Results 41 to 50 of about 72,244 (252)
Proceedings of the National Academy of Sciences, 1997 Archaeacontain histones that have primary sequences in common with eukaryal nucleosome core histones and a three-dimensional structure that is essentially only the histone fold. Here we report the results of experiments that document that archaeal histones compact DNAin vivointo structures similar to the structure formed by the histone (H3+H4)2tetramer
S L, Pereira +3 more
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BMC Genomics, 2010 Background Recently, a number of high-resolution genome-wide maps of nucleosome locations in S. cerevisiae have been derived experimentally. However, nucleosome positions are determined in vivo by the combined effects of numerous factors.
Deng Yangyang +6 more
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Structural characterization of H3K56Q nucleosomes and nucleosomal arrays [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010 The post-translational modification of histones is a key mechanism for the modulation of DNA accessibility. Acetylated lysine 56 in histone H3 is associated with nucleosome assembly during replication and DNA repair, and is thus likely to predominate in regions of chromatin containing nucleosome-free regions.
Shinya, Watanabe +6 more
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Thermodynamic modeling of genome-wide nucleosome depleted regions in yeast.
PLoS Computational Biology, 2021 Nucleosome positioning in the genome is essential for the regulation of many nuclear processes. We currently have limited capability to predict nucleosome positioning in vivo, especially the locations and sizes of nucleosome depleted regions (NDRs). Here,
Hungyo Kharerin, Lu Bai
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Control of nucleosome movement: To space or not to space nucleosomes? [PDF]
Epigenetics, 2010 A key feature of ATP-dependent chromatin remodeling complexes is how they control the ability of the complex to translocate along DNA within the context of a nucleosome. Although these complexes generally initiate DNA translocation near the dyad axis of the nucleosome, the progression and eventual termination is regulated in quite distinct ways.
Punit, Prasad, Blaine, Bartholomew
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Nucleosome packaging and nucleosome positioning of genomic DNA [PDF]
Proceedings of the National Academy of Sciences, 1997 The goals of this study were to assess the extent to which bulk genomic DNA sequences contribute to their own packaging in nucleosomes and to reveal the relationship between nucleosome packaging and positioning. Using a competitive nucleosome reconstitution assay, we found that at least 95% of bulk DNA sequences have an affinity for ...
P T, Lowary, J, Widom
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Nucleosome-coupled expression differences in closely-related species
BMC Genomics, 2011 Background Genome-wide nucleosome occupancy is negatively related to the average level of transcription factor motif binding based on studies in yeast and several other model organisms.
Gebbia Marinella +6 more
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Linking stochastic fluctuations in chromatin structure and gene expression. [PDF]
PLoS Biology, 2013 The number of mRNA and protein molecules expressed from a single gene molecule fluctuates over time. These fluctuations have been attributed, in part, to the random transitioning of promoters between transcriptionally active and inactive states, causing ...
Christopher R Brown +4 more
doaj +1 more source
Advanced Science, EarlyView.Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater +13 more
wiley +1 more source