Results 201 to 210 of about 146,762 (298)

Studies on Synthetic Nucleosides, II. Novel Synthesis of Pyrimidine Glucosides.

, 1964
Takuzo Nishimura, Issei Iwai
openalex   +2 more sources

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, EarlyView.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Mediated Electrochemical Oxidation of Nucleosides to Their 5'-Carboxylic Acid Derivatives. [PDF]

Chemistry
Abrams DJ, Johnson MR, Lacker CR, Yoon TP, Martinelli JR, Stahl SS.   +5 more
europepmc   +1 more source

Studies of Nucleosides and Nucleotides. XXIII. A Versatile Method for Replacement of 6-Hydroxyl Group of Purine Nucleoside.

, 1964
Morio Ikehara, Hitoshi Uno, Fumiyoshi Ishikawa   +2 more
openalex   +2 more sources

Clinical Utility and Cost‐Effectiveness of Pretreatment NUDT15 Pharmacogenetic Testing to Prevent Thiopurine‐Induced Myelosuppression: A Genotype‐First Reverse Phenotyping Cohort Study Within the UK NIHR Inflammatory Bowel Disease Bioresource

Alimentary Pharmacology &Therapeutics, EarlyView.
Carriage of any loss of function NUDT15 varaint is associated with an increased risk of thiopurine‐induced myelosuppression. Pre‐treatment genotype testing of NUDT15. ABSTRACT Background The clinical utility and cost‐effectiveness of pre‐thiopurine NUDT15 pharmacogenetic testing in European and admixed populations are unknown.
Christopher Roberts, Jaime Peters, Aleksejs Sazonvos, Neil Goodman, Mohmmed Sharip, Rebecca Smith, Maria Bishara, Claire Bewshea, Simeng Lin, Neil Chanchlani, Phoebe Hodges, Fakhirah Badrulhisham, Aamir Saifuddin, Sean Carlson, Andrea Centritto, Alexandra Marley, Muhammad Saad, Karishma Sethi‐Aora, Laura White, Alaa Abdelmeguid, Laetitia Pele, Shaji Sebastian, Christian Selinger, Peter Irving, Laura Fachal, Gareth Walker, Rachel Palmer, Nick Kennedy, Jayne Houghton, Chris Hyde, Miles Parkes, James Goodhand, Tariq Ahmad   +32 more
wiley   +1 more source

On the Quest for Biomarkers: A Comprehensive Analysis of Modified Nucleosides in Ovarian Cancer Cell Lines. [PDF]

Cells
Mohl DA, Lagies S, Lonzer A, Pfäffle SP, Groß P, Benka M, Jäger M, Huber MC, Günther S, Plattner DA, Juhasz-Böss I, Backhaus C, Kammerer B.   +12 more
europepmc   +1 more source

Studies of Nucleosides and Nucleotides. XXVI. Further Studies on the Chlorination of Inosine Derivatives with Dimethylformamide-Thionyl Chloride Complex

, 1965
Morio Ikehara, Hitoshi Uno
openalex   +2 more sources

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Mutant p53 Associates with Human Equilibrative Nucleoside 1 Upregulation and Better Response to Adjuvant Gemcitabine in Intrahepatic Cholangiocarcinoma Patients. [PDF]

Int J Mol Sci
Deserti M, Relli V, Palloni A, Vasuri F, Malvi D, Degiovanni A, Rimedio S, Delbaldo C, Deiana C, Brandi G, Tavolari S.   +10 more
europepmc   +1 more source

Pentosyl Transfer Mechanisms of the Mammalian Nucleoside Phosphorylases

, 1968
Thomas A. Krenitsky
openalex   +1 more source