Results 281 to 290 of about 235,474 (365)

Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments

open access: yesAging Cell, EarlyView.
The association of the aging scores with the clinical covariates suggests increased inflammation, strong predisposition to iron deficiency anemia, decline in muscle mass, and renal and hepatic functions with accelerated aging. ABSTRACT The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive ...
R. Moaddel   +17 more
wiley   +1 more source

Circular RNA Telomerase Reverses Endothelial Senescence in Progeria

open access: yesAging Cell, EarlyView.
TERT circRNA outperforms linear TERT mRNA in reversing the hallmarks of senescence. TERT circRNA more efficiently restores endothelial function and shows superior capability in enhancing mitochondrial function. ABSTRACT Telomeres shorten with each cell division, acting as a chronometer of cell age. The enzyme telomerase, primarily active in stem cells,
Weifeng Qin   +6 more
wiley   +1 more source

Bracken Fern Carcinogen, Ptaquiloside, Forms a Guanine O6-Adduct in DNA. [PDF]

open access: yesJ Agric Food Chem
Keskin F   +10 more
europepmc   +1 more source

Opportunities and Challenges of Population Pharmacogenomics

open access: yesAnnals of Human Genetics, EarlyView.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou   +3 more
wiley   +1 more source

Phenotypic screening of a focused nucleoside library [PDF]

open access: yes, 2016
Hulpia, Fabian, Van Calenbergh, Serge
core  

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