Results 91 to 100 of about 2,769,148 (383)

Chemistry of Abiotic Nucleotide Synthesis.

Chemical Reviews, 2020
The chemistry of abiotic nucleotide synthesis of RNA and DNA in the context of their prebiotic origins on early earth is a continuing challenge. How did (or how can) the nucleotides form and assemble from the small molecule inventories and under ...
Mahipal Yadav, Ravi Kumar, R. Krishnamurthy   +2 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The international nucleotide sequence database collaboration

Nucleic Acids Res., 2020
The International Nucleotide Sequence Database Collaboration (INSDC; http://www.insdc.org/) has been the core infrastructure for collecting and providing nucleotide sequence data and metadata for >30 years.
Masanori Arita, I. Karsch-Mizrachi, G. Cochrane   +2 more
semanticscholar   +1 more source

Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype [PDF]

, 2009
Nucleotide excision repair (NER) is responsible for repairing bulky helix-distorting DNA lesions and is essential for the maintenance of genomic integrity.
Alison Spiers, Ann K. Daly, Brian Burtle, Elizabeth A. Williams, Fiona Caple, Gaivão, John C. Mathers, John E. Hesketh, John Tyson, Qiao, Tomasetti, Wei   +11 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

IL-28B single nucleotide polymorphism as a predictor of hepatocellular carcinoma after treatment of chronic hepatitis C patients with direct acting antivirals [PDF]

, 2021
Nancy Abdel Fattah Ahmed, Ahmed Ali, Rizk Ahmed EL Baz, Islam Abd El-Hamid El-Zayyadi   +3 more
openalex   +1 more source

The nucleotide sequence of a human immnnoglobulin C-gamma-1 gene [PDF]

, 1982
We report the nucleotide sequence of a gene encoding the constant region of a human immnnoglobulin γ1 heavy chain (Cγ1). A comparison of this sequence with those of the Cγ2 and Cγ4 genes reveals that these three human Cγ genes share considerable homology
Berson, Bennett J., Ellison, Jay W., Hood, Leroy E.   +2 more
core  

Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes. [PDF]

, 2019
BackgroundGeneral translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states.
A Battle, A Dana, A Kozomara, A Radhakrishnan, A Reyes, AG Hinnebusch, AG Hinnebusch, AO Subtelny, AV Pisarev, CDS Duncan, CJ Shoemaker, CL Simms, D Fell, D Ray, D Weinberg, DH Mathews, DR Cavener, DR Groebe, EM Novoa, F Sinturel, GL Chew, Guo-Liang Chew, GW Li, H Firczuk, H Gingold, H Gingold, H Guo, H Kacser, J Sponer, JD Blair, Jingyi Jessica Li, JJ Li, JJ Li, JJ Li, JT Cuperus, KA Cottrell, LD Fernades, M dos Reis, M Gonzalez-Porta, M Kozak, M Lynch, Mark Douglas Biggin, Mary K. Thompson, MF Princiotta, MF Rojas-Duran, MJ Liu, MW Jones-Rhoades, ND Sen, P Janich, P Shah, PN Borer, PY Hsu, R Lorenz, R Tunney, R Zhang, S Dvir, S Nakagawa, SA Lima, SJ Marygold, T Ben-Yehezkel, T Tuller, T Tuller, T von der Haar, T Xia, TG Johnstone, V Castelo-Szekely, V Presnyak, WL Noderer, Y Seol, Y Zarai, YV Svitkin, Z Bloom-Ackermann   +71 more
core   +3 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Dynamic cluster-scaling in DNA

, 2010
It is shown that the nucleotide sequences in DNA molecules have cluster-scaling properties (discovered for the first time in turbulent processes: Sreenivasan and Bershadskii, 2006, J. Stat. Phys., 125, 1141-1153.).
A. Bershadskii, Ambjornsson, Bershadskii, Blow, Campa, Conti, Cule, Dauxois, Hennig, Hyrien, Jeon, Joyeux, Jun, Krueger, Li, Mesner, Peyrard, Podobnik, Rhind, Saenger, Shechter, Sponer, Sreenivasan, Stanley, Voss, Yang   +25 more
core   +1 more source