Results 131 to 140 of about 174,887 (292)

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters

The Journal of Clinical Pharmacology, EarlyView.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Nancy Agrawal, Janet Hammond   +9 more
wiley   +1 more source

Contribution of Nucleoside-Analogue Reverse Transcriptase Inhibitor Therapy to Lipoatrophy from the Population to the Cellular Level [PDF]

, 2003
David Nolan, E. Hammond, Ian James, E. McKinnon, S. Mallal   +4 more
openalex   +1 more source

Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases

, 2021
Petra Břehová, Ema Chaloupecká, Michal Česnek, Jan Skácel, Martin Dračínský, Eva Tloušťová, Helena Mertlíková‐Kaiserová, Monica Soto‐Velasquez, Val J. Watts, Zlatko Janeba   +9 more
openalex   +2 more sources

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Indolylarylsulfones Bearing Natural and Unnatural Amino Acids. Discovery of Potent Inhibitors of HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase and Coxsackie B4 Virus

, 2009
Francesco Piscitelli, Antonio Coluccia, Andrea Brancale, Giuseppe La Regina, Anna Sansone, Cesare Giordano, Jan Balzarini, Giovanni Maga, Samantha Zanoli, Alberta Samuele, Roberto Cirilli, Francesco La Torre, Antonio Lavecchia, Ettore Novellino, Romano Silvestri   +14 more
openalex   +1 more source

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source

Prodrug strategies in developing antiviral nucleoside analogs. [PDF]

RSC Med Chem
Suresh RR, Abuduani T, Kasthuri M, Chen Z, Tber Z, Loubidi M, Zhang H, Zhou L, Zhou S, Li C, Kumari A, Tao S, Wiseman JM, Hurwitz SJ, Amblard F, Schinazi RF.   +15 more
europepmc   +1 more source

Recurrent Respiratory Papillomatosis Foundation Position Statement on the Management of Adults With RRP

The Laryngoscope, EarlyView.
ABSTRACT Objective With regulatory approval of HPV‐specific immunotherapy for recurrent respiratory papillomatosis (RRP) and growing experience with systemic bevacizumab, a management algorithm incorporating these medical treatments is warranted. Data Sources and Methods RRP Foundation (RRPF) Key Opinion Leaders offer a proposed management algorithm ...
Simon R. Best, Aaron D. Friedman, Clark A. Rosen, Robert T. Sataloff, Laura A. Matrka, H. Steven Sims, David E. Rosow, Nabil F. Saba, David G. Lott, Adam M. Klein, Ted Mau, Milan R. Amin, Kathryn A. Wikenheiser‐Brokamp, Scott M. Norberg, Kim McClellan, Geoffrey D. Young, Clint T. Allen, on behalf of the Recurrent Respiratory Papillomatosis Foundation   +17 more
wiley   +1 more source

Nutrition Status of Trees on Spoil Heaps After Coal Mining Can Be Inferred From Seasonal Dynamics of Foliar Nutrient Concentrations

Land Degradation &Development, EarlyView.
ABSTRACT A stable vegetation cover on given habitat conditions can be one of the possible requirements for post‐mining sites, as it can prevent erosion and dustiness of these anthropogenic surfaces and bring several practical future benefits, such as biomass production and microclimate improvement.
Tomáš Matys Grygar, Michaela Königová, Slavomír Adamec, Gabriela Bílková, Petr Vorm, Věra Hýlová   +5 more
wiley   +1 more source

HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with virological failure to nucleoside drug combinations [PDF]

, 2009
César Garriga, Maria Jesús Pérez‐Elías, Rafaël Delgado, Lı́dia Ruiz, Lucía Pérez-Álvarez, Tomàs Pumarola, A. López-Lirola, Juan González‐García, Luis Menéndez‐Arias   +8 more
openalex   +1 more source