Results 21 to 30 of about 148,408 (312)
Nucleosome Organization in Human Embryonic Stem Cells. [PDF]
PLoS ONE, 2015 The fundamental repeating unit of eukaryotic chromatin is the nucleosome. Besides being involved in packaging DNA, nucleosome organization plays an important role in transcriptional regulation and cellular identity.
Puya G Yazdi +7 more
doaj +1 more source
The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. [PDF]
, 2009 Evenly spaced nucleosomes directly correlate with condensed chromatin and gene silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in vitro and is required for silencing in vivo.
Acevedo, Ashley +8 more
core +5 more sources
Physical Review Letters, 2008 We present a statistical-mechanical model for the positioning of nucleosomes along genomic DNA molecules as a function of the strength of the binding potential and the chemical potential of the nucleosomes. We show that a significant section of the DNA is composed of two-level nucleosome switching regions where the nucleosome distribution undergoes a ...
David J, Schwab +3 more
openaire +2 more sources
Science Advances, 2015 Reestablishment of the nucleosome landscape behind the replication fork is fundamental for epigenetic memory during development.
Ramachandran, Srinivas, Henikoff, Steven
openaire +2 more sources
The effect of micrococcal nuclease digestion on nucleosome positioning data. [PDF]
PLoS ONE, 2010 Eukaryotic genomes are packed into chromatin, whose basic repeating unit is the nucleosome. Nucleosome positioning is a widely researched area. A common experimental procedure to determine nucleosome positions involves the use of micrococcal nuclease ...
Ho-Ryun Chung +7 more
doaj +1 more source
Inter-nucleosomal potentials from nucleosomal positioning data
The European Physical Journal E, 2022 AbstractNo systematic method exists to derive inter-nucleosomal potentials between nucleosomes along a chromosome consistently across a given genome. Such potentials can yield information on nucleosomal ordering, thermal as well as mechanical properties of chromosomes.
Kunhe Li +3 more
openaire +2 more sources
TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner [PDF]
, 2012 Mammalian telomeres stabilize chromosome ends as a result of their assembly into a peculiar form of chromatin comprising a complex of non-histone proteins named shelterin.
Bauwens, Serge +10 more
core +13 more sources
Genome Biology, 2021 We develop a novel computational method, NucHMM, to identify functional nucleosome states associated with cell type-specific combinatorial histone marks and nucleosome organization features such as phasing, spacing and positioning. We test it on publicly
Kun Fang +3 more
doaj +1 more source
Biochemical characterization of the placeholder nucleosome for DNA hypomethylation maintenance
Biochemistry and Biophysics Reports, 2019 DNA methylation functions as a prominent epigenetic mark, and its patterns are transmitted to the genomes of offspring. The nucleosome containing the histone H2A.Z variant and histone H3K4 mono-methylation acts as a “placeholder” nucleosome for DNA ...
Rina Hirano +3 more
doaj +1 more source
DNA-encoded nucleosome occupancy is associated with transcription levels in the human malaria parasite Plasmodium falciparum. [PDF]
, 2014 BackgroundIn eukaryotic organisms, packaging of DNA into nucleosomes controls gene expression by regulating access of the promoter to transcription factors.
Bunnik, Evelien M +6 more
core +3 more sources