Results 131 to 140 of about 84,247 (263)

Naturally Occurring ZCCHC3 Variants Modulate Antiretroviral Activity in Cynomolgus Macaques

Microbiology and Immunology, EarlyView.
ABSTRACT Many mammalian cells restrict viral replication by utilizing various host restriction factors. We recently demonstrated that CCHC‐type zinc‐finger‐containing protein 3 (ZCCHC3) suppresses human immunodeficiency virus type 1 (HIV‐1) replication through multiple mechanisms.
Jacob Fadipe, Tomotaka Okamura, Shige H. Yoshimura, Akatsuki Saito   +3 more
wiley   +1 more source

Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination

Allergy, EarlyView.
We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera, Benjamin Schwarz, Brittany Dulek, Ian S. LaCroix, Min Li, Lindsay Chatman, Muhammad B. Khalid, Ellen Zektser, Karen Laky, Stella Hartono, Eric Bohrnsen, Cole D. Kimzey, Eric Chu, Roa Harb, Pamela A. Frischmeyer‐Guerrerio   +14 more
wiley   +1 more source

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

Prediction of linear B cell epitopes for nucleocapsid protein from different SFTSV strains.

, 2014
Prediction of linear B cell epitopes for nucleocapsid protein from different SFTSV strains.
Shibo Li (550898), Lei Zhang (38117), Yanjun Zhang (168997), Cen feng (5661097), Ling Ye (111749), Xiuyu Lou (652073), Yi Sun (118759), Chengwei Wang (652074), David M. Ojcius (167589), Zhongfa Wang (652075)   +9 more
core   +1 more source

Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors [PDF]

, 2015
RNA or DNA folded in stable tridimensional folding are interesting targets in the development of antitumor or antiviral drugs. In the case of HIV-1, viral proteins involved in the regulation of the virus activity recognize several nucleic acids The ...
SOSIC, ALICE, Matteo Scalabrin, Marta Cappellini, GATTO, BARBARA   +3 more
core   +1 more source

Spike specific IgG3 and nucleocapsid IgG response in serum serve as distinguishing immunological markers between SARS-CoV-2 infection and vaccination

Frontiers in Immunology
BackgroundBoth SARS-CoV-2 infection and COVID-19 vaccines elicit immunological responses. However, it is difficult to distinguish responses generated after vaccination versus natural infection.MethodsWe investigated SARS-CoV-2 spike receptor-binding ...
Marjahan Akhtar, Md. Rashedul Islam, Fatema Khaton, Fatima Rahman, Tausif Adnan Sami, Imam Tauheed, Tasnuva Ahmed, Afroza Akter, Ishtiakul Islam Khan, Zahid Hasan Khan, Prasanta Kumar Biswas, Edward T. Ryan, Edward T. Ryan, Edward T. Ryan, Sayera Banu, Tahmina Shirin, Fahima Chowdhury, Ashraful Islam Khan, Taufiqur Rahman Bhuiyan, Firdausi Qadri   +19 more
doaj   +1 more source

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

HIV-1 Protease and Reverse Transcriptase Control the Architecture of Their Nucleocapsid Partner

, 2014
HIV-1 Protease and Reverse Transcriptase Control the Architecture of Their Nucleocapsid ...
PLOS ONE (2189197)
core   +1 more source

Genome‐scale evidence for host‐associated lineage divergence in the parasitoid, Microctonus aethiopoides

Insect Molecular Biology, EarlyView.
Host associations are primary drivers of genomic divergence, with clear phylogenetic separation observed between strains associated with Hypera and Sitona weevil hosts. Genomic diversity aligns with reproductive modes: sexually reproducing ancestral lineages maintain high heterozygosity, while derived asexual strains exhibit reduced heterozygosity and ...
Meeran Hussain, Elahe Parvizi, Mark R. McNeill, Angela McGaughran   +3 more
wiley   +1 more source

Rice Orange Leaf Phytoplasma Imp Protein Blocks G–M Interaction by Binding Glycoprotein G to Suppress Rice Stripe Mosaic Virus Infection

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants frequently encounter multiple pathogens concurrently, yet the molecular bases of pathogen–pathogen interactions during mixed infections remain largely unresolved. Here we show that co‐infection of rice by Rice orange leaf phytoplasma (ROLP) and Rice stripe mosaic virus (RSMV) markedly suppresses RSMV proliferation in both host plants ...
Jiaxin Qiu, Yujiao Zheng, Yanmei Yi, Yuxin Zhang, Tianbao Zeng, Hongyan Chen, Taiyun Wei, Xiao‐Feng Zhang   +7 more
wiley   +1 more source