Results 311 to 320 of about 339,632 (390)

Natural occurrence of drug resistance mutations to the HIV‐1 capsid inhibitor lenacapavir

HIV Medicine, EarlyView.
Abstract Aims Lenacapavir (LEN) is a first‐in‐class HIV‐1 capsid inhibitor. We investigated the natural occurrence of LEN drug resistance mutations (DRM) in HIV‐1 sequences from LEN treatment‐naïve individuals. Methods We analysed all available HIV‐1 capsid sequences (n = 21 646) from individuals never exposed to LEN from the Los Alamos National ...
A. Weibull Wärnberg, R. Ceña‐Diez, A. Sönnerborg, M. A. A. van de Klundert   +3 more
wiley   +1 more source

The Electronic Properties of Cordycepin in the Adenine Nucleoside Landscape: A Theoretical Approach. [PDF]

Molecules
Karwowski BT.
europepmc   +1 more source

Serum Biomarkers in Atlantic Salmon for Differential Diagnosis of Cardiomyopathy Syndrome and Pancreas Disease: Proteomic Identification of Serum Fibrinogen to Enhance Troponin Immunoassay as Optimal Diagnostic Approach

Journal of Fish Diseases, EarlyView.
ABSTRACT Cardiac viral diseases are among the major causes of economic losses in Atlantic salmon (Salmo salar L.) aquaculture. These include cardiomyopathy syndrome (CMS) caused by piscine myocarditis virus (PMCV) and pancreas disease (PD) caused by Atlantic salmonid alphavirus (SAV).
Francesca Riva, Lauren Elaine Black, Kim D. Thompson, Philippe Sourd, Andrei Bordeianu, Christopher C. Chadwick, Hooman Moghadam, Jorge Del‐Pozo, Janina Costa, Richard Burchmore, Nicola Brady, Lewis Moore, Suzanne McGill, Mark McLaughlin, Peter David Eckersall   +14 more
wiley   +1 more source

Cross-tissue coordination between SLC nucleoside transporters regulates reproduction in Caenorhabditis elegans. [PDF]

PLoS Genet
Guan Y, Yu Y, Gao SM, Ding L, Zhao Q, Wang MC.   +5 more
europepmc   +1 more source

Precision oncology to overcome resistance in R/R AML in children and adults requires combinations of cytotoxic, targeted, and immunological treatments

Journal of Internal Medicine, EarlyView.
Abstract Although outcomes for newly diagnosed acute myeloid leukaemia (AML) have been incrementally improved over the last decades, management of relapsed and refractory (R/R) AML remains a medical challenge. A curative intent for R/R AML usually involves chemotherapy (with or without targeted therapy) with subsequent consolidation, including ...
Martin Jädersten, Ingrid Lilienthal, Christer Nilsson, Louisa Fredrikson, Cornelis Jan Pronk, Kristian Løvvik Juul‐Dam, Mika Kontro, Nikolas Herold   +7 more
wiley   +1 more source

Comprehensive nucleoside analysis of archaeal RNA modification profiles reveals an m⁷G in the conserved P loop of 23S rRNA. [PDF]

Cell Rep
Tsai YL, Wolf EJ, Fluke KA, Fuchs RT, Dai N, Johnson SR, Sun Z, Elkins L, Burkhart BW, Santangelo TJ, Corrêa IR.   +10 more
europepmc   +1 more source

Differentiation Trajectory of Virus‐Induced Tumour Cells in Rice Revealed by Single‐Cell RNA Sequencing

Plant Biotechnology Journal, EarlyView.
ABSTRACT Many plant viruses trigger abnormal differentiation and development of host cells, causing distinct symptoms. Here, in a single‐cell RNA sequence analysis, we find transcriptional heterogeneity between cells from rice leaf sheaths that are infected with rice black streaked dwarf virus (RBSDV) and from those that are virus‐free.
Nan Wu, Lu Gan, Qingqing Suo, Fei Yang, Wenwen Liu, Xifeng Wang, Huaibing Jin   +6 more
wiley   +1 more source

Optimizing scheduling in dual-pulse nucleoside labeling experiments for cell cycle analysis

Phelan A, Pospori C, Lo Celso C, Lee CF.
europepmc   +1 more source

Novel Potential Probiotics from Chinese Baijiu Fermentation Grains: Dual Action of <i>Lactiplantibacillus plantarum</i> LTJ1/LTJ48 in Uric Acid Reduction and Gut Microbiota Restoration for Hyperuricemia Therapy in Mice. [PDF]

Nutrients
Zhong F, Feng X, Cao J, Li M, Tian J, Wang J, Wang X, Luo X.   +7 more
europepmc   +1 more source