Results 21 to 30 of about 75,018 (265)
Science Advances, 2015 Reestablishment of the nucleosome landscape behind the replication fork is fundamental for epigenetic memory during development.
Ramachandran, Srinivas, Henikoff, Steven
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BMC Evolutionary Biology, 2011 Background Divergence of transcription factor binding sites is considered to be an important source of regulatory evolution. The associations between transcription factor binding sites and phenotypic diversity have been investigated in many model ...
Chu Wen-Yi +4 more
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High nucleosome occupancy is encoded at human regulatory sequences. [PDF]
PLoS ONE, 2010 Active eukaryotic regulatory sites are characterized by open chromatin, and yeast promoters and transcription factor binding sites (TFBSs) typically have low intrinsic nucleosome occupancy. Here, we show that in contrast to yeast, DNA at human promoters,
Desiree Tillo +9 more
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Conservation of Nucleosome Positions in Duplicated and Orthologous Gene Pairs
The Scientific World Journal, 2012 Although nucleosome positions tend to be conserved in gene promoters, whether they are conserved in duplicated and orthologous genes is unknown. In order to elucidate how nucleosome positions are conserved between duplicated and orthologous gene pairs, I
Hiromi Nishida
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Manipulating chromatin architecture in C. elegans
Epigenetics & Chromatin, 2022 Background Nucleosome-mediated chromatin compaction has a direct effect on the accessibility of trans-acting activators and repressors to DNA targets and serves as a primary regulatory agent of genetic expression. Understanding the nature and dynamics of
John L. Carter +3 more
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Proceedings of the National Academy of Sciences, 1997 Archaea contain histones that have primary sequences in common with eukaryal nucleosome core histones and a three-dimensional structure that is essentially only the histone fold. Here we report the results of experiments that document that archaeal histones compact DNA in vivo
S L, Pereira +3 more
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Genome-scale identification of nucleosome organization by using 1000 porcine oocytes at different developmental stages. [PDF]
PLoS ONE, 2017 The nucleosome is the basic structural unit of chromosomes, and its occupancy and distribution in promoters are crucial for the regulation of gene expression.
Chenyu Tao +5 more
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Crystal structures of heterotypic nucleosomes containing histones H2A.Z and H2A [PDF]
Open Biology, 2016 H2A.Z is incorporated into nucleosomes located around transcription start sites and functions as an epigenetic regulator for the transcription of certain genes.
Naoki Horikoshi +3 more
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Ion counting demonstrates a high electrostatic field generated by the nucleosome
eLife, 2019 In eukaryotes, a first step towards the nuclear DNA compaction process is the formation of a nucleosome, which is comprised of negatively charged DNA wrapped around a positively charged histone protein octamer.
Magdalena Gebala +3 more
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Thermodynamic modeling of genome-wide nucleosome depleted regions in yeast.
PLoS Computational Biology, 2021 Nucleosome positioning in the genome is essential for the regulation of many nuclear processes. We currently have limited capability to predict nucleosome positioning in vivo, especially the locations and sizes of nucleosome depleted regions (NDRs). Here,
Hungyo Kharerin, Lu Bai
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