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A tool to pulse-label yeast Nuclear Pore Complexes in imaging and biochemical experiments
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Nucleoporins and chromatin metabolism
Current Opinion in Cell Biology, 2016Mounting evidence has implicated a group of proteins termed nucleoporins, or Nups, in various processes that regulate chromatin structure and function. Nups were first recognized as building blocks for nuclear pore complexes, but several members of this group of proteins also reside in the cytoplasm and within the nucleus.
Christopher, Ptak, Richard W, Wozniak
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Phosphorylation and Glycosylation of Nucleoporins
Archives of Biochemistry and Biophysics, 1999The nuclear pore complex mediates macromolecular transport between the nucleus and cytoplasm. Many nuclear pore components (nucleoporins) are modified by both phosphate and O-linked N-acetylglucosamine (O-GlcNAc). Among its many functions, protein phosphorylation plays essential roles in cell cycle progression. The role of O-GlcNAc addition is unknown.
M W, Miller +3 more
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From nucleoporins to nuclear pore complexes
Current Opinion in Cell Biology, 1997One of the largest supramolecular assemblies in the eukaryotic cell, the nuclear pore complex, is now being dissected into its numerous molecular constituents. The combined use of biochemistry and genetics in yeast has made this rapid development possible.
V, Doye, E, Hurt
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Nucleoporins and nucleocytoplasmic transport in hematologic malignancies
Seminars in Cancer Biology, 2014Hematologic malignancies are often associated with chromosomal rearrangements that lead to the expression of chimeric fusion proteins. Rearrangements of the genes encoding two nucleoporins, NUP98 and NUP214, have been implicated in the pathogenesis of several types of hematologic malignancies, particularly acute myeloid leukemia.
Akiko, Takeda, Nabeel R, Yaseen
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Nucleoporin-associated steroid-resistant nephrotic syndrome
Pediatric NephrologyNucleoporins (Nups) are a class of proteins that assemble to form nuclear pore complexes, which are related to nucleocytoplasmic transport, gene expression, and the cell cycle. Pathogenic variants in six genes encoding Nups, NUP85, NUP93, NUP107, NUP133, NUP160, and NUP205, cause monogenic steroid-resistant nephrotic syndrome (SRNS), referred to as ...
Ling Yao +4 more
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Exploring genotype-phenotype correlation in nucleoporin nephropathy
Pediatric ResearchNucleoporin nephropathy, a rare genetic kidney disorder, is not well-characterized despite its early onset in childhood.We analyzed the clinical and genetic data of pediatric patients diagnosed with nucleoporin nephropathy at a southern Chinese pediatric nephrology center, and reviewed global cases reported up until July 2024.In our center, five ...
Yuxin, Pei +5 more
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