Results 71 to 80 of about 75,018 (265)

NAP1-assisted nucleosome assembly on DNA measured in real time by single-molecule magnetic tweezers.

PLoS ONE, 2012
While many proteins are involved in the assembly and (re)positioning of nucleosomes, the dynamics of protein-assisted nucleosome formation are not well understood.
Rifka Vlijm, Jeremy S J Smitshuijzen, Alexandra Lusser, Cees Dekker   +3 more
doaj   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Distinct modes of regulation by chromatin encoded through nucleosome positioning signals.

PLoS Computational Biology, 2008
The detailed positions of nucleosomes profoundly impact gene regulation and are partly encoded by the genomic DNA sequence. However, less is known about the functional consequences of this encoding.
Yair Field, Noam Kaplan, Yvonne Fondufe-Mittendorf, Irene K Moore, Eilon Sharon, Yaniv Lubling, Jonathan Widom, Eran Segal   +7 more
doaj   +1 more source

Insights into distinct regulatory modes of nucleosome positioning

BMC Genomics, 2009
Background The nucleosome is the fundamental unit of eukaryotic genomes. Experimental evidence suggests that the genomic DNA sequence and a variety of protein factors contribute to nucleosome positioning in vivo.
Feng Jihua, Xiang Qian, Dai Xianhua, Dai Zhiming, Deng Yangyang, Wang Jiang   +5 more
doaj   +1 more source

Structural features based genome-wide characterization and prediction of nucleosome organization

BMC Bioinformatics, 2012
Background Nucleosome distribution along chromatin dictates genomic DNA accessibility and thus profoundly influences gene expression. However, the underlying mechanism of nucleosome formation remains elusive.
Gan Yanglan, Guan Jihong, Zhou Shuigeng, Zhang Weixiong   +3 more
doaj   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Modulation of Epigenetic Control by Advanced Molecular Tweezers

Chemistry – A European Journal, EarlyView.
Tailored dimeric molecular tweezers recognize the DNA‐binding part of Histone H4 and interrupt the essential histone‐DNA interaction. ABSTRACT This work addresses the question if supramolecular systems can be tailored to interfere with posttranslational modifications (PTM) and epigenetics.
My‐Hue‐Le, Bianca Kamba, Anja Matena, Christine Beuck, Victoria Momand, Spiros Salvanos, Jessica Vossen, Mike Blueggel, Thomas Schrader, Peter Bayer   +9 more
wiley   +1 more source

Chromatin Remodelling Complexes in Plant Adaptation to Abiotic Stress: Mechanisms and Perspectives. [PDF]

Plant Cell Environ
ABSTRACT As sessile organisms, plants have evolved elaborate epigenetic regulatory networks to adapt to a wide range of abiotic stress. Chromatin remodelling is a core epigenetic regulatory mechanism that refers to the process by which chromatin remodelling complexes mediate dynamic changes in chromatin spatial conformation and DNA accessibility ...
Zhang X, Zhang Y, Li J.
europepmc   +2 more sources

A WGCNA‐Based Approach to Identify Hub Genes Associated With TNM Staging in Urothelial Bladder Carcinoma

Cancer Nexus, EarlyView.
ABSTRACT In this study, we identified gene modules and representative candidate biomarkers linked to clinical progression in patients with UBC. Weighted gene co‐expression network analysis (WGCNA) was used to identify gene modules associated with TNM staging in UBC patients.
Arshia Azmoudeh
wiley   +1 more source

Sizing and concentration analysis of cfDNA using Biabooster technology: Results from a prospective plasma‐based collection of 77 patients with locally advanced unresectable esophageal cancer

International Journal of Cancer, EarlyView.
What's New? This study introduces a novel approach for detecting locally advanced esophageal carcinoma using cell‐free DNA (cfDNA) analysis through a highly sensitive fragmentome assay. Unlike traditional sequencing‐based methods that are limited by the absence of specific mutations in esophageal tumors, our method offers an alternative by quantifying ...
Anouchka Modesto, Sophie Gibert, Caroline Delmas, David Tougeron, Amaury Paumier, Alexandre Taillez, Samuel Le Sourd, Delphine Argo Leignel, Philippe Ronchin, Ariane Darut Jouve, Véronique Vendrely, Olivier Riou, Jérôme Martin‐Babau, Thomas Leroy, Laurent Quéro, Naïma Hanoun, Pierre Cordelier, Veronica Pezzella, Jean Pierre Delord, Rosine Guimbaud, Elizabeth Moyal, Catherine Seva   +21 more
wiley   +1 more source