Results 41 to 50 of about 148,408 (312)
Nucleosomes affect local transformation efficiency [PDF]
, 2012 Genetic transformation is a natural process during which foreign DNA enters a cell and integrates into the genome. Apart from its relevance for horizontal gene transfer in nature, transformation is also the cornerstone of today's recombinant gene ...
Aslankoohi, Elham +6 more
core +2 more sources
Nature Communications, 2020 Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the membraneless compartmentalization of the nucleus. Because chromatin compaction and LLPS are collective phenomena, linking their modulation to the physicochemical ...
Stephen E. Farr +4 more
semanticscholar +1 more source
Manipulating chromatin architecture in C. elegans
Epigenetics & Chromatin, 2022 Background Nucleosome-mediated chromatin compaction has a direct effect on the accessibility of trans-acting activators and repressors to DNA targets and serves as a primary regulatory agent of genetic expression. Understanding the nature and dynamics of
John L. Carter +3 more
doaj +1 more source
The size of the nucleosome [PDF]
, 2011 The structural origin of the size of the 11 nm nucleosomal disc is addressed. On the nanometer length-scale the organization of DNA as chromatin in the chromosomes involves a coiling of DNA around the histone core of the nucleosome.
A. Travers +3 more
core +2 more sources
Primary Role of the Nucleosome.
Molecules and Cells, 2020 Whereas the core nucleosome is thought to serve as a packaging device for the coiling and contraction in length of genomic DNA, we suggest that it serves primarily in the regulation of transcription.
R. Kornberg, Y. Lorch
semanticscholar +1 more source
Genome-scale identification of nucleosome organization by using 1000 porcine oocytes at different developmental stages. [PDF]
PLoS ONE, 2017 The nucleosome is the basic structural unit of chromosomes, and its occupancy and distribution in promoters are crucial for the regulation of gene expression.
Chenyu Tao +5 more
doaj +1 more source
BMC Evolutionary Biology, 2011 Background Divergence of transcription factor binding sites is considered to be an important source of regulatory evolution. The associations between transcription factor binding sites and phenotypic diversity have been investigated in many model ...
Chu Wen-Yi +4 more
doaj +1 more source
Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model
Nature Communications, 2022 Here the authors provide a multi-omic study of the nucleosome landscape in LNCaP cells and observe nine functional nucleosome states each with characteristic nucleosome footprints.
Tianbao Li +7 more
doaj +1 more source
High nucleosome occupancy is encoded at human regulatory sequences. [PDF]
PLoS ONE, 2010 Active eukaryotic regulatory sites are characterized by open chromatin, and yeast promoters and transcription factor binding sites (TFBSs) typically have low intrinsic nucleosome occupancy. Here, we show that in contrast to yeast, DNA at human promoters,
Desiree Tillo +9 more
doaj +1 more source
ISRN Molecular Biology, 2012 Nucleosome positioning is not only related to genomic DNA compaction but also to other biological functions. After the chromatin is digested by micrococcal nuclease, nucleosomal (nucleosome-bound) DNA fragments can be sequenced and mapped on the genomic DNA sequence.
openaire +2 more sources