Results 121 to 130 of about 79,219 (253)

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Extracellular vesicles containing SARS‐CoV‐2 proteins are associated with multi‐organ dysfunction and worse outcomes in patients with severe COVID‐19

Journal of Extracellular Vesicles
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus disease 2019 (COVID‐19) and has been related to more than 7 million deaths globally since 2019.
Diego deMiguel‐Perez, Marisol Arroyo‐Hernandez, Sabrina La Salvia, Muthukumar Gunasekaran, Edward M. Pickering, Stephanie Avila, Etse Gebru, Eduardo Becerril‐Vargas, Sergio Monraz‐Perez, Kapil Saharia, Alison Grazioli, Michael T. McCurdy, Matthew Frieman, Lisa Miorin, Alessandro Russo, Andrés F. Cardona, Adolfo García‐Sastre, Sunjay Kaushal, Fred R. Hirsch, Djordje Atanackovic, Susmita Sahoo, Oscar Arrieta, Christian Rolfo   +22 more
doaj   +1 more source

Bovine Herpesvirus Type 4 (BoHV-4) Vector Delivering Nucleocapsid Protein of Crimean-Congo Hemorrhagic Fever Virus Induces Comparable Protective Immunity against Lethal Challenge in IFNα/β/γR−/− Mice Models

Viruses, 2019
Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of a tick-borne infection with a significant mortality rate of up to 40% in endemic areas, with evidence of geographical expansion.
Touraj Aligholipour Farzani, Katalin Földes, Alireza Hanifehnezhad, Burcu Yener Ilce, Seval Bilge Dagalp, Neda Amirzadeh Khiabani, Koray Ergünay, Feray Alkan, Taner Karaoglu, Hurrem Bodur, Aykut Ozkul   +10 more
doaj   +1 more source

Two‐Dimensional Materials For Lateral Flow Assays: A Critical Review of Functional Roles and Translational Challenges

VIEW, EarlyView.
2D nanosheets, with large surface area, excellent optical/electrical properties, and high specificity, combine with lateral flow assay strips to enable rapid, readable detection, boosting the strips’ development and applications. Abstract Lateral flow assays (LFAs) are widely used for point‐of‐care diagnostics, but their detection capability remains ...
Weimin Xu, Ruping Liu, Na Gao, Jianxiao Zhu, Haowen Jiang, Shouzheng Jiao, Zhicheng Sun, Kai Shen, Gaolian Xu, Minghua Du, Ziyan Li, Yang Wang   +11 more
wiley   +1 more source

Structure-Function Relationships of the Nucleocapsid in Vesicular Stomatitis Virus [PDF]

, 2018
Understanding the basic structure-function relationships that guide the biology of various pathogenic viruses is the cornerstone in the development of antiviral therapies.
Gumpper, Ryan
core   +1 more source

ANDV nucleocapsid protein inhibits caspase 3-activity. [PDF]

, 2013
Analysis of possible interactions between ANDV nucleocapsid protein and caspase 3. (A) Western blot analyses showing a cleaved fragment of the ANDV nucleocapsid protein (ANDV-N) after incubation with recombinant caspase 3 in the presence or absence of ...
Karin B. Sundström (337165), Nicole D. Tischler (395814), Shawon Gupta (395812), Monika Braun (395813), Jonas Klingström (45509), Malin Stoltz (337164), Niklas K. Björkström (339612), Hans-Gustaf Ljunggren (189410)   +7 more
core   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Co-Delivery Effect of CD24 on the Immunogenicity and Lethal Challenge Protection of a DNA Vector Expressing Nucleocapsid Protein of Crimean Congo Hemorrhagic Fever Virus

Viruses, 2019
Crimean Congo hemorrhagic fever virus (CCHFV) is the causative agent of a globally-spread tick-borne zoonotic infection, with an eminent risk of fatal human disease.
Touraj Aligholipour Farzani, Alireza Hanifehnezhad, Katalin Földes, Koray Ergünay, Erkan Yilmaz, Hiba Hashim Mohamed Ali, Aykut Ozkul   +6 more
doaj   +1 more source

Strategies for enhancing sensitivity in lateral flow assays

VIEW, EarlyView.
Lateral flow assays (LFAs) are essential for cost‐effective, rapid point‐of‐care diagnostics. However, conventional colourimetric LFAs often lack the sensitivity required for low‐abundance biomarkers. This review evaluates six enhancement strategies: flow modulation, sample preconcentration, advanced reporters, chemical signal amplification, structural
Aylar Eslami Saed, Jacopo Giaretta, Syamak Farajikhah, Fariba Dehghani   +3 more
wiley   +1 more source

The coronavirus nucleocapsid protein is ADP-ribosylated

Virology, 2018
ADP-ribosylation is a common post-translational modification, although how it modulates RNA virus infection is not well understood. While screening for ADP-ribosylated proteins during coronavirus (CoV) infection, we detected a ~55kDa ADP-ribosylated protein in mouse hepatitis virus (MHV)-infected cells and in virions, which we identified as the viral ...
Grunewald, Matthew E., Fehr, Anthony R., Athmer, Jeremiah, Perlman, Stanley   +3 more
openaire   +2 more sources