Results 171 to 180 of about 41,396 (291)

An enantioselective and modular platform for C4'-modified nucleoside analogue synthesis enabled by intramolecular trans-acetalizations. [PDF]

Nat Commun
Nuligonda T, Kumar G, Wang JW, Rajapaksha D, Elayan IA, Demir R, Meanwell NJ, Wang SF, Mahal LK, Brown A, Meanwell MW.   +10 more
europepmc   +1 more source

Single-molecule fluorescence detection of a tricyclic nucleoside analogue. [PDF]

Chem Sci, 2020
Samaan GN, Wyllie MK, Cizmic JM, Needham LM, Nobis D, Ngo K, Andersen S, Magennis SW, Lee SF, Purse BW.   +9 more
europepmc   +1 more source

Novel L-nucleoside analogue, 5-fluorotroxacitabine, displays potent efficacy against acute myeloid leukemia. [PDF]

Haematologica, 2021
Bankar A, Siriwardena TP, Rizoska B, Rydergård C, Kylefjord H, Rraklli V, Eneroth A, Pinho P, Norin S, Bylund J, Moses S, Bethell R, Kavanagh S, Maclean N, Gronda M, Wang X, Hurren R, Minden MD, Targett-Adams P, Schimmer AD, Albertella M.   +20 more
europepmc   +1 more source

Erratum to 'The management of chronic hepatitis B in the immunocompromised patient: recommendations from a single topic meeting' [J. Clin. Virol. 41 (4) 2008 243-254] [PDF]

, 2008
Barclay, Stephen, Benhamou, Yves, Cameron, Sheila, Carman, William, Hayes, Peter C, Mills, Peter R, Mutimer, David, Pol, Stanislas   +7 more
core   +1 more source

DNA Methylation Shapes Seed‐Borne Microbiome and Proteome Responses During Early Maize‐Beneficial Bacteria Interactions

Plant, Cell &Environment, EarlyView.
ABSTRACT Microorganism and plant interactions are crucial for development and environmental adaptation. Plant growth promoting bacteria enhance agricultural productivity in a sustainable manner, while epigenetic modifications such as DNA methylation regulate gene expression and adaptive responses.
Pedro Igor Zocateli, Geovanna Vitória de Olímpio, Felipe Astolpho de Almeida, Letícia Oliveira da Rocha, Diego Vinicius de Sena Martins, Sara Sangi, Fábio Lopes Olivares, Elyabe Monteiro de Matos, Juliana Siqueira, Lyderson Facio Viccini, Roberta Pena da Paschoa, Vanildo Silveira, Clícia Grativol   +12 more
wiley   +1 more source

Pritelivir for the Treatment of Nucleoside Analogue-Resistant Orolabial Herpes Simplex Virus 2 in a Person Living with HIV. [PDF]

J Assoc Med Microbiol Infect Dis Can
Purssell A, Leung K, Giguère P, Angel JB.   +3 more
europepmc   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Treatment of Three Ferrets Diagnosed with Ferret Systemic Coronaviral Disease Using the Nucleoside Analogue GS-441524. [PDF]

Animals (Basel)
Puffal J, Neece AJ, Scaletti F.
europepmc   +1 more source

Synthesis of nucleoside analogues. [PDF]

A basic introduction to a variety of nucleoside derivatives is described along with a selection of recent syntheses of the said compounds. Initial studies on the synthesis of the key furan based intermediate N-2,5-dihydro-5-(2,2-dimethyl-1,3-dioxolan-4-yl)furanyl trichloroacetamide which when hydrolysed to the free amine would yield a simple route to a
openaire  

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source