Results 131 to 140 of about 82,632 (214)

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

Characterization of SARS-CoV-2 nucleocapsid protein oligomers [PDF]

Oligomers of the SARS-CoV-2 nucleocapsid (N) protein are characterized by pronounced instability resulting in fast degradation. This property likely relates to two contrasting behaviors of the N protein: genome stabilization through a compact ...
Farci, Domenica,, Kereïche, Sami,, Hall, Michael, Schröder, Wolfgang P, Haniewicz, Patrycja,, Faull, Peter,, Schröder, Wolfgang P.,, Graça, André T.,, Piano, Dario,, Haniewicz, Patrycja, Kirkpatrick, Joanna,, Hall, Michael,, Faull, Peter, Graça, André T, Piano, Dario, Tramontano, Enzo,, Farci, Domenica, Kereïche, Sami, Kirkpatrick, Joanna, Tramontano, Enzo   +19 more
core   +1 more source

Ursodeoxycholic Acid Reduces Angiotensin‐Converting Enzyme 2 Activity and Suppresses Cytokine Storm Syndrome in Patients With Coronavirus Disease 2019

MedComm, Volume 7, Issue 9, September 2026.
SARS‐CoV‐2 infection causes COVID‐19 and stimulates immune cells, such as dendritic cells, monocytes, and macrophages, to increase levels of many cytokines. Ursodeoxycholic acid (UDCA) inhibits farnesoid X receptor (FXR), resulting in a decrease in the activity of angiotensin‐converting enzyme 2 (ACE2), the main receptor on the membrane for SARS‐CoV‐2.
Zhaowei Tong, Jiawei Zhu, Jianfeng Zhong, Qi Wang, Fuchu Qian, Lili Zhao, Weihong Wang, Yuepao Cai, Kefeng Qin   +8 more
wiley   +1 more source

The C117D oxidation mimic reveals the monomeric structure of SARS‐CoV‐2 main protease

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The SARS‐CoV‐2 main protease (Mpro) is essential for viral replication and functions as a homodimer, with dimerization being critical for catalytic activity. Mpro contains an unusually high number of cysteine residues. Among these, C117 and the catalytic nucleophile C145 can form a reversible disulfide bond under oxidative conditions.
Sam Andress, Matthew J. McLeod, Todd Holyoak   +2 more
wiley   +1 more source

Sequence‐encoded determinants drive distinct early aggregation pathways and different structural outcomes in PNT1 fibrils across Henipavirus members

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Protein aggregation is increasingly recognized as a biologically relevant process in viral proteins, yet the molecular determinants governing such phenomena remain poorly understood. Intrinsically disordered proteins (IDPs) are ubiquitous in viral proteomes, where conformational plasticity not only enables functional diversity but also permits
Harshita Sawdekar, Julien Mignon, Frank Gondelaud, Anuja Walimbe, Samrat Mukhopadhyay, Joseph Chamieh, Sonia Longhi   +6 more
wiley   +1 more source

Investigations into the mechanisms involved in baculovirus nucleocapsid egress

, 2016
The mechanism of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) nucleocapsid egress from the nucleus to the plasma membrane leading to the formation of budded virus (BV) is not known.
Biswas, Siddhartha
core   +1 more source

The Changing Landscape of Hantavirus Infections: A Narrative Review of Epidemiology, Pathogenesis, and Countermeasures

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria, Francesco Branda, Giancarlo Ceccarelli, Fabio Scarpa, Massimo Ciccozzi, Alessandro Russo   +5 more
wiley   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Molecular Epidemiology of Peste des Petits Ruminants Virus Circulating in Fat‐Tailed Sheep in Bangladesh

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This study reports the molecular detection and genetic characterization of peste des petits ruminants virus in fat‐tailed sheep in Bangladesh. Phylogenetic analysis reveals transboundary lineage circulation, highlighting silent virus movement during high‐risk livestock trading periods and the need for strengthened regional surveillance.
Md. Arif Khan, Pronesh Dutta, Md. Kaisar Rahman, Abdullah‐Al Mamun, Jade K. Forwood, Shariful Islam, Ariful Islam   +6 more
wiley   +1 more source

Writing Big in Plant Genomes: Advances, Challenges and Strategies for Targeted Large‐Fragment DNA Insertion

Plant, Cell &Environment, Volume 49, Issue 9, Page 6506-6520, September 2026.
ABSTRACT Precise genome editing has transformed plant biology and crop improvement by enabling targeted modification of endogenous loci. Beyond gene knockout and base editing, the site‐specific insertion of exogenous DNA, particularly large DNA fragments, has become a central goal for engineering complex traits, reconstructing metabolic pathways and ...
Fengfeng Zhang, Daqi Yan, Jiayi Hou, Dan Yang, Yan Xiong, Mingzhang Wen, Xiaoyue Zhu   +6 more
wiley   +1 more source