Results 291 to 300 of about 339,632 (390)

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

Science, 2014
B. Fowler, Bradley D. Gelfand, Younghee Kim, N. Kerur, Valeria Tarallo, Yoshio Hirano, Shoba Amarnath, D. Fowler, M. Radwan, M. Young, K. Pittman, P. Kubes, H. Agarwal, K. Parang, D. Hinton, A. Bastos-Carvalho, Shengjian Li, T. Yasuma, Takeshi Mizutani, Reo Yasuma, Charles B. Wright, J. Ambati   +21 more
semanticscholar   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Purification and Properties of Nucleoside Hydrolase from Pseudomonas fluorescens

, 1967
Masaaki Terada, Masamiti Tatibana, Osamu Hayaishi   +2 more
openalex   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

A potent GalNAc-siRNA drug, RBD1016, leads to sustained HBsAg reduction and seroconversion in mouse models of HBV infection. [PDF]

Mol Ther Nucleic Acids
Zheng S, Cao H, Zhang M, Guo C, Yan X, Sun Q, Zhang H, Liang Z, Gao S, Gan LM.   +9 more
europepmc   +1 more source

Homocitrullylaminoadenosine, a Nucleoside Isolated from Cordyceps militaris

, 1961
Nicholas M. Kredich, Armand J. Guarino
openalex   +1 more source

A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. AIDS Clinical Trials Group Study 175 Study Team.

New England Journal of Medicine, 1996
Scott M. Hammer, D. Katzenstein, Michael D. Hughes, Holly Gundacker, R. T. Schooley, Richard H. Haubrich, W. Keith Henry, Michael M. Lederman, J. P. Phair, Manette Niu, M. Hirsch, Thomas C. Merigan   +11 more
semanticscholar   +1 more source

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

Epilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

New Benzimidazole 3'-Deoxynucleosides: Synthesis and Antiherpes Virus Properties. [PDF]

Biomolecules
Arnautova AO, Aleksakhina IA, Zorina EA, Berzina MY, Fateev IV, Eletskaya BZ, Antonov KV, Smirnova OS, Paramonov AS, Kayushin AL, Andronova VL, Galegov GA, Kostromina MA, Zayats EA, Karpenko IL, Kotovskaya SK, Charushin VN, Esipov RS, Miroshnikov AI, Konstantinova ID.   +19 more
europepmc   +1 more source

Studies on Chemotherapeutic Agents.I. A Synthesis of Pyrimidine Nucleosides of D-glucuronic Acid and Its Derivatives

, 1966
T. Kishikawa, Tsuyoshi Yamazaki, Hidetaka Yuki   +2 more
openalex   +2 more sources