Results 11 to 20 of about 148,408 (312)
The Ies6 subunit is essential for INO80-mediated nucleosome organization [PDF]
Scientific ReportsATP-dependent nucleosome remodelers of the INO80 family regulate chromatin by sliding, spacing and positioning nucleosomes. The INO80 remodeler is organized into structural modules that regulate its remodeling activity.
Ashish Kumar Singh +1 more
doaj +2 more sources
Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT
Science, 2022 During gene transcription, RNA polymerase II (RNAPII) traverses nucleosomes in chromatin, but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained structures of the RNAPII elongation complex (EC) passing through a nucleosome in
H. Ehara +4 more
semanticscholar +1 more source
Structure of nucleosome-bound human PBAF complex
bioRxiv, 2022 BAF and PBAF are mammalian SWI/SNF family chromatin remodeling complexes that possess multiple histone/DNA-binding subunits and create nucleosome-depleted/free regions for transcription activation. Despite structural studies of nucleosome-bound human BAF
Li Wang +8 more
semanticscholar +1 more source
Predicting human nucleosome occupancy from primary sequence. [PDF]
PLoS Computational Biology, 2008 Nucleosomes are the fundamental repeating unit of chromatin and comprise the structural building blocks of the living eukaryotic genome. Micrococcal nuclease (MNase) has long been used to delineate nucleosomal organization.
Shobhit Gupta +5 more
doaj +1 more source
Structural Transition of the Nucleosome during Transcription Elongation
Cells, 2023 In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during ...
Tomoya Kujirai +3 more
doaj +1 more source
NucleoMap: A computational tool for identifying nucleosomes in ultra-high resolution contact maps.
PLoS Computational Biology, 2022 Although poorly positioned nucleosomes are ubiquitous in the eukaryotic genome, they are difficult to identify with existing nucleosome identification methods.
Yuanhao Huang, Bingjiang Wang, Jie Liu
doaj +1 more source
H3.3-H4 tetramer splitting events feature cell-type specific enhancers. [PDF]
PLoS Genetics, 2013 Previously, we reported that little canonical (H3.1-H4)(2) tetramers split to form "hybrid" tetramers consisted of old and new H3.1-H(4) dimers, but approximately 10% of (H3.3-H4)2 tetramers split during each cell cycle.
Chang Huang +7 more
doaj +1 more source
Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory
Nature Structural & Molecular Biology, 2022 Throughout the genome, nucleosomes often form regular arrays that differ in nucleosome repeat length (NRL), occupancy of linker histone H1 and transcriptional activity. Here, we report cryo-EM structures of human H1-containing tetranucleosome arrays with
Marco Dombrowski +4 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences, 1997 Archaeacontain histones that have primary sequences in common with eukaryal nucleosome core histones and a three-dimensional structure that is essentially only the histone fold. Here we report the results of experiments that document that archaeal histones compact DNAin vivointo structures similar to the structure formed by the histone (H3+H4)2tetramer
S L, Pereira +3 more
openaire +2 more sources
Structural basis of nucleosome retention during transcription elongation
Science, 2022 In eukaryotes, RNA polymerase (Pol) II transcribes chromatin and must move past nucleosomes, often resulting in nucleosome displacement. How Pol II unwraps the DNA from nucleosomes to allow transcription and how DNA rewraps to retain nucleosomes has been
Martin Filipovski +3 more
semanticscholar +1 more source