Results 201 to 210 of about 171,665 (294)

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Studies of Nucleosides and Nucleotides. XXXIX. Synthesis of 8-Substituted Purine Nucleotides by the Direct Replacement Reactions

, 1969
Morio Ikehara, Ichiro Tazawa, Toshikazu Fukui   +2 more
openalex   +2 more sources

Cell-selective telomere damage by thiopurine-based oligonucleotide for diffuse large B cell lymphoma immunotherapy. [PDF]

Mol Ther
Yu C, Kang EY, Wang D, Liang Y, Swiderski P, Feng Y, Li H, Synold T, Forman S, Kwak L, Kortylewski M.   +10 more
europepmc   +1 more source

A Population Pharmacokinetic Approach to Understand the Effect of Efavirenz on CYP3A Activity in Healthy Volunteers Using Midazolam as a Probe

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Efavirenz induces and inhibits multiple drug‐metabolizing enzymes, contributing to significant drug–drug interactions. This study quantified the impact of multiple doses of efavirenz on CYP3A activity via midazolam metabolism using a population pharmacokinetic approach.
Kimberly S. Collins, Blessed W. Aruldhas, Ingrid F. Metzger, Jessica B. L. Lu, Michael A. Heathman, Sara K. Quinney, Zeruesenay Desta   +6 more
wiley   +1 more source

The support of active potassium transport in human red cells by nucleosides and deoxynucleosides

, 1960
R. Whittam
openalex   +2 more sources

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

A scope of prebiotic neat reaction conditions and the mechanism of urea-assisted phosphorylations of alcohols. [PDF]

Nat Commun
Shvetsova A, Merzoud L, Lopez A, Fromentin E, Baudouin A, Chermette H, Daniel I, Fiore M, Strazewski P.   +8 more
europepmc   +1 more source

Exploring the Fragmentation of Sodiated Species Involving Covalent‐Bond Cleavages for Metabolite Characterization

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Electrospray (ESI), the most popular desorption/ionization technique used in mass spectrometry‐based metabolomics, generates both protonated and deprotonated molecules, as well as adduct ions, sodium being the most frequent monoatomic cation entering their composition.
Annelaure Damont, Ekaterina Darii, Chenqin Cao, Anaïs Legrand, Alain Perret, Sylvain Dechaumet, Amina S. Woods, Christophe Junot, Jean‐Claude Tabet, François Fenaille   +9 more
wiley   +1 more source

Studies on Nucleosides and Nucleotides. VII-VIII. VIII. A N ew Method for Synthesis of Purine-Ribonucleosides, . Part. 2

, 1960
Tetsuo Sato, Tosisada SIMADATE, Yoshiharu Ishido   +2 more
openalex   +2 more sources

Experimental and computational approaches for evaluating molecule interactions with equilibrative nucleoside transporters 1 and 2. [PDF]

J Pharmacol Exp Ther
Martinez-Guerrero LJ, Vignaux PA, Farrera DO, Harris JS, Raman R, Lane TR, Wright SH, Ekins S, Cherrington NJ.   +8 more
europepmc   +1 more source