Nucleosome-coupled expression differences in closely-related species
BMC Genomics, 2011 Background Genome-wide nucleosome occupancy is negatively related to the average level of transcription factor motif binding based on studies in yeast and several other model organisms.
Gebbia Marinella +6 more
doaj +1 more source
Theory of Nucleosome Corkscrew Sliding in the Presence of Synthetic DNA Ligands
, 2004 Histone octamers show a heat-induced mobility along DNA. Recent theoretical studies have established two mechanisms that are qualitatively and quantitatively compatible with in vitro experiments on nucleosome sliding: Octamer repositiong through one ...
Kulic, Igor M. +2 more
core +2 more sources
High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier. [PDF]
, 2019 Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II) must overcome during transcription. A high-resolution description of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol II ...
Brown, Aidan I +9 more
core +2 more sources
Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding
Nucleic Acids Research, 2020 Nuclear proteins bind chromatin to execute and regulate genome-templated processes. While studies of individual nucleosome interactions have suggested that an acidic patch on the nucleosome disk may be a common site for recruitment to chromatin, the ...
Aleksandra Skrajna +12 more
semanticscholar +1 more source
ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Dimitrov S. +6 more
core +1 more source
Linking stochastic fluctuations in chromatin structure and gene expression. [PDF]
PLoS Biology, 2013 The number of mRNA and protein molecules expressed from a single gene molecule fluctuates over time. These fluctuations have been attributed, in part, to the random transitioning of promoters between transcriptionally active and inactive states, causing ...
Christopher R Brown +4 more
doaj +1 more source
Structural Features of Transcription Factors Associating with Nucleosome Binding.
Molecules and Cells, 2019 Fate-changing transcription factors (TFs) scan chromatin to initiate new genetic programs during cell differentiation and reprogramming. Yet the protein structure domains that allow TFs to target nucleosomal DNA remain unexplored. We screened diverse TFs
Meilin Fernandez Garcia +7 more
semanticscholar +1 more source
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate.
Molecules and Cells, 2020 LSD1 (lysine specific demethylase; also known as KDM1A), the first histone demethylase discovered, regulates cell-fate determination and is overexpressed in multiple cancers.
Sang-Ah Kim +4 more
semanticscholar +1 more source
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization [PDF]
, 2015 The ends of eukaryotic chromosomes need to be protected from the activation of a DNA damage response that leads the cell to replicative senescence or apoptosis.
Alicata, Claudia +8 more
core +3 more sources
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source