Results 311 to 320 of about 235,474 (365)

Brief Report: Resolution of Neuropsychiatric Adverse Events After Switching to a Doravirine-Based Regimen in the Open-Label Extensions of the DRIVE-AHEAD and DRIVE-FORWARD Trials. [PDF]

J Acquir Immune Defic Syndr
Moyle G, Meng F, Wan H, Sklar P, Plank RM, Lahoulou R.   +5 more
europepmc   +1 more source

Efficient convergent synthesis of 1,3-diazepinone nucleosides by ring-closing metathesis and direct glycosylation. [PDF]

RSC Adv
Hedger AK, Findell J, Barak DS, Schiffer CA, Watts JK, Ali A.   +5 more
europepmc   +1 more source

Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective

The FEBS Journal, EarlyView.
This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman, Alexandra Emerson, Peter M. Wilson, Karl A. Mulligan, Robert D. Ladner, Melissa J. LaBonte   +5 more
wiley   +1 more source

Purine Nucleoside Phosphorylase Deficiency: A Case Report of an Extremely Rare Disorder. [PDF]

Cureus
Alasmari BG, Ibrahim F, Wafa S, Alshehri A, Saeed M.   +4 more
europepmc   +1 more source

Activating AMPK improves pathological phenotypes due to mtDNA depletion

The FEBS Journal, EarlyView.
In a cellular model of mitochondrial disease characterized by progressive mitochondrial DNA (mtDNA) depletion, we found that advancing mitochondrial dysfunction triggers the early and specific activation of the mitochondria‐associated pool of AMP‐activated protein kinase (AMPK), a master regulator of energy homeostasis.
Gustavo Carvalho, Tran V. H. Nguyen, Bruno Repolês, Josefin M. E. Forslund, W. M. Ruchitha Rukmal Wijethunga, Farahnaz Ranjbarian, Isabela C. Mendes, Choco Michael Gorospe, Namrata Chaudhari, Micol Falabella, Mara Doimo, Sjoerd Wanrooij, Robert D. S. Pitceathly, Anders Hofer, Paulina H. Wanrooij   +14 more
wiley   +1 more source

An engineered aldolase enables the biocatalytic synthesis of 2'-functionalized nucleoside analogues. [PDF]

Nat Synth
Willmott M, Finnigan W, Birmingham WR, Derrington SR, Heath RS, Schnepel C, Hayes MA, Smith PD, Falcioni F, Turner NJ.   +9 more
europepmc   +1 more source

Bacterial transcriptional repressor NrdR – a flexible multifactorial nucleotide sensor

The FEBS Journal, EarlyView.
NrdR is a bacterial transcription factor that regulates the expression of all three types of ribonucleotide reductase, an essential enzyme for cell survival, in response to intracellular ATP and dATP levels. We have carried out a comprehensive biochemical, biophysical and structural study of the response of E. coli NrdR to ATP and dATP.
Inna Rozman Grinberg, Ornella Bimaï, Saher Shahid, Lena Philipp, Markel Martínez‐Carranza, Ipsita Banerjee, Daniel Lundin, Pål Stenmark, Britt‐Marie Sjöberg, Derek T. Logan   +9 more
wiley   +1 more source

Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Induced Neuropathy and Mitochondrial Toxicity: Limitations of the Poly-γ Hypothesis and the Potential Roles of Autophagy and Drug Transport. [PDF]

Pharmaceutics
Haynes J, Joshi A, Larue RC, Eisenmann ED, Govindarajan R.   +4 more
europepmc   +1 more source

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, EarlyView.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source

Chronic Hepatitis B Virus Persistence: Mechanisms and Insights. [PDF]

Cureus
Naidu S, Margeridon S.
europepmc   +1 more source