Results 131 to 140 of about 15,441 (294)

Short and complex—Telomeres and genomes in CLL

open access: yesBritish Journal of Haematology, Volume 208, Issue 4, Page 1503-1504, April 2026.
Chronic lymphocytic leukaemia (CLL) with complex karyotype (CK) represents a high‐risk subgroup, often associated with refractory disease. In a patient cohort enriched for CK CLL, short telomeres were found to be associated with poor‐risk characteristics such as unmutated immunoglobulin heavy chain variable region (IGHV), del(11q)/del(17p), CK/genomic ...
Billy Michael Chelliah Jebaraj   +1 more
wiley   +1 more source

DINAMICA SPECTRULUI FRACŢIILOR PROTEICE ALE MATERIALULUI SEMINAL UMAN SUB INFLUENŢA STRESĂRII HIPO-HIPERTERMICE

open access: yesStudia Universitatis Moldaviae: Stiinte reale si ale naturii, 2010
Since the specific capacity and tolerance of cells, including sperm proteins depend on their natural, it was necessary to study the protein fractions changes depending on the semen storage temperature.
USM ADMIN
doaj  

Macromolecular 4-aminoquinoline compounds as potential antimalarial drugs [PDF]

open access: yes, 2011
4-Aminoquinolines have a long and successful history as antimalarials as they have provided a number of useful antimalarials. P. falciparum, a causative organism of the most deadly form of human malaria, is generally slow to develop resistance to these ...
Aderibigbe, Atim Blessing
core  

Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition

open access: yesThe FEBS Journal, Volume 293, Issue 7, Page 2119-2132, April 2026.
Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis   +9 more
wiley   +1 more source

Functional divergence of protein kinase A regulatory subunit Iβ variants: the importance of N3A motifs in PKA regulation

open access: yesThe FEBS Journal, Volume 293, Issue 8, Page 2417-2434, April 2026.
The regulatory subunit RIβ of protein kinase A occurs in two variants that differ at residue 268 (A268 versus R268). This seemingly small substitution significantly changes cAMP sensitivity, basal kinase activity, and the dynamic behavior of the regulatory domains.
Maximilian Wallbott   +6 more
wiley   +1 more source

Potential antiviral peptides against the nucleoprotein of SARS-CoV-2

open access: green, 2022
Iktedar Mahdi   +8 more
openalex   +2 more sources

MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria

open access: yesThe FEBS Journal, Volume 293, Issue 7, Page 2086-2097, April 2026.
Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos   +4 more
wiley   +1 more source

3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes

open access: yesThe FEBS Journal, Volume 293, Issue 8, Page 2500-2513, April 2026.
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut   +2 more
wiley   +1 more source

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