Results 131 to 140 of about 15,441 (294)
Short and complex—Telomeres and genomes in CLL
Chronic lymphocytic leukaemia (CLL) with complex karyotype (CK) represents a high‐risk subgroup, often associated with refractory disease. In a patient cohort enriched for CK CLL, short telomeres were found to be associated with poor‐risk characteristics such as unmutated immunoglobulin heavy chain variable region (IGHV), del(11q)/del(17p), CK/genomic ...
Billy Michael Chelliah Jebaraj +1 more
wiley +1 more source
Since the specific capacity and tolerance of cells, including sperm proteins depend on their natural, it was necessary to study the protein fractions changes depending on the semen storage temperature.
USM ADMIN
doaj
Macromolecular 4-aminoquinoline compounds as potential antimalarial drugs [PDF]
4-Aminoquinolines have a long and successful history as antimalarials as they have provided a number of useful antimalarials. P. falciparum, a causative organism of the most deadly form of human malaria, is generally slow to develop resistance to these ...
Aderibigbe, Atim Blessing
core
Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition
Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis +9 more
wiley +1 more source
The regulatory subunit RIβ of protein kinase A occurs in two variants that differ at residue 268 (A268 versus R268). This seemingly small substitution significantly changes cAMP sensitivity, basal kinase activity, and the dynamic behavior of the regulatory domains.
Maximilian Wallbott +6 more
wiley +1 more source
Nucleoprotein and membrane protein genes are associated with restriction of replication of influenza A/Mallard/NY/78 virus and its reassortants in squirrel monkey respiratory tract [PDF]
S F Tian +5 more
openalex +1 more source
Potential antiviral peptides against the nucleoprotein of SARS-CoV-2
Iktedar Mahdi +8 more
openalex +2 more sources
Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos +4 more
wiley +1 more source
3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut +2 more
wiley +1 more source

