Graça, André T.,, Piano, Dario,, Haniewicz, Patrycja, Kirkpatrick, Joanna,, Hall, Michael,, Faull, Peter, Graça, André T, Piano, Dario, Tramontano, Enzo,, Farci, Domenica, Kereïche, Sami, Kirkpatrick, Joanna, Tramontano, Enzo   +19 more
core   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

Suppression of SARS-CoV-2 nucleocapsid protein dimerization by ISGylation and its counteraction by viral PLpro

Frontiers in Microbiology
Protein modification by the ubiquitin-like protein ISG15 (ISGylation) plays a crucial role in the immunological defense against viral infection. During severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, innate immune signaling ...
Wonjin Bang, Jaehyun Kim, Kanghun Seo, Jihyun Lee, Ji Ho Han, Daegyu Park, Jae Hwan Cho, Donghyuk Shin, Kyun-Hwan Kim, Moon Jung Song, Jin-Hyun Ahn   +10 more
doaj   +1 more source

Design and Synthesis of Novel Imidazo[4,5‐c]pyridine Derivatives, Evaluation of Their Activity Against Hepatitis C Virus and In Silico Prediction of Their Binding Mode to NS4B Protein

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 18 novel imidazo[4,5‐c]pyridines was synthesized, and their anti‐HCV activity was evaluated. Compound 30b was identified as the most promising one, with EC50 = 6.61 µM. Molecular docking studies indicated the NS4B protein of the HCV as a potential target of these derivatives.
Eftychia Karampella, George Mpekoulis, Maria Georgiou, Iris Kolida, Katerina I. Kalliampakou, Eirini P. Kollia, Eleni V. Mikropoulou, Maria Halabalaki, Christos T. Chasapis, Niki Vassilaki, Nikolaos Lougiakis   +10 more
wiley   +1 more source

Hepatitis B Virus Nucleocapsid Assembly

Journal of Molecular Biology
Hepatitis B virus (HBV), the prototypical member of the Hepadnaviridae family, is a DNA virus that replicates its genome through reverse transcription of a pregenomic RNA (pgRNA) precursor. The selective packaging of pgRNA and viral polymerase (Pol) into assembling capsids formed by the viral core protein-a process known as nucleocapsid assembly-is an ...
Hong, Xupeng, Schneider, William M., Rice, Charles M.   +2 more
openaire   +2 more sources

Structural basis for Ebola virus nucleocapsid assembly and function regulated by VP24 [PDF]

エボラウイルス粒子の「中核」構造を解明 --VP24タンパク質の異なる結合様式がウイルス増殖制御のカギに-- . 京都大学プレスリリース. 2025-03-11.The Ebola virus, a member of the Filoviridae family, causes severe hemorrhagic fever in humans.
Houri, Kazuya, Sugita, Y., Ng, Yen Ni, Houri, K., Fujita-Fujiharu, Y., Muramoto, Yukiko, Fujita-Fujiharu, Yoko, Nakano, Masahiro, Takamatsu, Y., Muramoto, Y., Noda, Takeshi, Nakano, M., Noda, T., Sugita, Yukihiko, Hu, Shangfan, Hirabayashi, Ai, Takamatsu, Yuki, Ng, Y., Hu, S., Hirabayashi, A.   +19 more
core   +1 more source