Results 161 to 170 of about 146,762 (298)

BASIS OF ACTINOMYCIN ACTION, II. EFFECT OF ACTINOMYCIN ON THE NUCLEOSIDE TRIPHOSPHATE-INORGANIC PYROPHOSPHATE EXCHANGE

, 1963
I. Goldberg, Murray Rabinowitz, E. Reich
openalex   +1 more source

Comprehensive Multi‐Omics Integration Reveals B Cell‐Derived ELL2 as a Novel Diagnostic and Prognostic Biomarker in Sepsis

Med Research, EarlyView.
We analyzed bulk transcriptome sequencing data from 10 cohorts of sepsis patients. Using unbiased patient clustering, we identified three subtypes with significantly different prognoses, which were consistently reproduced across all 10 cohorts. Through comprehensive multi‐angle analyses, we revealed distinct differences among the subtypes in terms of ...
Xuan Wang, Jihong Li, Jingyuan Ning
wiley   +1 more source

Pharmacokinetics and Metabolism of Broad-Spectrum Antivirals Remdesivir and Obeldesivir with a Consideration to Metabolite GS-441524: Same, Similar, or Different? [PDF]

Viruses
Babusis D, Kim C, Yang J, Zhao X, Geng G, Ip C, Kozon N, Le H, Leung J, Pitts J, Siegel DS, Kalla R, Murray B, Bilello JP, Bannister R, Mackman RL, Subramanian R.   +16 more
europepmc   +1 more source

A Mathematical Model for Allergic Reactions Induced by the Therapy of HIV

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT A new mathematical model for cell evolution in HIV is introduced and studied. Delay differential equations are used to capture the dynamics of immune system cells involved in allergies, as well as the evolution of HIV viruses, infected and uninfected CD4+$$ {}^{+} $$ cells, and cytotoxic T‐lymphocytes, under specific antiretroviral therapy ...
Rawan Abdullah, Florin Avram, Andrei Halanay, Rodica Radulescu   +3 more
wiley   +1 more source

3'-<i>O</i>-β-Glucosylation of nucleoside analogues using a promiscuous bacterial glycosyltransferase. [PDF]

RSC Chem Biol
Dolan JP, Keenan T, Cheallaigh AN, Fascione MA, Miller GJ.   +4 more
europepmc   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

The Electronic Properties of Cordycepin in the Adenine Nucleoside Landscape: A Theoretical Approach. [PDF]

Molecules
Karwowski BT.
europepmc   +1 more source

Studies on Nucleosides and Nucleotides. IX. Nucleophilic Substitution of Secondary Sulfonyloxy Groups of Pyrimidine Nucleosides. II. Reaction of 2, 2'-Anhydro-1-(3'-O-tosyl-β-D-arabinofuranosyl) uracil with Sodium Bromide, Sodium Ethanethiol, and Sodium Azide

, 1968
Miyoshi Hirata
openalex   +2 more sources

Nucleosides. XLIX. Nuclear magnetic resonance studies of 2′-and 3′-halogeno nucleosides. The conformations of 2′-deoxy-2′-fluorouridine and 3′-deoxy-3′-fluoro-β-D-arabinofuranosyluracil [PDF]

, 1968
Robert J. Cushley, John F. Codington, Jack J. Fox   +2 more
openalex   +1 more source

Thiostrepton Suppresses the Progression of Rhabdomyosarcoma by Inhibiting the PI3K‐AKT Signaling Pathway

Pediatric Discovery, EarlyView.
The study establish TST as a multi‐mechanism PI3K‐AKT inhibitor for refractory RMS while validating Cmap‐driven drug repurposing for pediatric oncology. ABSTRACT Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma with 5‐year survival below 30% in high‐risk/metastatic cases, was investigated through integrated bioinformatics analysis (
Yu Wang, Peng Hong, Zhiqiang Gao, Wei Ma, Zaihong Hu, Jie Lin, Kongkong Cui, Qinlin Shi, Xiao‐Mao Tian, Guanghui Wei   +9 more
wiley   +1 more source