Results 231 to 240 of about 130,320 (304)

4'-Modified Nucleosides for Antiviral Drug Discovery: Achievements and Perspectives.

Accounts of Chemical Research, 2022
ConspectusModified nucleosides show therapeutic promise for antiviral therapies. However, issues including the emergence of drug resistance, toxicity, and coinfections have posed new challenges for nucleoside-based antiviral drug discovery, particularly ...
Junbiao Chang
semanticscholar   +1 more source

Binding of DNA Nucleobases and Nucleosides with Graphene

ChemPhysChem, 2009
Neenu Varghese, Umesha Mogera, Anindya Das   +2 more
exaly   +2 more sources

Mass spectrometry analysis of nucleosides and nucleotides

Mass Spectrometry Reviews, 2014
Ed Dudley
exaly   +2 more sources

Fluorinated nucleosides

Carbohydrate Research, 2000
The synthesis and biological activity of deoxyfluoro nucleosides are reviewed.
Krzysztof W Pankiewicz, Krzysztof W Pankiewicz   +1 more
exaly   +3 more sources

Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases

Pharmacology & Therapeutics, 2000
Nucleoside monophosphate kinases catalyze the reversible phosphotransferase reaction between nucleoside triphosphates and monophosphates, i.e., monophosphates are converted to their corresponding diphosphate form. These enzymes play an important role in the synthesis of nucleotides that are required for a variety of cellular metabolic processes, as ...
A R, Van Rompay, M, Johansson, A, Karlsson   +2 more
openaire   +2 more sources

The stilbene derivatives, nucleosides, and nucleosides modified by stilbene derivatives.

Bioorganic chemistry (Print), 2019
In this short review, including 187 references, the issues of biological activity of stilbene derivatives and nucleosides and the biological and medicinal potential of fusion of these two classes are discussed.
H. Krawczyk
semanticscholar   +1 more source

Urinary nucleosides

Mass Spectrometry Reviews, 1998
The methods of analysis, origins, and clinical significance of urinary nucleosides are reviewed through 1997. Structures, chromatographic and mass spectral data and references to the clinical literature are presented for each of the 57 nucleosides currently identified in normal and pathogenic human urine samples. Data from the HPLC separation and GC/MS
Karl H Schram
exaly   +3 more sources

Advancement in the development of heterocyclic nucleosides for the treatment of cancer - A review

Nucleosides, Nucleotides & Nucleic Acids, 2019
Cancer diseases are widely recognised as an important medical problem and killing millions of people in a year. Chemotherapeutic drugs are successful against cancer in many cases and different compounds, including the analogues of natural substances, may
A. Mirza
semanticscholar   +1 more source

Chromatography of nucleosides

Journal of Chromatography A, 1980
Abstract The chromatographic parameters affectingthe reversed-phase high-performance liquid chromatographic (HPLC) separation of major and modified nucleosides with a μBondapak C 18 column have been studied. This investigation has resulted in the HPLC separation of eighteen nucleosides in a single analysis. The parameters studied include: the mobile
C W, Gehrke, K C, Kuo, R W, Zumwalt
openaire   +2 more sources

Bromination of nucleosides

Experientia, 1970
Mit N-Bromsuccinimid konnen Nukleoside in Dimethylformamid mit guter Ausbeute zu den in 5-Stellung bromierten Derivaten umgewandelt werden.
P C, Srivastava, K, Nagpal
openaire   +2 more sources