Results 141 to 150 of about 79,219 (253)

Writing Big in Plant Genomes: Advances, Challenges and Strategies for Targeted Large‐Fragment DNA Insertion

Plant, Cell &Environment, EarlyView.
ABSTRACT Precise genome editing has transformed plant biology and crop improvement by enabling targeted modification of endogenous loci. Beyond gene knockout and base editing, the site‐specific insertion of exogenous DNA, particularly large DNA fragments, has become a central goal for engineering complex traits, reconstructing metabolic pathways and ...
Fengfeng Zhang, Daqi Yan, Jiayi Hou, Dan Yang, Yan Xiong, Mingzhang Wen, Xiaoyue Zhu   +6 more
wiley   +1 more source

Kidney Transplant Recipients Develop Nasal Mucosal Antibodies to SARS‐CoV‐2 With ACE2‐Inhibiting Activity Following mRNA Vaccination

Transplant Infectious Disease, EarlyView.
Kidney transplant recipients develop nasal mucosal antibodies after systemic COVID‐19 vaccination, which are able to inhibit binding of SARS‐CoV‐2 to the ACE2 receptor, but at a lower concentration than the general population. ABSTRACT Background Less than 60% of kidney transplant recipients (KTRs) become IgG seropositive for the viral spike (S ...
Vera J. C. H. Koomen, Christa E. van der Gaast‐deJongh, Fred van Opzeeland, Ria Philipsen, Marije C. Baas, A. Lianne Messchendorp, Frederike J. Bemelman, Marcia M. L. Kho, Carla C. Baan, Debbie van Baarle, Jan‐Stephan F. Sanders, Rob van Binnendijk, Gerco den Hartog, Ron T. Gansevoort, Renate G. van der Molen, Luuk B. Hilbrands, Dimitri A. Diavatopoulos   +16 more
wiley   +1 more source

Serodiagnosis of avian infectious bronchitis virus using recombinant nucleocapsid protein [PDF]

, 1996
Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the ...
Ndifuna, Abdul-El-Nuru
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Life Course Malaria Exposure and SARS‐CoV‐2 Seroepidemiology in Ugandan Adolescents: A Longitudinal Study Nested in a Birth Cohort

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background COVID‐19 has had major global health impacts, yet reported morbidity and mortality have been lower in Africa despite serological evidence of widespread infection. Malaria has been proposed as a potential modifier of susceptibility to and outcomes of SARS‐CoV‐2 infection.
Ludoviko Zirimenya, Doreen Nayebare, Claire Baine, Jacent Nassuuna, Milly Namutebi, Christopher Zziwa, Denis Nsubuga, Fred Kiwudhu, Florence Akello, Josephine Tumusiime, Gloria Oduru, Grace Kabami, Hellen Akurut, Rachel Nakyesige, Agnes Natukunda, Anne Wajja, Lawrence Lubyayi, Simon Kimuda, Gyaviira Nkurunungi, Jennifer Serwanga, Katie J. Doores, Emily L. Webb, Alison M. Elliott   +22 more
wiley   +1 more source

SARS-CoV-2 structural proteins affect the expression of IL-8 and TNF-α cytokines and APOBEC genes in human lung A549 and liver Huh-7 cells

Acta Pharmaceutica
The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of cytidine deami nases responsible for DNA and RNA sequence editing, playing pivotal roles in a wide range of biological processes, including immune ...
Marušič Martina Bergant, Costa Margarida, Turk Špela, Lovšin Nika   +3 more
doaj   +1 more source

Impact of delayed blood donation sample processing and testing on SARS‐CoV‐2 serological assay results in an evolving pandemic response

Transfusion, EarlyView.
Abstract Background The two largest US blood collection organizations led a multiphased, multicenter nationwide SARS‐CoV‐2 blood donor‐based serosurveillance program. The potential impact of delayed sample processing and prolonged refrigerated or frozen storage on anti‐SARS‐CoV‐2 antibody detection was investigated.
Marion C. Lanteri, Valerie Green, Hasan Sulaeman, Mars Stone, James Haynes, Clara Di Germanio, Sakina Smith, Patricia G. Villaflor, Jamel Groves, Phillip C. Williamson, Susan L. Stramer, Melissa M. Coughlin, Jefferson M. Jones, Eduard Grebe, Michael P. Busch, Paula Saa   +15 more
wiley   +1 more source

Hla-a*0201 T-Cell Epitopes in Severe Acute Respiratory Syndrome (Sars) Coronavirus Nucleocapsid and Spike Proteins [PDF]

, 2008
The immunogenicity of HLA-A*0201-restricted cytotoxic T lymphocyte (CTL) peptide in severe acute respiratory syndrome coronavirus (SARS-CoV) nuclear capsid (N) and spike (S) proteins was determined by testing the proteins' ability to elicit a specific ...
曹友平;詹家琮;陳小梨, TSAO, YEOU-PING;JAN, JIA-TSRONG;CHEN, SHOW-LI   +1 more
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Evaluation of Serum SARS-CoV-2 Nucleocapsid Antigen as a Diagnostic Tool in COVID-19 Patients [PDF]

COVID-19 has caused millions of casualties and deaths around the world. Countries all over the world exert great efforts to control the fast spread of the disease. Rapid diagnosis is a key tool in controlling the infection; therefore, numerous diagnostic
Mona H. Hashish, Amr A. Elsherif, Alaa K. Mahmoud, Marwa M. Fekry   +3 more
core   +2 more sources

Hepatitis B virus infection with high HBsAg and undetectable DNA levels in untreated blood donors: Viral mechanisms and transfusion safety implications

Transfusion, EarlyView.
Abstract Background Blood donor screening occasionally identifies individuals with high HBV surface antigen (HBsAg) levels despite undetectable or extremely low HBV DNA. Molecular basis and transfusion risk of this discordant profile remain unclear. Study Design and Methods Seventy‐five blood donors with HBsAg >100 IU/mL and undetectable or very low ...
Maelenn Païline Delcourt, Marion Vermeulen, Aneta Kopacz, Manuela Miletic, Andrew Saville, Christoph Niederhauser, Jean‐Michel Pawlotsky, Syria Laperche, Daniel Candotti   +8 more
wiley   +1 more source

Investigations into the mechanisms involved in baculovirus nucleocapsid egress [PDF]

, 2016
The mechanism of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) nucleocapsid egress from the nucleus to the plasma membrane leading to the formation of budded virus (BV) is not known.
Biswas, Siddhartha
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