Results 211 to 220 of about 37,185 (261)
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The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors
Clinics in Liver Disease, 2011This article introduces one of the most diverse classes of direct-acting antivirals for hepatitis C, the nucleoside and non-nucleoside NS5B polymerase inhibitors. Through a systematic review of the published literature, we describe their structure, mechanism of action, issues with resistance, and clinical effectiveness shown in the latest clinical ...
Fernando E, Membreno, Eric J, Lawitz
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Archiv der Pharmazie, 2006
AbstractNovel phenyl‐branched cyclopropyl nucleosides, phosphonates, and phosphonic acid analogues were designed and synthesized as potential antiviral agents. Coupling of the mesylate 10 with natural bases (U, T, C, A) and desilylation/hydrolysis afforded a series of novel cyclopropyl nucleosides 15–18.
Chang, Hyun Oh, Joon Hee, Hong
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AbstractNovel phenyl‐branched cyclopropyl nucleosides, phosphonates, and phosphonic acid analogues were designed and synthesized as potential antiviral agents. Coupling of the mesylate 10 with natural bases (U, T, C, A) and desilylation/hydrolysis afforded a series of novel cyclopropyl nucleosides 15–18.
Chang, Hyun Oh, Joon Hee, Hong
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Mass Spectrometry Reviews, 1998
The methods of analysis, origins, and clinical significance of urinary nucleosides are reviewed through 1997. Structures, chromatographic and mass spectral data and references to the clinical literature are presented for each of the 57 nucleosides currently identified in normal and pathogenic human urine samples. Data from the HPLC separation and GC/MS
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The methods of analysis, origins, and clinical significance of urinary nucleosides are reviewed through 1997. Structures, chromatographic and mass spectral data and references to the clinical literature are presented for each of the 57 nucleosides currently identified in normal and pathogenic human urine samples. Data from the HPLC separation and GC/MS
exaly +3 more sources
Enzyme, 2017
A study of the steady-state kinetics of the crystalline brewer’s yeast (Saccharomyces carlsbergensis) nucleoside diphosphokinase, with the magnesium complexes of the adenine and thymidine nucleotides as reactants, has led to a postulated kinetic mechanism which proceeds through a substituted enzyme.
Stephen A. Kuby +5 more
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A study of the steady-state kinetics of the crystalline brewer’s yeast (Saccharomyces carlsbergensis) nucleoside diphosphokinase, with the magnesium complexes of the adenine and thymidine nucleotides as reactants, has led to a postulated kinetic mechanism which proceeds through a substituted enzyme.
Stephen A. Kuby +5 more
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Role of Nucleoside Transporters in Nucleoside-Derived Drug Sensitivity
Nucleosides, Nucleotides and Nucleic Acids, 2010Nucleoside-derived drugs are currently used clinically as anticancer drugs. To exert their pharmacological action first they need to enter into the cell across plasma membrane transporters and be metabolized. Thus, efficacy of treatment and acquisition of resistance can rely on a variety of events.
Molina-Arcas M, Pastor-Anglada M
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Tetrahedron Letters, 1996
Abstract Oxidation of H-phosphonate, H-phosphonothioate, or H-phosphonodithioate monoesters with iodine in pyridine in the presence of trimethylsilyl chloride, followed by addition of triethylamine trishydrofluoride (TAF) furnished rapid and quantitative formation of the corresponding phosphorofluoridate, phosphorofluoridothioate, or ...
Martin Bollmark, Jacek Stawiński
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Abstract Oxidation of H-phosphonate, H-phosphonothioate, or H-phosphonodithioate monoesters with iodine in pyridine in the presence of trimethylsilyl chloride, followed by addition of triethylamine trishydrofluoride (TAF) furnished rapid and quantitative formation of the corresponding phosphorofluoridate, phosphorofluoridothioate, or ...
Martin Bollmark, Jacek Stawiński
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Pyrazolylboratozinc Complexes of Nucleosides and Nucleoside Analogues
European Journal of Inorganic Chemistry, 2003AbstractAttachment of deprotonated nucleosides or of alkylated nucleobases, as their analogues, to zinc was achieved by condensation reactions between TpZn‐OH complexes and nucleobase derivatives. Pyrazolylboratozinc complexes with derivatives of uracil, thymine, guanine, xanthine and hypoxanthine were obtained and characterized by structure ...
Dirk Badura, Heinrich Vahrenkamp
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Urinary Nucleosides and Deoxynucleosides
2018Urinary nucleosides and deoxynucleosides are mainly known as metabolites of RNA turnover and oxidative damage of DNA. For several decades these metabolites have been examined for their potential use in disease states including cancer and oxidative stress.
Małgorzata, Patejko +4 more
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