Results 251 to 260 of about 193,772 (411)

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller   +4 more
wiley   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

open access: yesJournal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy   +7 more
wiley   +1 more source

NMR-Based Metabolomic Approach to Study Growth of <i>Phaseolus vulgaris</i> L. Seedlings Through Leaf Application of Nanofertilizers and Biofertilizers. [PDF]

open access: yesInt J Mol Sci
López-Vargas ER   +7 more
europepmc   +1 more source

PMR study of N6, N6-dimethyladenosine conformations under high pressure [PDF]

open access: yes, 1977
Lang, Elmar   +2 more
core   +1 more source

On‐Resin Recycling of Acid‐Labile Linker Enables the Reuse of Solid Support for Fmoc‐Based Solid Phase Synthesis

open access: yesMacromolecular Rapid Communications, EarlyView.
This study introduces the first recyclable and reusable resin for Fmoc‐based solid phase synthesis (SPS) of oligamide‐based structures through the regeneration of a cyclic acetal‐based linker on Tentagel resins. Even after multiple recycling and reuse cycles of the solid phase, consistently high yields and high‐purity products are obtained. Abstract In
Nicholas Jäck, Laura Hartmann
wiley   +1 more source

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