Results 91 to 100 of about 48,033 (274)

Design of a recombinant asparaginyl ligase for site-specific modification using efficient recognition and nucleophile motifs

Communications Chemistry
Asparaginyl ligases have been extensively utilized as valuable tools for site-specific bioconjugation or surface-modification. However, the application is hindered by the laborious and poorly reproducible preparation processes, unstable activity and ...
Jiabao Tang, Mengling Hao, Junxian Liu, Yaling Chen, Gulimire Wufuer, Jie Zhu, Xuejie Zhang, Tingquan Zheng, Mujin Fang, Shiyin Zhang, Tingdong Li, Shengxiang Ge, Jun Zhang, Ningshao Xia   +13 more
doaj   +1 more source

Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence

eLife, 2016
Solar irradiation including ultraviolet (UV) light causes tissue damage by generating reactive free radicals that can be electrophilic or nucleophilic due to unpaired electrons.
Eun Jo Du, Tae Jung Ahn, Xianlan Wen, Dae-Won Seo, Duk L Na, Jae Young Kwon, Myunghwan Choi, Hyung-Wook Kim, Hana Cho, KyeongJin Kang   +9 more
doaj   +1 more source

Allylic Alkylation: Nature of the Nucleophile and Application to Prenylation

, 1978
Trost BM, Weber L, Strege PE, Fullerton TJ, Dietsche TJ. Allylic Alkylation: Nature of the Nucleophile and Application to Prenylation. Journal of the American Chemical Society.
Trost, Barry M., Fullerton, Terry J., Weber, Lothar, Strege, Paul E., Dietsche, Thomas J.   +4 more
core   +1 more source

Nucleophile Assistance of Electron-Transfer Reactions between Nitrogen Dioxide and Chlorine Dioxide Concurrent with the Nitrogen Dioxide Disproportionation

, 2016
The reaction of chlorine dioxide with excess NO2- to form ClO2- and NO3- in the presence of a large concentration of ClO2- is followed via stopped-flow spectroscopy.
Dale W. Margerum (2451712), Robert H. Becker (2965554), Jeffrey S. Nicoson (2346727)   +2 more
core   +2 more sources

Synthesis of Indole Derivatives via Aryl Triazole Ring-Opening and Subsequent Cyclization

Molecules
A metal-free two-step synthetic approach for obtaining indole derivatives from aryl triazole fragment-containing compounds has been developed. In the first step, the Dimroth equilibrium, followed by nitrogen extrusion, Wolff rearrangement, and amine ...
Aleksejs Burcevs, Armands Sebris, Irina Novosjolova, Anatoly Mishnev, Māris Turks   +4 more
doaj   +1 more source

Phosphazene-catalyzed desymmetrization of cyclohexadienones by dithiane addition

Beilstein Journal of Organic Chemistry, 2017
We report a desymmetrization of cyclohexadienones by intramolecular conjugate addition of a tethered dithiane nucleophile. Mild reaction conditions allow the formation of diversely functionalized fused bicyclic lactones.
Matthew A. Horwitz, Elisabetta Massolo, Jeffrey S. Johnson   +2 more
doaj   +1 more source

Nickel-Catalyzed Benzylic Substitution of Benzyl Esters with Malonates as a Soft Carbon Nucleophile

, 2019
The nickel-catalyzed benzylic substitution of benzyl alcohol derivatives with a soft carbon nucleophile is extremely rare compared to that with a hard carbon nucleophile.
Motoi Kawatsura (1814782), Hiroaki Tsuji (631376), Keisuke Hashimoto (2974434)   +2 more
core   +1 more source

Proton‐Induced Perthionitrite‐Mediated Zinc Thiolate Persulfidation

Angewandte Chemie, EarlyView.
A thiolate‐supported zinc thionitrite complex reacts with S8 to insert sulfur at both Zn–S bonds. Although SNO− persulfidation to SSNO− is facile, thiolate persulfidation is less favored in comparison. These thermodynamic differences between S–S‐containing moieties are also observed for free perthiolate and SSNO− anions.
Madeline N. Riffel, Oluwafemi O. Ishola, Allen G. Oliver, Emily Y. Tsui   +3 more
wiley   +2 more sources

Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence

Nature Communications, 2019
Catalytic asymmetric dearomatization (CADA) reactions readily convert common aromatic compounds to diverse 3D chiral, polycyclic molecules. Here, the authors report an intermolecular asymmetric dearomatization of nucleophile-tethered α-naphthols ...
Zi-Lei Xia, Chao Zheng, Ren-Qi Xu, Shu-Li You   +3 more
doaj   +1 more source

nucleophilicity

, 2014
Citation: 'nucleophilicity' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.N04251 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source