Results 51 to 60 of about 2,623 (158)
MedComm, Volume 6, Issue 10, October 2025.This review summarizes strategies to optimize lipid nanoparticles (LNPs) for improved targeting, endosomal escape, and safety. It highlights mRNA design, alternative delivery systems, and recent therapeutic advances across infectious diseases, cancer, and drug applications.
Xiaochi Li +7 more
wiley +1 more source
Gene Discovery and Data Sharing in Genome Wide Association Analyses: Lessons Form AIDS Genetic Restriction Genes [PDF]
, 2014 As genome wide association studies plus whole genome sequence analyses for complex human disease determinants are expanding, it seems useful to develop strategies to facilitate large data sharing, rapid replication and validation of provocative ...
Cherkasov, Nikolay +9 more
core +1 more source
Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.ABSTRACT Alzheimer's disease (AD) is the most prevalent cause of dementia, characterized by progressive cognitive decline and cerebral metabolic impairment. Yet, the therapeutic options for addressing the disease pathogenesis are limited. Here, we report an approach by targeting brain nucleoside homeostasis and energy metabolism to alleviate AD ...
Kuo‐Chen Wu +7 more
wiley +1 more source
Sampling protein motion and solvent effect during ligand binding. [PDF]
, 2012 An exhaustive description of the molecular recognition mechanism between a ligand and its biological target is of great value because it provides the opportunity for an exogenous control of the related process.
C. L. Motta +8 more
core +1 more source
, 2014 The standard of care for patients suffering cancer often includes treatment with nucleoside analogues (NAs). NAs are internalized by cell-specific nucleobase/nucleoside transporters and, after enzymatic activation (often one or more phosphorylation steps)
Balzarini, Jan +2 more
core
Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in "Saccharomyces cerevisiae" [PDF]
, 2013 The 25S rRNA of yeast contains several base modifications in the functionally important regions. The enzymes responsible for most of these base modifications remained unknown.
Entian, Karl-Dieter +3 more
core +1 more source
Isolation of Nucleoside Metabolizing Enzymes from Alaska Pea Seeds (Pisum sativum L. cultivar Alaska) [PDF]
, 2013 The activities of number of metabolizing enzymes were determined from dry Alaska Pea Seeds (Pisum sativum L. cultivar Alaska). Then tested for presence of three groups of enzymes; nucleosidase, deaminases and phosphorylases. The highest activity of the
Altawil, Zahrah Mohammad
core +1 more source
NUCLEOSIDE CATABOLIZING ACTIVITIES IN SELECTED SEEDS [PDF]
, 2016 The efficacy of pyrimidine and purine nucleotide metabolism plays a critical role in the progression of biological systems. The process of nucleotide degradation exists in all organisms. The nucleoside degradation and salvage of nucleotides, nucleosides,
ALMARWANI, NOGOOD
core +1 more source
Human APOBEC1 cytidine deaminase edits HBV DNA [PDF]
, 2009 Retroviruses, hepadnaviruses, and some other retroelements are vulnerable to editing by single stranded DNA cytidine deaminases. Of the eleven human genes encoding such enzymes, eight have demonstrable enzymatic activity.
Gonzalez, Minerva Cervantes +5 more
core +5 more sources
SURVEY OF NUCLEOSIDE DEGRADING ENZYME ACTIVITIES IN SOYBEAN, CORN AND YELLOW LUPIN [PDF]
, 2014 Efficient pyrimidine and purine nucleotide metabolism is essential for healthy growth and development of all organisms. Significant energy cost reduction and a mutation bypass mechanism is afforded via the recycling pathways of nucleotide metabolism in ...
Ustynov, Sergiy
core +1 more source