Results 121 to 130 of about 1,684,114 (372)
Model for processive nucleotide and repeat additions by the telomerase [PDF]
arXiv, 2007 A model is presented to describe the nucleotide and repeat addition processivity by the telomerase. In the model, the processive nucleotide addition is implemented on the basis of two requirements: One is that stem IV loop stimulates the chemical reaction of nucleotide incorporation, and the other one is the existence of an ssRNA-binding site adjacent ...
arxiv
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Aqueous microwaves assisted cross-coupling reactions applied to unprotected nucleosides.
Frontiers in Chemistry, 2015 Nucleoside analogues have attracted much attention due to their potential biological activities. Amongst all synthetic nucleosides, C5-modified pyrimidines and C7- or C8-modified purines have mostly been prepared using palladium cross-coupling reactions ...
CHRISTOPHE eLEN, Gwénaelle eHervé
doaj +1 more source
EMBO Journal, 1986 The complete nucleotide sequence (155 844 bp) of tobacco (Nicotiana tabacum var. Bright Yellow 4) chloroplast DNA has been determined. It contains two copies of an identical 25 339 bp inverted repeat, which are separated by a 86 684 bp and a 18 482 bp ...
K. Shinozaki +22 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
DISTRIBUTION OF ENZYMES CLEAVING PYRIDINE NUCLEOTIDES IN ANIMAL TISSUES [PDF]
, 1957 K. Bruce Jacobson, Nathan O. Kaplan
openalex +1 more source
Determinative degree and nucleotide sequence analysis by trianders [PDF]
arXiv, 2003 A new version of DNA walks, where nucleotides are regarded unequal in their contribution to a walk is introduced, which allows us to study thoroughly the "fine structure" of nucleotide sequences. The approach is based on the assumption that nucleotides have an inner abstract characteristics, the determinative degree, which reflects phenomenological ...
arxiv
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Silica Monolithic Capillary Columns for Hilic Separations
Hungarian Journal of Industry and Chemistry, 2018 The monolithic capillary columns (0.1 mm x 150 mm) prepared by the acidic hydrolysis of tetramethoxysilane (TMOS) in the presence of polyethylene glycol (PEG) and urea were modified by zwitterionic stationary phases and evaluated under HILIC separation ...
Moravcová Dana, Planeta Josef
doaj +1 more source
Identification and Measurement of Neighbor Dependent Nucleotide Substitution Processes [PDF]
arXiv, 2005 The presence of neighbor dependencies generated a specific pattern of dinucleotide frequencies in all organisms. Especially, the CpG-methylation-deamination process is the predominant substitution process in vertebrates and needs to be incorporated into a more realistic model for nucleotide substitutions.
arxiv