Results 161 to 170 of about 174,887 (292)

Inhibition of Siderophore Biosynthesis by 2-Triazole Substituted Analogues of 5′-O-[N-(Salicyl)sulfamoyl]adenosine: Antibacterial Nucleosides Effective against Mycobacterium tuberculosis

, 2008
Amol Gupte, Helena I. Boshoff, Daniel J. Wilson, João Neres, Nicholas P. Labello, Ravindranadh V. Somu, Chengguo Xing, Clifton E. Barry, Courtney C. Aldrich   +8 more
openalex   +2 more sources

Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley   +1 more source

Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors. [PDF]

Nat Commun
Meng Q, Benckendorff C, Morrill C, Zhuo Y, Egerström A, Ní Cheallaigh A, Derrington SR, Obexer R, Ortmayer M, Levy CW, Finnigan JD, Charnock SJ, Turner NJ, Miller GJ, Lovelock SL.   +14 more
europepmc   +1 more source

Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays

, 2009
Lyn H. Jones, Gill Allan, Oscar Barba, Catherine Burt, Romuald Corbau, Thomas Dupont, Thorsten Knöchel, Steve Irving, Donald S. Middleton, Charles E. Mowbray, Manos Perros, H. Ringrose, Nigel A. Swain, Robert O. Webster, Mike Westby, Chris Phillips   +15 more
openalex   +1 more source

Biosynthesis of the β-Methylarginine Residue of Peptidyl Nucleoside Arginomycin in Streptomyces arginensis NRRL 15941 [PDF]

, 2014
Jun Feng, Jun Wu, Jie Gao, Zhigui Xia, Zixin Deng, Xinyi He   +5 more
openalex   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Recognition of unnatural base pairs by a eukaryotic DNA polymerase enables universal sequencing of an expanded genetic alphabet. [PDF]

Nucleic Acids Res
Luo H, Du Y, Sun L, Ye F, Ma J, Wang X, Wang Y, Chen T.   +7 more
europepmc   +1 more source

Purine nucleoside analogs: emerging roles in indolent lymphoproliferative disorders [published erratum appears in Blood 1996 Mar 1;87(5):2093] [PDF]

, 1995
MS Tallman, D Hakimian
openalex   +1 more source

Exploring the Fragmentation of Sodiated Species Involving Covalent‐Bond Cleavages for Metabolite Characterization

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Electrospray (ESI), the most popular desorption/ionization technique used in mass spectrometry‐based metabolomics, generates both protonated and deprotonated molecules, as well as adduct ions, sodium being the most frequent monoatomic cation entering their composition.
Annelaure Damont, Ekaterina Darii, Chenqin Cao, Anaïs Legrand, Alain Perret, Sylvain Dechaumet, Amina S. Woods, Christophe Junot, Jean‐Claude Tabet, François Fenaille   +9 more
wiley   +1 more source

Improved Nucleoside (2'-Deoxy)Ribosyltransferases Maximize Enzyme Promiscuity while Maintaining Catalytic Efficiency. [PDF]

ACS Chem Biol
Tang P, Zickuhr GM, Dickson AL, Harding CJ, Devi S, Lebl T, Harrison DJ, da Silva RG, Czekster CM.   +8 more
europepmc   +1 more source