Results 11 to 20 of about 72,244 (252)
The Effect of Micrococcal Nuclease Digestion on Nucleosome Positioning Data [PDF]
PLoS ONE, 2010 Eukaryotic genomes are packed into chromatin, whose basic repeating unit is the nucleosome. Nucleosome positioning is a widely researched area. A common experimental procedure to determine nucleosome positions involves the use of micrococcal nuclease ...
Ho-Ryun Chung +2 more
exaly +2 more sources
The Ies6 subunit is essential for INO80-mediated nucleosome organization [PDF]
Scientific ReportsATP-dependent nucleosome remodelers of the INO80 family regulate chromatin by sliding, spacing and positioning nucleosomes. The INO80 remodeler is organized into structural modules that regulate its remodeling activity.
Ashish Kumar Singh +1 more
doaj +2 more sources
Differential nucleosome organization in human interphase and metaphase chromosomes [PDF]
Molecular Systems BiologyDNA bendability plays a critical role in stabilizing nucleosome assembly, yet its contribution to nucleosome dynamics in vivo remains poorly understood.
Keren Li +10 more
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Predicting human nucleosome occupancy from primary sequence. [PDF]
PLoS Computational Biology, 2008 Nucleosomes are the fundamental repeating unit of chromatin and comprise the structural building blocks of the living eukaryotic genome. Micrococcal nuclease (MNase) has long been used to delineate nucleosomal organization.
Shobhit Gupta +5 more
doaj +1 more source
Structural Transition of the Nucleosome during Transcription Elongation
Cells, 2023 In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during ...
Tomoya Kujirai +3 more
doaj +1 more source
H3.3-H4 tetramer splitting events feature cell-type specific enhancers. [PDF]
PLoS Genetics, 2013 Previously, we reported that little canonical (H3.1-H4)(2) tetramers split to form "hybrid" tetramers consisted of old and new H3.1-H(4) dimers, but approximately 10% of (H3.3-H4)2 tetramers split during each cell cycle.
Chang Huang +7 more
doaj +1 more source
NucleoMap: A computational tool for identifying nucleosomes in ultra-high resolution contact maps.
PLoS Computational Biology, 2022 Although poorly positioned nucleosomes are ubiquitous in the eukaryotic genome, they are difficult to identify with existing nucleosome identification methods.
Yuanhao Huang, Bingjiang Wang, Jie Liu
doaj +1 more source
Nucleosome Organization in Human Embryonic Stem Cells. [PDF]
PLoS ONE, 2015 The fundamental repeating unit of eukaryotic chromatin is the nucleosome. Besides being involved in packaging DNA, nucleosome organization plays an important role in transcriptional regulation and cellular identity.
Puya G Yazdi +7 more
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A systematic analysis of nucleosome core particle and nucleosome-nucleosome stacking structure [PDF]
Scientific Reports, 2018 AbstractChromatin condensation is driven by the energetically favourable interaction between nucleosome core particles (NCPs). The close NCP-NCP contact, stacking, is a primary structural element of all condensed states of chromatin in vitro and in vivo.
Korolev, Nikolay +2 more
openaire +3 more sources
Genome Biology, 2021 We develop a novel computational method, NucHMM, to identify functional nucleosome states associated with cell type-specific combinatorial histone marks and nucleosome organization features such as phasing, spacing and positioning. We test it on publicly
Kun Fang +3 more
doaj +1 more source