Results 11 to 20 of about 75,018 (265)
Dynamic Changes of ctDNA-Based MRD and Genomic Mutations Predict Prognosis in ESCC Treated With Definitive Radiotherapy. [PDF]
Cancer SciIn patients with esophageal squamous cell carcinoma receiving definitive radiotherapy combined with systemic therapy, posttreatment TP53 mutation clearance and ctDNA‐MRD negativity predict favorable outcomes, whereas persistent ctDNA signals indicate elevated relapse risk, supporting nucleosome‐ and MRD‐informed surveillance and risk‐stratification ...
Liu S +9 more
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Nucleosome Positioning, Nucleosome Spacing and the Nucleosome Code [PDF]
Journal of Biomolecular Structure and Dynamics, 2010 Nucleosome positioning has been the subject of intense study for many years. The properties of micrococcal nuclease, the enzyme central to these studies, are discussed. The various methods used to determine nucleosome positions in vitro and in vivo are reviewed critically.
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Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer [PDF]
Cancers, 2017 Traditionally the stratification of many cancers involves combining tumour and clinicopathological features (e.g., patient age; tumour size, grade, receptor status and location) to inform treatment options and predict recurrence risk and survival. However, current biomarkers often require invasive excision of the tumour for profiling, do not allow ...
Peter McAnena +2 more
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A systematic analysis of nucleosome core particle and nucleosome-nucleosome stacking structure [PDF]
Scientific Reports, 2018 AbstractChromatin condensation is driven by the energetically favourable interaction between nucleosome core particles (NCPs). The close NCP-NCP contact, stacking, is a primary structural element of all condensed states of chromatin in vitro and in vivo.
Korolev, Nikolay +2 more
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Nucleosome—nucleosome interaction in chromatin
FEBS Letters, 1979 The available data suggest that transcriptional activity of chromatin is connected with its structural changes [ 1,2]. According to the electron microscope evidence, the elementary 100 A chromatin thread can exist in two main states, i.e., in a compact state, which is characterized by tight packing of nucleosomes and in an extended state when the ...
Pospelov, V.A. +2 more
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Structural and biochemical analyses of monoubiquitinated human histones H2B and H4 [PDF]
Open Biology, 2016 Monoubiquitination is a major histone post-translational modification. In humans, the histone H2B K120 and histone H4 K31 residues are monoubiquitinated and may form transcriptionally active chromatin.
Shinichi Machida +4 more
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Contributions of histone H3 nucleosome core surface mutations to chromatin structures, silencing and DNA repair. [PDF]
PLoS ONE, 2011 Histone H3 mutations in residues that cluster in a discrete region on the nucleosome surface around lysine 79 of H3 affect H3-K79 methylation, impair transcriptional silencing in subtelomeric chromatin, and reveal distinct contributions of histone H3 to ...
Michel Fink +2 more
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Cell Discovery, 2021 Substitution of lysine 36 with methionine in histone H3.3 (H3.3K36M) is an oncogenic mutation that inhibits SETD2-mediated histone H3K36 tri-methylation in tumors.
Yingying Liu +9 more
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Physical Review Letters, 2008 We present a statistical-mechanical model for the positioning of nucleosomes along genomic DNA molecules as a function of the strength of the binding potential and the chemical potential of the nucleosomes. We show that a significant section of the DNA is composed of two-level nucleosome switching regions where the nucleosome distribution undergoes a ...
David J, Schwab +3 more
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Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model
Nature Communications, 2022 Here the authors provide a multi-omic study of the nucleosome landscape in LNCaP cells and observe nine functional nucleosome states each with characteristic nucleosome footprints.
Tianbao Li +7 more
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