Results 141 to 150 of about 25,304 (272)

Nonlinearities and Switch‐Like Behavior in Gene Expression: From Genetics to Biochemistry and Back

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Modest changes in transcription‐factor or chromatin‐regulator dosage can have disproportionate effects when gene‐regulatory systems operate near nonlinear thresholds. Sigmoidal input–output relationships, chromatin and cofactor recruitment, and changes in threshold position or response steepness provide molecular routes by which quantitative dosage ...
Reiner A. Veitia, James A. Birchler
wiley   +1 more source

Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere.

Genome Research, 2007
L. Wong, K. Brettingham-Moore, Lyn Chan, J. Quach, Melissa A. Anderson, Emma L. Northrop, R. Hannan, R. Saffery, Margaret L. Shaw, Evan J. Williams, K. H. Andy Choo   +10 more
semanticscholar   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Localization to the Nucleolus Is a Common Feature of Coronavirus Nucleoproteins, and the Protein May Disrupt Host Cell Division

Journal of Virology, 2001
T. Wurm, Hong-Ying Chen, Teri Hodgson, P. Britton, G. Brooks, J. Hiscox   +5 more
semanticscholar   +1 more source

From Nucleobases to Bioactive NHC‐Based Gold and Silver Complexes With Anticancer and Antiviral Activity

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Herein, we reported the design and synthesis of a novel series of N‐heterocyclic carbene (NHC) complexes originated from the imidazole ring of guanine and guanosine and with different counterions (iodide, acetate, and aminoacidate). The evaluation of the biological activities, that is anticancer and antiviral, indicated L2AuOAc as the best complex ...
Domenico Iacopetta, Jessica Ceramella, Paola Checconi, Flavio Frezza, Maria Marra, Annaluisa Mariconda, Assunta D’Amato, Alessia Catalano, Stefano Aquaro, Pasquale Longo, Maria Stefania Sinicropi   +10 more
wiley   +1 more source

Structural Prediction and Antigenic Characterization of Recombinant Nucleocapsid Protein (p14) of Small Ruminant Lentivirus. [PDF]

Viruses
Castañeda-Montes MA, Cerriteño-Sánchez JL, Cuevas-Romero JS, Castañeda-Montes FJ, González-Esparragoza D, Ávila-De la Vega LM, Ramírez-Álvarez H.   +6 more
europepmc   +1 more source

The fission of tobacco mosaic virus and some other nucleoproteins by strontium nitrate [PDF]

, 1954
Pirie, N. W.
core   +1 more source

Endosomal maturation leads to nucleocapsid conformation change in seasonal coronaviruses. [PDF]

Nagoya J Med Sci
Umeda M, Yoshimura K, Sato Y, Miyake Y, Kimura H.   +4 more
europepmc   +1 more source

STUDIES ON NUCLEOPROTEINS

Journal of Biological Chemistry, 1954
Charles F. Crampton, Rakoma Lipshitz, Erwin Chargaff   +2 more
openaire   +1 more source

Solution Structure of Nucleoprotein Domain 1 from the Emerging Yezo Virus. [PDF]

Int J Mol Sci
Gladysheva AV, Yanshin AO, Radchenko NS, Osinkina IA, Ukladov EO, Agafonov AP.   +5 more
europepmc   +1 more source