Results 241 to 250 of about 171,665 (294)

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

Epilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

Antiretroviral medications for pediatric use in the context of the Unified Health System: are there therapeutic gaps in Brazil? [PDF]

Rev Paul Pediatr
Costa SMD, Aguiar PM.
europepmc   +1 more source

Natural occurrence of drug resistance mutations to the HIV‐1 capsid inhibitor lenacapavir

HIV Medicine, EarlyView.
Abstract Aims Lenacapavir (LEN) is a first‐in‐class HIV‐1 capsid inhibitor. We investigated the natural occurrence of LEN drug resistance mutations (DRM) in HIV‐1 sequences from LEN treatment‐naïve individuals. Methods We analysed all available HIV‐1 capsid sequences (n = 21 646) from individuals never exposed to LEN from the Los Alamos National ...
A. Weibull Wärnberg, R. Ceña‐Diez, A. Sönnerborg, M. A. A. van de Klundert   +3 more
wiley   +1 more source

Association between Nucleoside and Nucleotide Reverse Transcriptase Inhibitor Use and Primary Open-Angle Glaucoma Risk in All of Us. [PDF]

Ophthalmology
Pham K, Jin F, Lee R, Di Rosa I, Salowe R, Ying GS, O'Brien JM.   +6 more
europepmc   +1 more source

Outcomes of real‐world initiation of long‐acting injectable cabotegravir and rilpivirine (LA‐I CAB + RPV) in individuals with viraemia: A systematic review of baseline characteristics, virological failure outcomes and discontinuations

HIV Medicine, EarlyView.
Abstract Background When using long‐acting injectable cabotegravir and rilpivirine (CAB + RPV) in individuals with viraemia, beyond small cohorts, little is known about baseline characteristics, virological failure outcomes, resistance emergence, re‐suppression and discontinuation.
Alexa Elias, Chloé Pasin, Melanie Smuk, Amy Paterson, Chloe M. Orkin   +4 more
wiley   +1 more source

Efficacy, bioavailability, and intracellular delivery of nanoparticle based drug encapsulated carbon for antiviral therapy. [PDF]

Sci Rep
Wu D, Bobat F, Yadavalli T, Shukla D.
europepmc   +1 more source

Interferon therapy for chronic hepatitis B virus infection affects nucleoside metabolism: a metabolomics study. [PDF]

BMC Gastroenterol
Ye X, Qiu R, He X, Hu Z, Zheng F, Huang X, Xie X, Chen F, Ou H.   +8 more
europepmc   +1 more source

Substituted benzylamino-2'-deoxyadenosine a modified nucleoside with radiosensitizing properties. [PDF]

Sci Rep
Datta M, Szczyrba A, Czaja A, Zdrowowicz M, Demkowicz S, Rak J.   +5 more
europepmc   +1 more source

HIV Low-Level Viremia is Not Related to Subsequent Virological Failure Under NNRTI-Based Regimens: A Multicenter Retrospective Study in China. [PDF]

Infect Drug Resist
Duan X, Song X, Lyu W, Li Y, Tang J, Cao W, Han Y, Li T.   +7 more
europepmc   +1 more source