Results 71 to 80 of about 48,033 (274)
‐Oxides Enabled by a Traceless Nucleophile
, 2020 Although N-alkenoxyheteroarenium salts have been widely used as umpoled synthons with nucleophilic (hetero)arenes, the use of electron-poor heteroarenes has remained unexplored.
Sungwoo Hong +9 more
core +1 more source
Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont
Angewandte Chemie, EarlyView.Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley +11 more
wiley +2 more sources
Switching ATP‐Forming Phosphoryl‐Transfer Chemistry With a Restricted Set of Amino Acids
Angewandte Chemie, EarlyView.Constraints on amino acid composition relevant to prebiotic chemistry reshape enzyme chemistry by replacing the canonical mechanism within a conserved protein fold with a distinct ATP‐forming reaction, ADP disproportionation. Such constraints generate alternative catalytic solutions not observed in modern enzymes and point to chemically plausible early
Sota Yagi +3 more
wiley +2 more sources
Organic Diselenides: Versatile Reagents, Precursors, and Intriguing Biologically Active Compounds
CHIMIA, 2017 In this account, we describe how some organic diselenides were successfully used in the past as reagents for asymmetric stereoselective synthesis and more recently as precursors of catalysts and reagents applied in new green protocols.
Claudio Santi +2 more
doaj +1 more source
Controllable intein splicing and N-terminal cleavage at mesophilic temperatures
Frontiers in Bioengineering and BiotechnologyInteins (intervening proteins) interrupt host proteins and are removed through a protein splicing reaction that ligates adjacent N- and C-exteins. The ability of inteins to specifically rearrange peptide bonds has proven exceptionally useful in protein ...
Taylor A. McNeal +6 more
doaj +1 more source
A gold-catalyzed, nucleophile-controlled cascade reaction of N-(2-azidophenyl-ynyl)methanesulfonamides with nitriles and water is described that provides structurally diverse 5H-pyrimido[5,4-b]indoles and 2-benzylidene-3-indolinones in good to excellent ...
Yun-Long Zhu (11282472) +5 more
core +1 more source
Angewandte Chemie, EarlyView.A Keplerate, an inorganic, porous buckyball was used as a host for copper metal cations ligated by histidine surrogates. Prepared by a simple assembly technique, the guest–host complex was used as a primitive biomimetic model of a monooxygenase enzyme complex, where C─H bonds were electrocatalytically hydroxylated by oxygen under reducing conditions ...
Eynat Haviv +4 more
wiley +2 more sources
A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme
Nature CommunicationsDirected evolution of computationally designed enzymes has provided new insights into the emergence of sophisticated catalytic sites in proteins. In this regard, we have recently shown that a histidine nucleophile and a flexible arginine can work in ...
Amy E. Hutton +10 more
doaj +1 more source
Molecules, 2020 In this study, we present a complete description of the addition of a model nucleophile to the nitroaromatic ring in positions occupied either by hydrogen (the first step of the SNAr-H reaction) or a leaving group (SNAr-X reaction) using theoretical ...
Kacper Błaziak +2 more
doaj +1 more source
A novel Pd-catalysed sequential carbonylation/cyclization approach toward bis-N-heterocycles: rationalization by electronic structure calculations [PDF]
Royal Society Open Science, 2018 An unprecedented palladium-catalysed sequential aminocarbonylation/cyclization synthetic strategy, using carbon monoxide and structurally different aliphatic diamines as N-nucleophiles, gives access, in one pot, to a new family of indole-based N ...
Liliana Damas +6 more
doaj +1 more source