Results 31 to 40 of about 148,408 (312)

Nucleosome Positioning, Nucleosome Spacing and the Nucleosome Code [PDF]

Journal of Biomolecular Structure and Dynamics, 2010
Nucleosome positioning has been the subject of intense study for many years. The properties of micrococcal nuclease, the enzyme central to these studies, are discussed. The various methods used to determine nucleosome positions in vitro and in vivo are reviewed critically.
openaire   +2 more sources

Nucleosome—nucleosome interaction in chromatin

FEBS Letters, 1979
The available data suggest that transcriptional activity of chromatin is connected with its structural changes [ 1,2]. According to the electron microscope evidence, the elementary 100 A chromatin thread can exist in two main states, i.e., in a compact state, which is characterized by tight packing of nucleosomes and in an extended state when the ...
Pospelov, V.A., Svetlikova, S.B., Vorob'ev, V.I.   +2 more
openaire   +2 more sources

The histone chaperone FACT modulates nucleosome structure by tethering its components

Life Science Alliance, 2018
The histone chaperone FACT functions by tethering partial components of the nucleosome, thereby assisting nucleosome disassembly and reassembly during transcription.
Tao Wang, Yang Liu, Garrett Edwards, Daniel Krzizike, Hataichanok Scherman, Karolin Luger   +5 more
doaj   +1 more source

Structural and biochemical analyses of monoubiquitinated human histones H2B and H4 [PDF]

Open Biology, 2016
Monoubiquitination is a major histone post-translational modification. In humans, the histone H2B K120 and histone H4 K31 residues are monoubiquitinated and may form transcriptionally active chromatin.
Shinichi Machida, Satoshi Sekine, Yuuki Nishiyama, Naoki Horikoshi, Hitoshi Kurumizaka   +4 more
doaj   +1 more source

Structural basis of nucleosome-dependent cGAS inhibition

Science, 2020
Saving a host cell from itself A fundamental mammalian defense mechanism against pathogens and damaged cellular DNA is to recognize DNA fragments in the cytosol and trigger an inflammatory response.
J. Boyer, C. Spangler, J. Strauss, A. Cesmat, Pengda Liu, R. McGinty, Qi Zhang   +6 more
semanticscholar   +1 more source

Two distinct modes of nucleosome modulation associated with different degrees of dependence of nucleosome positioning on the underlying DNA sequence

BMC Genomics, 2009
Background The nucleosome is the fundamental unit of eukaryotic genomes. Its positioning plays a central role in diverse cellular processes that rely on access to genomic DNA.
Wang Jiang, Feng Jihua, Xiang Qian, Dai Xianhua, Dai Zhiming, Deng Yangyang, He Caisheng   +6 more
doaj   +1 more source

Contributions of histone H3 nucleosome core surface mutations to chromatin structures, silencing and DNA repair. [PDF]

PLoS ONE, 2011
Histone H3 mutations in residues that cluster in a discrete region on the nucleosome surface around lysine 79 of H3 affect H3-K79 methylation, impair transcriptional silencing in subtelomeric chromatin, and reveal distinct contributions of histone H3 to ...
Michel Fink, Jeffrey S Thompson, Fritz Thoma   +2 more
doaj   +1 more source

Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]

, 2015
BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M, Le Roch, Karine G, Lonardi, Stefano, Lu, Xueqing Maggie, Nasseri, Sara, Pokhriyal, Neeti   +5 more
core   +2 more sources

HP1 reshapes the nucleosome core to promote phase separation of heterochromatin

Nature, 2019
Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus1,2.
S. Sanulli, Michael J. Trnka, V. Dharmarajan, Ryan W. Tibble, B. Pascal, A. Burlingame, P. Griffin, J. Gross, G. Narlikar   +8 more
semanticscholar   +1 more source

Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations

Cell Discovery, 2021
Substitution of lysine 36 with methionine in histone H3.3 (H3.3K36M) is an oncogenic mutation that inhibits SETD2-mediated histone H3K36 tri-methylation in tumors.
Yingying Liu, Yanjun Zhang, Han Xue, Mi Cao, Guohui Bai, Zongkai Mu, Yanli Yao, Shuyang Sun, Dong Fang, Jing Huang   +9 more
doaj   +1 more source