Results 161 to 170 of about 23,876 (290)
Interactome mapping reveals the evolutionary history of the nuclear pore complex [PDF]
, 2016 The nuclear pore complex (NPC) is responsible for nucleocytoplasmic transport and constitutes a hub for control of gene expression. The components of NPCs from several eukaryotic lineages have been determined, but only the yeast and vertebrate NPCs have ...
Brillantes, Marc +7 more
core +5 more sources
HOXA repression is mediated by nucleoporin Nup93 assisted by its interactors Nup188 and Nup205
Epigenetics & Chromatin, 2016 BackgroundThe nuclear pore complex (NPC) mediates nuclear transport of RNA and proteins into and out of the nucleus. Certain nucleoporins have additional functions in chromatin organization and transcription regulation. Nup93 is a scaffold nucleoporin at
Ajay S. Labade +2 more
semanticscholar +1 more source
eLife, 2016 The nucleoporin Nup98 is frequently rearranged to form leukemogenic Nup98-fusion proteins with various partners. However, their function remains largely elusive. Here, we show that Nup98-HoxA9, a fusion between Nup98 and the homeobox transcription factor
Masahiro Oka +10 more
doaj +1 more source
Targeting self-renewal pathways in myeloid malignancies [PDF]
, 2013 A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core +2 more sources
Nucleoporins and Transcription: New Connections, New Questions
PLoS Genetics, 2010 It seems to make perfect sense that RNA, which must be exported from the nucleus to be translated, would be produced near or in association with nuclear pores. Indeed, recent reports proposed that Saccharomyces cerevisiae genes located close to the nuclear pore complex (NPC) tend to be highly transcribed [1],[2] and that, upon activation, some genes ...
Kohta Ikegami, Jason D Lieb
openaire +3 more sources
Frontiers in Plant Science, 2014 Mutations in the Lotus japonicus nucleoporin genes, NUP85, NUP133 and NENA (SEH1), lead to defects in plant-microbe symbiotic signaling. The homologous proteins in yeast and vertebrates are part of the conserved NUP84/NUP107-160 sub-complex, which is an ...
Andreas eBinder, Martin eParniske
doaj +1 more source
Toward the atomic structure of the nuclear pore complex: when top down meets bottom up [PDF]
, 2016 Elucidating the structure of the nuclear pore complex (NPC) is a prerequisite for understanding the molecular mechanism of nucleocytoplasmic transport.
Beck, Martina +2 more
core +1 more source
Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions
Science Advances, 2019 Kap121 interacts with an intrinsically disordered region of Nup53 to allosterically modulate Nup53 binding to partner nucleoporins. Intrinsically disordered regions (IDRs) of proteins are implicated in key macromolecular interactions.
B. J. Blus +5 more
semanticscholar +1 more source
Hydrogels: Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport (Adv. Mater. 28/2015) [PDF]
, 2015 Minkyu Kim +5 more
openalex +1 more source
Evolution of a transcriptional regulator from a transmembrane nucleoporin
Genes & Development, 2016 Franks et al. identify a widely expressed variant of the transmembrane nucleoporin Pom121 (named sPom121, for “soluble Pom121”) that arose by genomic rearrangement before the divergence of hominoids.
T. Franks +7 more
semanticscholar +1 more source