Results 141 to 150 of about 15,615 (292)
Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma
Advanced Science, Volume 13, Issue 3, 14 January 2026.IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang +16 more
wiley +1 more source
Real-time measurements of the nucleation, growth and dissociation of single Rad51–DNA nucleoprotein filaments [PDF]
, 2007 Judith Miné +5 more
openalex +1 more source
Advanced Science, Volume 13, Issue 6, 30 January 2026.This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun +12 more
wiley +1 more source
Miscellaneous bean viruses [PDF]
, 2017 Bean crops are attacked by several viruses transmitted by insects among which are: (1) the alfalfa mosaic virus (aphids); susceptibility is correlated with plant age; (2) curly top (Circulifer tenellus); the best control measure is the utitilization of ...
Castaño, M.J., Gálvez E., Guillermo E.
core
Mapping of Antibody Epitopes on the Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein [PDF]
, 2022 Boniface Pongombo Lombe +9 more
openalex +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.MSC‐EVs alleviate peritoneal inflammation and fibrogenesis by disrupting the H3K18la‐CCL2 axis and crosstalk between mesothelial cells and Ly6c2⁺ macrophages. Model cartoons are constructed using the Biorender website (https://www.biorender.com/), and a usage license is obtained. Abstract Peritoneal dialysis (PD), as a renal replacement therapy, relies
Qiang Huang +12 more
wiley +1 more source
Nucleoproteins of Cell Nuclei [PDF]
Proceedings of the National Academy of Sciences, 1942 A E, Mirsky, A W, Pollister
openaire +2 more sources
Advanced Science, Volume 13, Issue 3, 14 January 2026.A cell‐mimetic hydrogel compartment is proposed to enhance the efficiency of enzymatic reactions. The naturally porous structure of a crowded hydrogel can simulate the intracellular microenvironment, promoting the aggregation of biomolecules and activity of DNA polymerase through excluded volume effects and compartmentalization.
Fangbin Xiao +3 more
wiley +1 more source
Environmental DNA, Volume 8, Issue 1, January–February 2026.VHSV and IHNV molecular detection in environmental samples was tested in controlled infection trials. We show that, in water, detected viral eRNA copies correlate with infectious particle numbers. After comparison of viral concentration methods from water, we demonstrate the feasibility of filter‐based eRNA detection in IHNV‐positive aquaculture farms.
Giulia Zarantonello +5 more
wiley +1 more source